Sentences with phrase «specific cellular protein»

Using this system, Spence and Chandran showed that a specific cellular protein, called NPC1, must interact directly with the Ebola glycoprotein for fusion to occur.

Not exact matches

Frey's team did not train their system to predict diseases, but instead to take measurements of contents within a cell (metrics such as the concentration of a specific protein) and draw conclusions about the cellular system as a whole.

Once constructed, those amino acid strings spontaneously fold up into proteins, each with a specific 3D shape that governs its cellular function.

During the early years of my PhD studies, I was very fascinated by the exciting discoveries in the field of signal transduction, in particular how receptor tyrosine kinases are activated to transmit their signals and how protein complexes are formed through defined protein folds (domains) interacting with specific cellular targets.

Proteins are responsible for the vast majority of the cellular functions that shape life, but like guests at a crowded dinner party, they interact transiently and in complex networks, making it difficult to determine which specific interactions are most important.

Activation of a gene induces a cell to make an RNA copy of its code, edit unneeded segments out of that message, and splice together a final version of the message that provides cellular factories (ribosomes) with a template to make one specific protein.

CUET proteins also associate with specific cellular structures that target the whole complex to the cellular waste disposal and recycling station, the lysosome.

Direct measurement of such compound target engagement in a cellular or tissue context has traditionally been difficult to establish without the development of specific tool compounds and / or protein modifications with reporter functionalities.

Cas9 uses short RNA molecules, known as guide RNAs, to target the protein to a specific sequence within cellular DNA.

Finally, in a collaboration with Frank Jülicher's group at the Max Planck Institute for the Physics of Complex Systems, we are using these data to develop physical models that will help us understand how local cellular adhesive, elastic and contractile properties are influenced by PCP proteins and other molecules, and how they combine to produce specific packing geometries at a global level.

The SMDC has allowed Gladstone scientists to design molecules to modulate the functions of proteins or specific cellular phenotypes and, most significantly, screen for drugs that could be used as therapies for disease.

Our strong expertise allows us study lipid - protein interaction based phenomena at different scales, from the organ and cellular systems down to minimal synthetic systems in which we can control the proteins as well as the lipid, for instance to monitor the allosteric effects of specific lipids on fundamental receptors such as the EGF receptor (Coskun et al (2011) PNAS) and the insulin receptor.

A recent study14 in Frontiers in Molecular Neuroscience notes that iron - restricted diets «affect brain ferritin levels, dopamine metabolism and cellular prion proteins in a region - specific manner» — effects that highlight the importance of adequate iron for general brain health and for the prevention of neurological diseases.

It outlines a clear chain of cellular events, from the binding of DNA, through a specific signaling pathway, to the reduction of proteins known to trigger inflammation.»

They do not kill cancerous or viral cells, but regulate the action of specific genes that control the production of cellular proteins that affect cell growth.

At the cellular level, there are a great many proteins, each with a specific job to do.

Well, it could be that the supplements are full of amino acids and phytonutrients that are amazing for the overall health of the body (which naturally improves the health of the skin) or it could be that the specific amino acids that the collagen protein are utilized to produce more collagen — again, the jury is still out at the cellular level.