Sentences with phrase «specific effector»

Such a dramatic accumulation of virus - specific effector CTL might impair the ability to respond to heterologous infection and may underlie the negative influence of CMV seropositivity on survival in the very elderly.

Here we show that HO - 1 inducers inhibit antigen - specific effector T cells when injected intradermally together with the T cell cognate antigens in mice.

Relative importance of rotavirus - specific effector and memory B cell responses in protection against challenge.

Therefore identifying the essential, tissue - specific effectors of Hh has the potential to lead to the identification of more specific therapeutic targets.

Not exact matches

To be more specific, the cybernetic model claims that the machinery of any self - correcting, goal - directed organization is made up of receivers of information, a control center, and effectors of action.

It includes BPA's robotic platform provided with dedicated handling parts to match your specific application, including our patented SmartTrak system for high speed bag pre-collation and end - effector.

Site - specific administration of chemokines (CXCL9 - 10) restored homing signals that were diminished in septic hosts to permit recruitment of effector cells to the skin.

In reaction to infection or inflammation, immune system cells known as effector T cells (Teffs) undergo rapid changes - arming themselves and diversifying into groups that target specific diseased cells.

Their results demonstrate that specific rhoptry and dense granule effector proteins that T. gondii secretes before and after host cell invasion, respectively, control the development of an effective host antitumor response, and increase the survival of mice with ovarian tumors.

TAL effectors are produced in nature by certain bacteria that infect plants and are able to bind to specific sequences in the plant DNA, thereby neutralizing the plant's defense mechanisms.

Therefore, in both mice and non-human primates, HO - 1 inducers delivered locally inhibited effector T - cells in an antigen - specific manner, paving the way for repositioning these drugs for the treatment of immune - mediated diseases.

Although similar numbers of total splenic gp33 - LCMV — specific T cells were observed between genotypes (Fig. 5B), the distribution of gp33 - LCMV — specific CD8 + T cell effector and memory subsets were altered, such that there was a significantly lower percentage of short - term effector T cells and reciprocal changes in memory precursor cells among gp33 - specifc CD8 + T cells in WT relative to DKO mice (Fig. 5C), with a trend in changes in absolute cell numbers, consistent with temporal data from peripheral blood (Fig. 5A).

Six weeks postinfection, splenocytes were analyzed for gp33 - LCMV — specific total CD8 + T cells (B) or short - lived effector cells and memory precursor effector cells (C).

Consistent with prior reports on effector cells (35), we observed that, among CD8 + T cells specific for the dominant epitope of LCMV (GP33), the percentages of short - lived effector cells (KLRG1 + CD127 −) were increased, and the percentages of memory precursor cells (KLRG1 + CD127 +) were decreased in the peripheral blood of DGKζ − / −, Cbl - b − / −, and DKO mice relative to WT mice after acute infection (Fig. 5A).

Science magazine heralded these transcription activator - like effector nuclease proteins, known as TALENS, as a major scientific breakthrough in 2012, nicknaming them «genomic cruise missiles» for their ability to allow researchers to target specific locations with great efficiency.

Antibodies are key effector molecules in health and disease as they harbor the ability to recognize specific molecular structures and, consequently, elicit immune responses.

Identifying any Hymenoptera - specific immune pathways or effectors that may exist is also of key importance for understanding the biology of host - pathogen interactions that may be relevant for such challenges as colony collapse disorder [42]--[44].

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.

Furthermore, CMV - specific CTL have a highly polarized membrane phenotype that is typical of effector memory cells (CD28 -LRB--), CD57 (+), CCR7 -LRB--)-RRB-.

This demonstrates that aging is associated with a marked accumulation of CMV - specific CD8 T cells together with a decrease in immediate effector function.

To reverse the attenuating effects of potassium on T cell effector function, the team genetically engineered tumour - specific T cells to express additional molecular pumps that specifically remove surplus potassium from the cell.

We demonstrate a novel outcome of S1P - mediated regulation of lymphocyte trafficking, whereby deletion of Spns2, either globally or in a lymphatic endothelial - specific manner, creates a circulating lymphopenia and a higher percentage of effector T cells and natural killer (NK) cells present in the lung.

We have shown previously that a specific class of RLCK kinases (VIA) is potential ROP effectors.