The scientists correlated disease outcomes and variations in mortality rates to
specific genetic lines of mice.
Not exact matches
Yesterday, another Harvard team announced that it had generated disease -
specific cell
lines for nine other
genetic diseases, including Parkinson's disease.
Separate
lines of work show that
specific genetic variations are linked to higher levels of some fatty acids (molecular building blocks of fat) in the bloodstream.
These «pluripotent cell
lines» will be especially groundbreaking for studying Gulf War Illness, because they preserve the
genetic and possibly epigenetic factors
specific to disease susceptibility.
On the other hand, breeders who are producing mixed breeds might have a bias against purebreds because they believe the rate of inbreeding and
line breeding in a closed gene pool (when breeders stick to only breeding dogs registered with a
specific kennel club, that breed's gene pool is most likely closed) will create a
genetic bottleneck.
Research
specific lines within your breed and familiarize yourself with their
genetic history, health problems, drives, work vs show?
This means that while there may be lots of
genetic diversity among all dogs, only the
specific versions of those genes possessed by the small number of founders will be part of the new
line.
An inherited early - onset form of diabetes characterized by abiotrophy of islet β - cells in a
line of Keeshond dogs (128), is a rare example of an «other
specific type» of canine diabetes and presumably has a
genetic basis.
The loss of
genetic diversity in purebred dogs can be attributed to two major population bottleneck events: the first occurring during domestication; and the second arising from breed formation where the repeated use of popular sires,
line breeding, breeding for
specific phenotypic traits, and promotion of the breed barrier rule, contributed to overall loss in
genetic variation [15 - 19].