Confirmation that
a specific haplotype of the dopamine transporter gene is associated with combined - type ADHD
For efficient mapping of these mutants and mutation identification, we devised a new mapping strategy based on identification of mutant -
specific haplotypes.
Specific haplotypes have been associated with an increased risk for the development of diabetes and auto immune diseases in humans.
Not exact matches
This requires the development of powerful bioinformatic approaches that allow prediction of
haplotypes from numerous variants, and the classification of
haplotypes into functionally related categories, in order to identify those
specific sequence variants, or combinations of variants, associated with the disease phenotype.
Often — but not always — a
haplotype will point toward a more
specific geography, like Japan or southern India.
Within this gene, the deCODE team identified
haplotypes, or
specific sets of genetic markers, that correspond both to significantly increased risk of stroke and to significantly decreased risk.
Genetic variation at the eNOS locus is associated with diabetes, which may be attributable to an enhanced effect of total energy expenditure on glucose disposal in individuals with
specific eNOS
haplotypes.
Earlier, I mentioned how the generation of dog breeds has caused large stretches of DNA to be placed under positive selection, generating breed
specific «
haplotypes.»
Specific assortments of MHC alleles or
haplotypes have been associated with an increased risk for the development of diabetes and auto immune diseases in humans.
Specific assortments of MHC alleles, comparable to 7 beads of different colors on a string, constitute a
haplotype.