Sentences with phrase «specific embryonic stem»

This approach to derive patient - specific Embryonic Stem cell - like cells (iPS cells) is going to open up research into the genetic causes of disease and the search for therapies not only for such diseases, but also for repairing tissues damaged in other ways.

If I recall correctly, his paper had been published in Science, and it had been fast - tracked in what seemed transparently to be part of a political effort to sell the public on human cloning to produce patient - specific embryonic stem cells.

British regulators have given a cautious green light to research that would use animal eggs to produce patient - specific embryonic stem (ES) cells.

Not exact matches

All stem cells are immature cells known for their ability to multiply indefinitely and give rise to progenitor cells that mature into specific cell types that populate the body's tissues during embryonic development.

«Use of induced pluripotent stem cell (iPSC) technology» — which involves taking skin cells from patients and reprogramming them into embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.

But in the presence of specific Wnt proteins, there appear to be more embryonic stem cells among the daughters.

Instead of mimicking the complex 3D organization of the developing pituitary gland, this approach relies on the precisely timed exposure of human pluripotent stem cells to a few specific cellular signals that are known to play an important role during embryonic development.

Replacement tissue that avoids rejection by a patient's immune system is a step closer to the clinic, as researchers have created human embryonic stem cells carrying the DNA of specific adults.

A new study in Nature Genetics identifies a specific population of pluripotent embryonic stem cells that can reprogram to totipotent - like cells in culture.

During embryonic development, organ - specific cell types are formed from pluripotent stem cells, which can differentiate into all cell types of the human body.

In 2006, Woo Suk Hwang had to retract two papers published in Science in which his team claimed it had used the technique employed in cloning Dolly the sheep to create human embryonic stem cells matched to specific people who had various diseases.

To tap embryonic stem cells» therapeutic potential, researchers must learn how to coax them to become a specific type of cell that can then be transplanted into the body.

Use of the immunofluorescent microscopy visualization technique reveals the presence of specific proteins in naive human embryonic stem cells.

When the researchers added a specific bone morphogenetic protein called BMP4, as well as another signaling molecule called retinoic acid, to human embryonic stem cells, they got a mixture of two types of sensory interneurons.

Expanding from their previous studies with mice, the researchers first established that under specific conditions, culturing human embryonic stem cells with fibroblast growth factor 2 (FGF2) leads to neural differentiation particular to the midbrain / hindbrain region — the location of the cerebellum — within three weeks, and the expression of markers for the cerebellar plate neuroepithelium — the part of the developing nervous system specific for the cerebellum — within five.

Human embryonic stem cells derived from affected embryos during a pre-implantation diagnostic (PGD), as well as the conversion of somatic cells, such as skin fibroblasts, into induced pluripotent stem cells by genetic manipulation, offer the unique opportunity to have access to a large spectrum of disease - specific cell models.

In this edition, we're going to take a look at a very interesting tool that can be used for creating (excuse the pun) specific, targeted DNA modifications in transgenic animals, embryonic stem cells, and / or tissue - specific cell types: Cre - lox recombination.

Pluripotent cells such as embryonic stem (ES) and induced pluripotent stem (iPS) cells are the starting point from which to generate organ specific cell types.

BRD7, a novel PBAF - specific SWI / SNF subunit, is required for target gene activation and repression in embryonic stem cells.

Reprogramming adult cells to function like embryonic stem cells is one way researchers hope to create patient - specific cell lines to regenerate tissue or to study specific diseases in the laboratory.

Smithies was awarded the Nobel Prize in 2007 alongside Mario Cappecchi and Martin Evans «for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells».

Disease - specific human pluripotent stem cells, from embryonic origin or derived from reprogramming somatic cells, offer the unique opportunity to have access to a large spectrum of disease - specific cell models.

Human embryonic stem cell - derived neurons establish region - specific, long - range projections in theadult brain

By: Sadhana Agarwal, Katherine L. Holton, Robert Lanza Differentiation of human embryonic stem cells (hESCs) to specific functional cell types can be achieved using methods that mimic in vivo embryonic developmental programs.

Embryonic stem cells (ESCs) represent a source for the large numbers of modified EPCs required to therapeutically inhibit tumorigenesis [3], although patient - specific induced pluripotent stem cells (iPSCs) represent a more attractive option.

They usually had to work with undifferentiated embryonic stem cells that were very hard to come by or tissue - specific adult stem cells that lacked needed flexibility.

