Sentences with phrase «specific gene sequences»

The specific gene sequences which had evolved in the British birds were found to closely match human genes known to determine face shape.

One general benefit of the RNAi approach, Zhang says, is that researchers can selectively target specific insect pests by targeting species - specific gene sequences; this avoids the blanket destruction of other insect species seen with many insecticides, he explains.

By using sequences of RNA that match specific gene sequences in a pest, RNAi should leave other species unscathed.

Significant differences were also discovered between the centenarians and the two control groups when their genotype frequencies were compared, in other words, the proportion of individuals with a specific gene sequence.

For instance, services like 23andMe use genotyping to zoom in on a selection of important DNA base pairs, while specific gene sequencing provides data on particular bases.

The Guardian article of August 21, 2015 describes the changes in a specific gene sequence associated with the regulation of stress hormones.

Not exact matches

In sequencing of the human genome, we learned that diseases rarely correlated to specific human genes.

While all cells in a specific organism share the identical DNA sequence, only a fraction of those genes are activated in a given cell type.

«It's a type of molecule called an antisense oligonucleotide, or ASO, that essentially is synthetic string of nucleic acid that binds a specific sequence in the gene.»

An international team led by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a new technique for identifying gene enhancers — sequences of DNA that act to amplify the expression of a specific gene — in the genomes of humans and other mammals.

CRISPR - Cas9 is a versatile and highly accurate gene - editing technology that allows researchers to modify specific parts of an organism's genome by altering sections of the DNA sequence.

However, the results of more recent phylogenetic analyses, derived from comparisons between sequences of specific genes and of whole genomes, seemed to point to Ctenophora as the first group that parted company with the lineage from which the rest of the animal kingdom (including sponges) evolved.

Lu's team will extract immune cells called T cells from the blood of the enrolled patients, and then use CRISPR — Cas9 technology — which pairs a molecular guide able to identify specific genetic sequences on a chromosome with an enzyme that can snip the chromosome at that spot — to knock out a gene in the cells.

Using a combination of old - fashioned clinical observation and modern biochemical analysis, he has shown that a person's appetite and their eating behavior can be linked to specific genes — and that even a tiny defect such as the absence of a single nucleic acid in a sequence of DNA can lead to runaway weight gain.

In this study that used deep DNA sequencing of bacterial specific genes, the guts of both males and females exposed to lead had all of the similar complexity in microbiota as those not exposed.

In addition, it binds to the promoter sequences (dark blue) of specific target genes including mitochondrial fission process 1, MTFP1.

Berninger and others have previously shown that Sox2, Ascl1, and other transcription factors — proteins that bind to specific DNA sequences to control the activity of genes — can induce the nonneuronal «support cells» known as glia to turn into neurons.

«We are unpacking the entire DNA sequences of 50 influential animals then honing in on the genes associated with specific traits in order to capture the best genetics in the Brahman breed,» he said.

Conventional genetic screening looks for specific mutated sequences of DNA, but the Dutch test simply searches for proteins which are shorter than those produced by healthy genes.

Over the longer term, the identification of the coffee tree genome sequence opens up new possibilities for varietal improvement, knowledge of the specific functions of the genes (in particular those specific to coffee trees), the possibility of transferring results to other species, and refining diagnostic tools for the function of the plant.

Epigenetic changes do not alter the information encoded in the DNA sequence itself but determine whether and to what extent specific genes are used by cells.

Hadfield echoes Besnard's suggestion to amplify and sequence specific genes rather than whole genomes, if that will answer the research question.

They used a technique called next generation sequencing (NGS) to detect specific bacterial genes.

The genome - editing technique known as CRISPR allows scientists to clip a specific DNA sequence and replace it with a new one, offering the potential to cure diseases caused by defective genes.

His specific mutation subtly affects the slicing of the gene and doesn't affect the amino acid sequence that synthesizes the ZAP70 protein.

Thus transformation provides an in vivo assay for the functional role of DNA sequence organization about specific genes.

It is true that a particular gene of an Avidian that evolved to perform the software operation called equals is complex in this sense — a specific, complex sequence of instructions produces the function.

Molecular markers — pieces of DNA that «mark» a specific gene — allow researchers to comb the genetic blueprint of a plant, match the sequence with a certain trait using computer programs, and develop seeds.

