Sentences with phrase «specific gene in a mouse»

By manipulating a specific gene in a mouse blastocyst — the structure that develops from a fertilized egg but is not yet an actual embryo — scientists with the University of Florida's McKnight Brain Institute and the Harvard Stem Cell Institute caused cells destined to build an embryo to instead change direction and build the cell mass that leads to the placenta.

Not exact matches

Gene therapy delivered to a specific part of the brain reverses symptoms of depression in a mouse model of the disease — potentially laying the groundwork for a new approach to treating severe cases of human depression in which drugs are ineffective.

So far, gene therapy attempts have only resulted in partial improvements of hearing in mouse models of specific human deafness forms that did not include severe anomalies in hair cell structure.

The team manipulated the genome of mice such that they could initiate neuron death in the hippocampus by turning on specific genes.

Scientists had been searching in vain for such a gene since 1994 when Rockefeller University scientist Jeffery Friedman found that lab mice with a specific genetic mutation fail to produce leptin and as a result have uncontrollable appetites, and become huge.

Using a mouse model, the team also demonstrated that two processes during neurodevelopment are regulated by the gene: proliferation — the replication of neuronal stem cells that have the potential to become multiple different kinds of cells, including neurons — and migration — the movement of neurons to specific locations in the brain during development.

In their study, the researchers showed that already at the age of six weeks in the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other micIn their study, the researchers showed that already at the age of six weeks in the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other micin the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other mice.

«Understanding how gene editing works in human embryos will require research in human embryos,» because mouse embryos, for example, have species - specific developmental differences, notes Dana Carroll, a biochemistry professor at the University of Utah who researches CRISPR.

Functional analyses indicate that MFSD12 encodes a lysosomal protein that affects melanogenesis in zebrafish and mice, and that mutations in melanocyte - specific regulatory regions near DDB1 / TMEM138 correlate with expression of ultraviolet response genes under selection in Eurasians.

We not only introduced the gene into specific brain regions of the mouse, but we could also direct it to specific cell types to test which ones played a role in regulating sociability.»

Researchers find a full 12,000 genes that act differently in male and female mice, a finding that could lead to sex - specific medicine.

The researchers used tools of epigenomic analysis to trace the specific epigenetic switches controlling each of thousands of genes in both mouse and human retinal cells as the cells progressed through development.

The human - specific gene ARHGAP11B is expressed only in the right half of this embryonic mouse cerebral cortex.

This allowed them to identify specific genes that are turned on or off by co-regulators of gene function called TAZ and YAP in the nucleus of developing mouse Schwann cells.

Gene editing using CRISPR / Cas9, also can introduce mutations into specific organs or tissues in postnatal mice.

The researchers deliver a specific gene, which hitches a ride on a harmless virus, into the livers of mice, and once in the liver that gene codes for a protein called myelin oligodendrocyte glycoprotein.

In a scientific first, researchers at the Gladstone Institutes turned skin cells from mice into stem cells by activating a specific gene in the cells using CRISPR technologIn a scientific first, researchers at the Gladstone Institutes turned skin cells from mice into stem cells by activating a specific gene in the cells using CRISPR technologin the cells using CRISPR technology.

A group of scientists have described their use of a specific gene therapy to treat Alzheimer's disease in a mouse model.

Smithies was awarded the Nobel Prize in 2007 alongside Mario Cappecchi and Martin Evans «for their discoveries of principles for introducing specific gene modifications in mice by the use of embryonic stem cells».

The creator of the BAC - HD mice, William Yang at UCLA, cleverly modified the mutant HD gene he put in them, so that it could be turned off in specific brain regions.

A purified inactivated virus vaccine derived from a Puerto Rican strain was shown to induce ZIKV - specific neutralizing Abs and protect from virus challenge in mice and NHP models (115), and DNA vaccines encoding the prM / E genes of ZIKV elicited strong binding and neutralizing Abs in rhesus monkeys (116, 117).

We use what are called conditional knockout mice, in which a gene is deleted only in a specific organ or group of cells.

A specific type of brain activity important for memory replay is disrupted in mice with the E4 version of the apolipoprotein E (apoE4) gene, which may interfere with memory formation.

The researchers looked at the dentate gyrus, a specific area of the brain that is critical to memory and particularly vulnerable in Alzheimer's disease, and compared the genes that were turned on and off in normal mice and a mouse model of Alzheimer's disease.

For example the researchers used the CRE - ERT2 mouse model validated at the ICS, in which Cre function is controlled by the promoter of Atypical Notch ligand Delta - like homologue1 (Dlk1) under Tamoxifen activation, a skin fibroblast marker, to carry out temporal and tissue specific inactivation of key genes involved in skin fibroblast diversity.

The lab has generated «floxed» alleles of GABAA receptor subunit genes that allow us to ablate the respective subunit in a subregion specific manner — e.g., in hippocampal subregions or the amygdala — either via a cross with cre - transgenic mice or via stereotaxic injection of cre - expressing viruses into defined brain regions.

In Aim 1, we generate cell specific - knockout mice and characterize deletion of expression of distinct genes relevant to axon guidance.

We use the Cre - loxP recombination system to generate mice with cell type - specific inactivation of the IL - 10 gene in order to identify cellular sources of the cytokine that are relevant in various situations of immune challenge.

In the double mutant mice, the targeted gene is biotinylated, allowing for its specific immunoprecipitation and any bound proteins.

Besides information gathered to answer specific experimental questions, as determined by the interests of individual partners [35]--[41], the collective data offered the opportunity to search for coordinated gene expression patterns in a systematic exploration of the mouse ES transcriptome under a battery of different experimental settings, thus minimizing possible site - specific artifacts.

Genetic studies in humans and mice with idiopathic epilepsy have revealed a number of causative genes for specific forms of epilepsy 31.