Sentences with phrase «specific cells involved»

The release of inflammatory chemicals called «cytokines» (proteins secreted by specific cells involved in immunity and in inflammation) leads to biochemical reactions involving neurotransmitters.

Not exact matches

Those two companies, along with their larger competitor Novartis (nvs), are developing experimental chimeric antigen receptor T - cell (CAR - T) technology platforms, which are highly personalized treatments that involve extracting patients» immune cells, re-engineering them to target their specific cancers, and then pumping these sniper - cells back into the body.

Joseph Berry, senior research scientist at the National Renewable Energy Laboratory, who studies solar cells but was not involved in the research, said the research project is interesting because the device scales well and targets a specific part of the solar spectrum.

A specific genetic marker influences response to therapy in the early stages of RA; a link thought to be due to the gene activating a cell - signalling protein involved in the inflammatory disease process.

The findings highlight specific sets of genes and the brain cells they affect as being involved in regulating anxiety.

The first key experiment involved removing a specific subset of activated T - cells from mouse models.

In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.

«Our study also indicates that the path towards iPS cells involves the use of specific control switches on DNA called enhancers,» adds Dr Constantinos Chronis from UCLA.

«Use of induced pluripotent stem cell (iPSC) technology» — which involves taking skin cells from patients and reprogramming them into embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.

Glk1 is a transcription factor, meaning it binds to specific regions of DNA and activates genes involved in cell death and other plant immune responses.

Photodynamic therapy (PDT), involves the use of chemicals called photosensitizers that are activated by exposure to specific wavelengths of light to release reactive molecules that can damage nearby cells.

All of the diseases, which cause the death of brain cells involved in controlling body movements, have recently been traced to specific genes.

In addition, the two genes are turned on in areas that are part of the cortico - striatal - thalamo - cortical circuit, a loop of brain cells connecting the cortex to specific regions involved in processing emotions and movement.

The method, which involves inserting genetic material that makes the cells» development run backwards, opens the door to stem cells specific to patients, which could be used to repair damaged organs or fight diseases such as Parkinson's and diabetes — crucially, all without the need to destroy human embryos.

The researchers found that Zika targeted two specific cell types in mice: spermatogonia, which make sperm, and Sertoli cells, which are involved in helping sperm develop and sheltering them from the blood and immune system, building what's called the blood - testis barrier.

Doing the screen involves using short pieces of RNA, called small hairpin RNAs, which are inserted into the cell and are able to halt messages from specific genes, keeping the genes from making proteins.

For example, the division plane at which cell division takes place is marked by correct patterning of specific proteins, and should be robust against alterations in the relative concentrations of the proteins involved.

Previous versions of X-Cab, which involves driving a virtual taxi through a cybercity, have confirmed that humans have place cells, too, as well as view cells that respond to specific landmarks and goal cells that respond to the driver's ultimate destination.

The publication in ACS Chemical Biology marks the first time that redox activity, a very fast regulatory network involved in all major aspects of a cell's operation, has been observed in specific proteins within living cells.

This involves using a virus to add a gene to immune cells to make them target specific cancers.

By culturing human stem cells in this manner and treating them with specific signaling molecules, the investigators were able to guide cells through key processes involved in the development of the human inner ear.

This involves using a virus to add a gene to immune cells that make them target specific cancers.

The signal, which has been known for a long time, involves an enzyme present in every cell of the body, called PKR, which remains silent unless it is activated by a specific RNA structure thought to occur only in RNA made by viruses.

He said the genome study detected changes in one specific gene involved in the body's temperature regulation that may be related to metabolic differences in whale cells.

Their results turned up an unexpected commonality: Early on in each of the diseases, genes involved in the same specific pathway of cell death appeared to be activated.

«RNAi therapies are a unique approach to cancer treatment as they have the potential to «turn off» the genes» coding for proteins involved in cancer cell division,» said Ramesh K. Ramanathan, M.D., medical director of the Virginia G. Piper Cancer Center Clinical Trials Program at Scottsdale Healthcare and deputy director of the Clinical Translational Research Division of the Translational Genomics Research Institute (TGen) in Phoenix, Ariz. «Using a lipid nanoparticle, the RNAi drug can be delivered to a cancer cell to block the expression of specific proteins involved in tumor growth.»

