Using advanced molecular screening tools, our scientists identify
the specific gene modifications that produce the desired effects in laboratory plants.
Smithies was awarded the Nobel Prize in 2007 alongside Mario Cappecchi and Martin Evans «for their discoveries of principles for introducing
specific gene modifications in mice by the use of embryonic stem cells».
Not exact matches
IRRI is using genetic
modification to help identify
specific genes within these DNA regions that are responsible for these traits.
Epigenetic
modifications label
specific regions of the DNA to attract or keep away proteins that activate
genes.
In the lycopene experiment, Church did not know which
modifications to make in the E. coli
genes to get the result he wanted, but the technique could just as easily be used to introduce
specific sets of changes into a genome, inserting and deleting hundreds or thousands of
genes at once.
When researchers want to study a
specific gene, they often make slight
modifications so a special protein tag that produces fluorescent light can attach to the proteins produced by their
gene of interest.
To modify these tagging vectors for your
specific gene, the lab recommends designing homology arms with the
modification of interest, ordering them from a
gene synthesis company such as IDT or Genscript, and cloning them sequentially into the chosen acceptor vector.
The sequential processes of somatic cell reprogramming to create patient -
specific hiPS cells, CRISPR / Cas9
gene editing, and single - cell cloning uniquely enable researchers to study how a
specific genetic
modification can influence function.
The MMRRC is your one stop resource for unique and popular research related mouse models offering
specific gene deletions, insertions,
modifications and repressions, and phenotypes.
The current report, which appears in the May 4, 2012 issue of the journal Cell Stem Cell, shows that these cells can also change their epigenomes, the patterns of DNA
modifications that regulate the activity of
specific genes — sometimes radically.
Stewart discovered that the histone
modifications that poise embryonic stem cell -
specific genes for activation are also found on the histones near
genes involved in regeneration, putting them into a ready - to - go state.
It has been shown that the induction of an altered phenotype by a maternal protein restriction diet during pregnancy involves changes in DNA methylation and histone
modifications in
specific genes, including the glucocorticoid receptor (GR)(33 % lower; P < 0.001) and PPAR?
The most common seed
modifications are
genes that kill caterpillars and make the plant resistant to a
specific herbicide; for example, Monsanto create plants that are resistant to Roundup, which they also own.