Sentences with phrase «specific changes in the expression»

The study shows that even small, tissue - specific changes in the expression of genes can have noticeable morphological effects.

Antagonists of growth hormone releasing hormone (GHRH) given before whole body radiation lead to modulation of radiation response and organ - specific changes in the expression of angiogenesis.

Not exact matches

In our leadership work we show our leaders how to transmit a precise type of leadership impact to meet different business outcomes by using various specific postures and facial expressions that prime your behaviors to achieve the particular business outcome, as well as signal to others how your behaviors will change outcomes.

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

«Many thyroid diseases will be impacted by changing the expression levels of the thyroid - specific transcription factor, so we want to investigate FOXE1 more carefully in future work.»

Since our collection of cell lines is completely genetically annotated — which means that mutations and expression changes in each line's genes have been documented — we should be able to identify in advance patients who will benefit from specific combinations.

We identified species - specific gene expression patterns indicating that changes in protein and gene expression have been particularly pronounced in the human brain.

Using this «Ribotag» approach tissue - specific changes under DR have been measured in muscle, fat, gut, heart, neurons, germline and malpighian tubules, showing a highly tissue specific response upon DR.. We are developing mechanistic models of gene expression regulation and conducting comprehensive bioinformatics analyses on UTRs, promoters and the coding sequences of various elements of differentially regulated genes.

Long - lasting changes in brain connectivity require new gene expression, and Dr. Martin has discovered a role for specific signaling molecules that travel from stimulated synapses to the nucleus to change the transcription of DNA to RNA.

Because PMI dependent expression changes are largely tissue - specific, they could confound tissue differential gene expression since the observed effects could be caused by differential response to PMI rather than by differences in tissue biology.

Dr. Pollard's group aims to pinpoint specific DNA alterations in these sequences that are responsible for changes in gene expression.

We find that many genes change expression over relatively short PMIs in a tissue - specific manner, but this potentially confounding effect in a biological analysis can be minimized by taking into account appropriate covariates.

Hence, if endocrine disruptors have the potential to change metabolism in humans via alterations in PPAR expression, sex - specific differences will have a causal explanation.

«When we looked at gene expression, we found fairly small changes in 65 million years of the macaque, orangutan, and chimpanzee evolution,» said study author Yoav Gilad, PhD, assistant professor of human genetics at the University of Chicago, «followed by rapid change, along the five million years of the human lineage, that was concentrated on these specific groups of genes.

To ensure the detection of brain - specific changes in dilp5 expression, RNA extracted from the brain was used for RT - qPCR.

Further, it would suggest that sex - specific morphology can evolve by spatially regulated changes in expression within the sex - determining pathway without disrupting other sex - determination functions.

Our observation that the V+S + fraction preferentially contributes to the VE when mixed with more ICM - like cells indicates that low - level lineage - specific changes in gene expression have functional consequences.

Makarevitch I, Harris C * (2010) Aneuploidy causes tissue - specific qualitative changes in global gene expression patterns in maize.

These include: a) Global Clusters that consist of a small, tight subset of genes that are co-expressed under the entire spectrum of experimental conditions; b) Time Series of gene expression profiles during successive days of standard ES cell differentiation; c) Specific Gene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES databaseexpression profiles during successive days of standard ES cell differentiation; c) Specific Gene Classes based on hierarchical clustering of transcriptional factors and ESTs; d) Expression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES databaseExpression Waves of genes with characteristic expression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES databaseexpression profiles during ES cell differentiation, juxtaposed to waves of genes that behave in the exact opposite way; e) Pathway Animations that illustrate dynamic changes in the components of individual KEGG signaling and metabolic pathways viewed in time - related manner; and, f) Search Engines to display the expression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES databaseexpression pattern of any transcript, or groups of transcripts, during the course of ES cell differentiation, or to query the association of candidate genes with various FunGenES database clusters.

In cells arrested overnight by a specific arrest signal, gene expression changes are largely signal - specific with a small amount of overlap.

Several recently published studies have evaluated various methods to assess pain in cats and have identified specific physiological and behavioral changes including a cat's facial expression as a means to assess pain in cats.2, 3,4

If anyone wants to tell me that the expression «climate change» now has a consensual usage beyond its common meaning, I'd ask why people who are supposed to rely on specificity have never shown any interest in finding specific terminology for the very phenomenon which is at the centre of all their concerns.

Conclusion: Complementing CBT interventions for GD with a specific therapy approach like a serious video game might be helpful in addressing certain underlying factors which are usually difficult to change, including impulsivity and anger expression.