TKM - 080301 targets a specific gene called polo - like kinase 1 (PLK1), which codes for a protein involved in tumor cell growth.

Brain cells in a specific region of the brain secrete dopamine, a chemical involved in addiction, movement and motivation.

These studies use a combination of cell biology, molecular biology and electrophysiology in cultured sensory - motor neurons from the marine invertebrate Aplysia californica, and cultured neurons from mouse hippocampus, and involve investigation of the function of specific molecules in neurons.

John O'Keefe, along with John Dostrovsky, discovered in 1971 that the hippocampus contains special nerve cells that are involved in determining an animal's specific location, which they called place cells.

Current understanding of Bcl - xL's structure describes a protein with three regions — a core that interacts with proteins involved in cell death, a flexible region lacking defined structure (IDR) with an unknown function, and a membrane - anchoring region that attaches the protein to specific sites within the cell.

Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell surface proteins that function in the interactions of immune cells with other cells, including antigen - specific recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.

Brain cells in a specific region of the brain secrete dopamine, a chemical involved in addiction, movement...

A specific protein, called GPNMB, is important for keeping cells healthy and is involved in generating and storing pigments.

Based on our recent development allowing the efficient and robust conversion of human pluripotent stem cells into affected spinal motor neurons and non - affected cranial motor neurons, our objective is to deepen the mechanisms involved in the specific degeneration of spinal motor neurons in SMA as well as the mis communication of these neurons with their muscular target.

The complex then migrates into the cell nucleus, and activates the transcription of specific target genes which are involved in physiological and pathological bone formation (Chen, Deng & Li, 2012; Katagiri & Tsukamoto, 2013; Miyazawa et al., 2002).

Interaction of human mesenchymal stem cells with cells involved in alloantigen - specific immune response favors the differentiation of CD4 + T - cell subsets expressing a regulatory / suppressive phenotype.

CAR - T immunotherapy involves genetically outfitting a patient's immune cells with a new artificial gene, a chimeric antigen receptor (CAR), which allows the cells to recognize and attack specific cancer cells.

Specific activities include optimizing the conduct and oversight of gene transfer research, updating and interpreting biosafety policies under the NIH Guidelines Involving Research with Recombinant and Synthetic Nucleic Acids, providing critical input on governmental policies regarding dual use research, the NIH Stem Cell Registry.

Recently, we reported the discovery of a specific subclass of macrophages involved in the recognition of senescent cells.

This project — in collaboration with Texas A & M University — involves screening small molecules for specific effects on the yeast cell cycle that correlate with longevity.

Our current work defines one more component of a specific branch of innate immunity responsible for the recognition and clearance of senescent cells and presumably involved in keeping us young.

To determine whether huntingtin is involved in trafficking a specific subset of proteins, we measured changes in global transcription levels in embryonic stem cells and neurons lacking huntingtin.

Parkinson's, Alzheimer's, and autoimmune diseases involve damage to specific cell types.

Because magnetic separation technology is gentle and does not involve harsh chemicals or conditions, MagSi - Direct opens up new avenues for isolating, purifying or characterising cells that interact with specific ligands.

In a discovery screen profiling 102 cell lines against 8,400 compounds, PRISM led the researchers to a specific novel compound, BRD - 7880; the specific action against cell lines in the panel rapidly led them to discover that this compound worked by inhibiting aurora kinase B, an enzyme involved in cell division that is abnormally regulated in several cancers.

To define the phenotype and function of specific cellular populations involved in the cross-talk between cancer and immune cells we make use of both flow - cytometry and mass - cytometry.

Here, we investigate the recent evolution of sex - specific wing size differences between two species that involve changes to cell size and number regulation.

For example, new combinations of domains in death-fold domain proteins and laminins possibly allow for the modification of protein interactions and pathways involved in programmed cell death and cell adhesion, respectively (Supplementary Note 9.3), and the co-option of sponge -, eumetazoan - or bilaterian - specific architectures into novel functions.

Stewart discovered that the histone modifications that poise embryonic stem cell - specific genes for activation are also found on the histones near genes involved in regeneration, putting them into a ready - to - go state.