Sentences with phrase «specific epigenetic modifications»
Not exact matches
«For example, we now know that RNA can be methylated just like DNA and in a highly specific way,» says Dr. Manel Esteller, «and even more recently we observed that these epigenetic modifications of RNA may be key in the regulation of «guardian» RNAs, also called non-coding RNAs.»
https://www.sciencedaily.com/
Schrock: I'm sure that's been tried, but one of the new things they found is this specific tie between the circadian rhythm in our bodies and drug addiction and they found that it is actually through an epigenetic modification of the circadian rhythm; so our circadian rhythms are reset by these drugs; we actually crave them at certain times of day and that is contributing to the necessity to, you know, relapse and go back on drugs or to get that craving, you know, at a certain point.
Epigenetic modifications label specific regions of the DNA to attract or keep away proteins that activate genes.
A Ludwig Cancer Research study published online September 14th in Nature reports a novel technique to map specific chemical (or «epigenetic») modifications made to the protein packaging of DNA using a small population of cells.
So what we think is that probably in many cells in this section, all cells, the chromatin is encountered in a specific state, and in order to render the cell is permissive to reprogramming, you have to overcome these certain epigenetic modifications that block, for example, the binding of Ascl1 to its target chains, or the binding of other transcription factors to its target chains, then this way interfere with the possibility of reprogramming.
Epigenetic modifications are partly inherited, but unlike the genome itself, are cell specific, plastic, and responsive to environmental influences.
The overall goal of the core is to provide support to investigators interested in characterizing the interactions of post-translational modifications of histones (epigenetic marks that define a chromatin state or Epigenome) or transcription factors at specific genomic loci or genome - wide (Cistrome).