«We found global increases in many dozens of genes,» says Tavazoie, «so we analyzed their sequences and found that the majority of them had significantly increased numbers of these two specific codons.»

SEATTLE — Apparently ending several years of uncertainty, an official of the U.S. Patent and Trademark Office (PTO) revealed here today that the government intends to grant patents on expressed sequence tags (ESTs), human DNA sequences of up to a few hundred base pairs in length that can be used to identify and detect the expression of specific genes.

Pugh and Venters further validated their surprising findings by determining that these non-coding initiation machines recognized the same DNA sequences as the ones at coding genes, indicating that they have a specific origin and that their production is regulated, just like it is at coding genes.

TAP recognizes and binds to a specific DNA sequence upstream of the gene.

Extensive research has already examined the function of microRNAs, a category of small evolutionarily conserved noncoding RNAs about 22 to 24 nucleotides in length that target protein - coding genes in a sequence - specific manner.

The Rutgers scientists show that the transcription activator protein functions by binding to a specific DNA sequence preceding the target gene and making adhesive, Velcro - like interactions with RNA polymerase that stabilize contacts by RNA polymerase with adjacent DNA sequences.

During development, chromosomes are subject to chemical changes that don't affect the nucleotide sequence but can turn genes on or off; the best known example is methylation, in which a methyl group is attached to specific DNA regions.

The researchers» next step is to use the genomic data they collected from the families — including full genome sequences and gene expression data — to begin identifying the specific genes that contribute to risk for bipolar disorder.

Furthermore, besides offering valuable insight into the function of this novel RNA type, the researchers also believe that the findings will open new avenues for novel treatments in which cell - specific enhancer sequences can be targeted to alter gene expression.

The study, «Transcriptome Sequencing Implicates Dorsal Striatum - Specific Gene Network, Immune Response and Energy Metabolism Pathways in Bipolar Disorder,» [http://www.nature.com/mp/journal/vaop/ncurrent/full/mp201694a.html] was supported by funding from the State of Florida.

This type of histone methylation enables the function of these regions as enhancer sequences, i.e. as marks that can be identified by specific proteins which boost gene transcription.

Huntington's disease is caused by the abnormal repetition of a specific DNA sequence at the tail end of the huntingtin gene.

By focusing on several of these mutations and screening through guide RNA variants with different mismatch combinations, they were able to identify specific guide RNAs that stimulated Cas9 activity towards the mutated gene sequences but left the normal counterpart untouched.

The mfd gene was cloned and sequenced and the Mfd protein was purified and used to reconstitute strand - specific repair in a completely defined system.

They sequenced microbe - specific genes collected from the animals» stool to determine the gut microbiome makeup of each mouse type, with or without blocked gastric acid production.

This strict selectiveness of sensory neurons is in part due to enhancers (DNA sequences that enhance transcription of a gene when bound by specific protein), which remain poorly understood.

If variation of the sequence of a specific gene is greatly reduced in modern versions, this is considered a sign that it was shaped by the selective pressures of domestication.

«Understanding how Cas9 is able to locate specific 20 - base - pair target sequences within genomes that are millions to billions of base pairs long may enable improvements to gene targeting and genome editing efforts in bacteria and other types of cells,» says Doudna who holds joint appointments with Berkeley Lab's Physical Biosciences Division and UC Berkeley's Department of Molecular and Cell Biology and Department of Chemistry, and is also an investigator with the Howard Hughes Medical Institute (HHMI).

And while scientists have had some success in switching off genes by inserting or deleting random sequences, they have not yet been able to use CRISPR / Cas9 to paste in (or «knock in») specific new sequences to correct mutations in T cells.

Moreover, the ability to easily program sequence - specific DNA targeting and cleavage by CRISPR - Cas components, as demonstrated for Cas9 and Cpf1, allows for the application of CRISPR - Cas components as highly effective tools for genetic engineering and gene regulation in a wide range of eukaryotes and prokaryotes.

«This time we sequenced the families for this specific CLP1 gene mutation and all had it,» said Karaca.

The Yale - led study performed whole exome sequencing ¬ — a technique for sequencing all the expressed genes in a genome ¬ — on TNBC tumors to identify mutations in specific genes or pathways that may indicate response or resistance to the standard of care, which is anthracycline / taxane (ACT) chemotherapy.