The second method used somatic cell nuclear transfer (cloning techniques) to exchange all the mtDNA from the patient's cells with normal mtDNA from an egg donor in order to derive embryonic stem cells that are patient - specific with respect to nuclear DNA, but «rescued» with respect to mtDNA.

This two - volume reference integrates this exciting area of biology, combining the prerequisites for a general understanding of adult and embryonic stem cells, the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations, as well as a presentation by the world's experts of what is currently known about each specific organ system.

These cells, called induced pluripotent stem cells (iPSCs), are created by forcing adult cells to produce proteins specific to embryonic stem cell functions, causing the adult cells to look and act like ESCs.

Other groups are using human embryonic stem cells, and others are exploring RPE - specific stem cells that can be grown from the adult RPE, for example, from eyes donated to eye banks.

By activating a gene called Ras in cells bathed in a very specific culture medium, scientists were able to cause embryonic stem cells — which originate from the inner cell mass of the blastocyst — to become more like the trophoblastic stem cells that give rise to the placenta from the outer portion of the blastocyst.

To determine whether huntingtin is involved in trafficking a specific subset of proteins, we measured changes in global transcription levels in embryonic stem cells and neurons lacking huntingtin.

«Having a very efficient and practical way of generating patient - specific stem cells, which unlike human embryonic stem cells, wouldn't be rejected by the patient's immune system after transplantation brings us a step closer to the clinical application of stem cell therapy,» says Belmonte, PhD., a professor in the Gene Expression Laboratory and director of the Center of Regenerative Medicine in Barcelona, Spain.

Topics covered include embryonic stem cells, pluripotency, germline stem cells, tissue - specific stem cells, stem cell differentiation, epigenetics, stem cell genomics and systems biology, genome reprogramming, cancer stem cells, stem cell niches, stem - cell - based disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging of stem cells, therapeutic applications, regenerative medicine, clinical and translational insights, stem cell research policies, ethical issues, and technical or resource - based innovations.

While it has long been known that embryonic stem cells have the ability to develop into any kind of tissue - specific cells, the exact mechanism as to how this occurs has heretofore not been demonstrated.

Some researchers are using induced pluripotent stem (iPS) cells — tissue - specific cells (usually skin cells, but sometimes other tissue cells) that are reprogrammed in the lab to behave like embryonic stem cells — to grow rods and cones or RPE cells.

Both human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) can colonize the mouse embryo in a manner predicted from classical developmental fate mapping and faithfully recapitulate tissue - specific fate post-transplantation.

His laboratory recently demonstrated a novel use of a specific gene - targeting technique for human embryonic stem cells.

We also used it to study transition of mouse embryonic stem cells to a specific cell state of interest in Eckersley - Maslin et al Cell Reports 2016.

The new fund will offer researchers university - wide resources for both embryonic and tissue - specific stem cell research in the university's Medical School and Center for Stem Cell Biolstem cell research in the university's Medical School and Center for Stem Cell BiolStem Cell Biology.

Patient - specific stem cells may offer an alternative to embryonic stem cells that will skirt the need for immunosuppressive therapy as well as the social and political ramifications of embryonic stem cell research, but their utility extends far beyond such groundbreaking advances and will assist future clinical practice and patient care.

Neural stem cells are found in adult or fetal brain and spinal cord or derived from embryonic stem cells, which have the capacity to become any cell type in the body, or induced pluripotent stem (iPS) cells, tissue - specific cells that are reprogrammed in the lab to behave like embryonic stem cells.

Stewart discovered that the histone modifications that poise embryonic stem cell - specific genes for activation are also found on the histones near genes involved in regeneration, putting them into a ready - to - go state.

To overcome these hurdles, Bhatia and her team reprogrammed human skin cells into induced pluripotent stem cells (iPSCs)-- embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease.

* The role of the US in global efforts to address pollutants that are broadly dispersed across national borders, such as greenhouse gasses, persistent organic pollutants, ozone, etc...; * How they view a president's ability to influence national science policy in a way that will persist beyond their term (s), as would be necessary for example to address global climate change or enhancement of science education nationwide; * Their perspective on the relative roles that scientific knowledge, ethics, economics, and faith should play in resolving debates over embryonic stem cell research, evolution education, human population growth, etc... * What specific steps they would take to prevent the introduction of political or economic bias in the dissemination and use of scientific knowledge; * (and many more...)