Sentences with phrase «specific gene loci»

This essentially gives us «barcodes» of specific gene loci, which we can use to help untangle the complex genetics of complex diseases,» said Andrey Rzhetsky, PhD, professor of genetic medicine and human genetics at the University of Chicago, who led the study.

Not exact matches

The so - called SERPINB gene cluster on chromosome 18 was identified as a specific genetic risk locus for food allergies.

In their study, the researchers showed that already at the age of six weeks in the mice with a rapid weight gain, the DPP4 gene was less methylated at four specific loci, i.e. epigenetically altered, compared to the other mice.

The genomics era has had a profound impact on life science research, leading to significant developments such as the use of expression quantitative trait loci (eQTLs), which link polymorphisms in single genes to quantifiable changes in gene expression associated with specific diseases.

These regions can be clumped into larger areas of the genome called quantitative trait loci, which are known to contain genes that produce a specific physical effect, such as shaggy hair.

To demonstrate the critical role for ecRNA - directed methylation, first author Katherine Savell, a graduate student in the Day lab, blocked one specific ecRNA for the Fos gene locus in the hippocampus of the rat brain.

The locus sits close to an area of the genome where humans and chimps are known to share specific combinations of genes.

Despite evidence for divergence at several loci, certain 1a characteristics were preserved including the length of the alternative reading frame / F protein (ARF / F) gene, and a subtype 1a - specific phosphorylation site in NS5A (S349).

«It's hard to fit every single locus in the genome into one specific model of gene regulation.

Bivalent marking of loci encoding lineage specific transcription factors in ES cells is thought to prepare these genes for rapid activation of transcription once the pluripotency network is extinguished [4].

It is important to distinguish lineage specific gene expression shown here, which occurs at a high level and with a degree of specificity in the different population compartments, to the low level of genome wide transcription observed in ES cells by others [22], or with transcript initiation at many loci noted previously in ES cells [23].

Saturday, Oct. 21, 11:20 - 11:40 a.m., South Hall B, South Building Featured Plenary Abstract: Massively parallel reporter assays combined with cell - type specific expression quantitative trait loci profiling identified a functional melanoma risk variant in HIV - 1 inhibitor gene, MX2 J. Choi, National Cancer Institute, et al

With the premise that accumulation of putative resistance - conferring SNPs, potentially in combination with specific resistance genes, precedes full resistance, we retrogressively surveyed the hotspot loci and quantified the number of SNPs and / or genes, which if accumulated would confer full resistance to an otherwise susceptible strain.

The most basic genetic scenario is where a gene on a specific locus determines each trait.

Genes have pairs of alleles (one from each parent) that are located at specific sites (loci) on a chromosome.