Sentences with phrase «specific gene effect»

(It is estimated that any specific gene effect accounts for less than 1 % of the variance of complex traits [81].)

Not exact matches

In fact, specific genes are studied for their impact on the threshold effect of some teratogens.

«This confirms something we have long suspected, namely that the effects of sleep deprivation are not general in nature, but rather depend on the specific task and the genes of the person performing the task.»

Specific genes affect the risk of leprosy, says Amos, which may drown out the subtler effects of relatedness.

This vaccine would include a circular plasmid of DNA with the genes of specific proteins of the Zika virus inserted into it, and its effect will be similar to that of an inactivated vaccine — making the virus unable to copy itself.

Studies suggesting a link between the placebo effect and a set of specific genes & mdash

The study shows that even small, tissue - specific changes in the expression of genes can have noticeable morphological effects.

This time, it's a specific mutation in the EPSPS gene that guards the plant against the effects of glyphosate.

But if you knew that the effect of a drug had a lot to do with whether you inherited specific genes from your mother or father, then you could design an experiment that would include parents.

Alonso and Stepanova say that although the results are specific to ethylene, the findings provide a blueprint for examining other plant hormones and their effects on genes.

These regions can be clumped into larger areas of the genome called quantitative trait loci, which are known to contain genes that produce a specific physical effect, such as shaggy hair.

Using advanced molecular screening tools, our scientists identify the specific gene modifications that produce the desired effects in laboratory plants.

Because PMI dependent expression changes are largely tissue - specific, they could confound tissue differential gene expression since the observed effects could be caused by differential response to PMI rather than by differences in tissue biology.

We find that many genes change expression over relatively short PMIs in a tissue - specific manner, but this potentially confounding effect in a biological analysis can be minimized by taking into account appropriate covariates.

Sex differences describe biology - linked differences between women and men, which are caused by differences in sex chromosomes, sex - specific gene expression of autosomes, sex hormones, and their effects on organ systems (Figure 1)(1, 3).

The researchers hoped to create a cellular model to parse the effects of specific gene mutations, according to a press release, but in the process they discovered that skin cells from FOP patients were much more readily converted into iPSCs than cells from healthy individuals.

It's a complicated picture, to be sure, but it suggests some specific areas in which noncoding variants are exerting a cis - regulatory effect on the LPA gene.

Lead author Corina Greven says: «The specific genes involved in academic self - confidence remain to be identified, but we expect them to be many genes of small effect size, and their effects will be probabilistic rather than deterministic.

Ideally, the researchers found that the best targets were genes or proteins primarily expressed in one specific tissue, so the drug treats the disease at its core, without interfering with other, healthy tissues or organs, and thus causes fewer side - effects.

Rather than the expected virulence factor, the newly discovered E. coli - specific genes helped protect the bacteria from the toxic effect of metal ions the body uses to fight infection.

Our tool thus allows users with biological knowledge to study the possible effects that their set of SNPs might have on these genes and predict their cell - specific expression levels relative to the population.

We have introduced a gene into the mosquitos so that their cells do not function as they should, and this effect is specific to the mosquito (also known as a «self - limiting» gene because it makes mosquito reproduction a dead end — the offspring do not survive to adulthood).

«Those DNA sequences were put into the mutant; this allows you to test the effect of the gene if it is only switched on in a specific layer.»

In addition to effects on translation and DNA replication gene expression, high - replicate RNA - seq in morphologically normal individuals demonstrates a stable regulatory response of epigenetic modifiers and the specific de-repression of a group of zinc finger genes residing in constitutive heterochromatin.

It is well known that purebred dog breeds are associated with differing susceptibility to specific malignancies, suggesting that selected breeds of dog are inheriting «at risk» alleles for very few genes, perhaps even a single gene, with a profound effect.

Increasingly, specific genes, especially those that code for neurotransmitter synthesis and functions, are being identified that moderate parenting effects.

CONCLUSIONS: Early - onset antisocial behavior in a high - risk clinical group is predicted by a specific COMT gene variant previously linked with prefrontal cortical function and birth weight, and those possessing the val / val genotype are more susceptible to the adverse effects of prenatal risk as indexed by lower birth weight.