This results in potent and highly
specific drug candidates.
Not exact matches
Either way, our findings suggest that CD11b is a key
candidate for
specific drug development strategies in Guillain - Barré syndrome.»
Instead of systematically testing the effects of known compounds — the pharmaceutical industry's basic model for more than a century — scientists can now investigate backward, combing through genomic data to find links between
specific genotypes and diseases and then screening
drug data to identify therapeutic
candidates.
The new process, called Extensive Combinatorial Refinement (ExCoR), could help improve the development of
drug candidates that depend to a great degree on detailed structural analysis to determine how they work against
specific disease targets.
Those signals can also be useful indicators for screening, such as scanning blood or urine for
specific compounds or scanning proteins to detect strong or weak binding with a
drug candidate.
Quantitative proteomics can also be applied to identify major
candidates of proteins targets and mechanism of action by specifically designed experiments using multiple
drug / compounds in addition to that / those of interest and probing
drug / compound -
specific proteome responses to a treatment.
• Personalized
drug safety can be addressed with patient - derived cells in Organ - Chips, enabling a patient -
specific approach for assessing the safety and efficacy of new
candidates while taking into account patient variability and the unique biology of individual patients.
Excitingly, because stem cells can produce such large numbers of neurons, we can even test for and identify new
drug candidates using patient
specific neurons.