Sentences with phrase «specific human cancer»
It was the first genetic defect linked with a specific human cancer.
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TruePrime - mediated circulating tumor DNA amplification specifically selects the larger, more cancer - specific DNA fragment - size population from human plasma.
While testing the effect of many normal, non-cancerous, human cells on the sensitivity of cancer cells to chemotherapy, they found a specific sample of normal human skin cells that rendered pancreatic cancer cells resistant to gemcitabine.
«This phenomenon is one likely explanation for the human - specific negative impact of excessive red meat intake and its association with cancer, atherosclerosis and other inflammatory processes,» Varki says.
Human chondrosarcoma HCS - 2 / 8 cells, which are a type of benign bone cancer cells, can be used to investigate how optimization of culture conditions could improve the synthesis of cartilage - specific molecules.»
There is sufficient human evidence linking KSHV to several cancers, including Kaposi sarcoma, and two rare lymphomas — primary effusion lymphoma and a specific plasmablastic variant of multicentric Castleman disease.
In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.
The title of the paper is «Bioinformatic analysis reveals a pattern of STAT3 - associated gene expression specific to basal - like breast cancers in human tumors.»
«This is the first time that this specific protein - protein signaling complex has been identified in GBM, and it gives us a new potential target for drug development,» says Fisher, Thelma Newmeyer Corman Endowed Chair in Cancer Research and co-leader of the Cancer Molecular Genetics research program at VCU Massey, professor and chair of the Department of Human and Molecular Genetics at the VCU School of Medicine, and director of the VIMM.
The program works by connecting computer - generated drug profiles — including mechanisms of action, clinical efficacy, and side effects — with information about how a molecule may interact with human proteins in specific diseases, such as ovarian cancer.
The light - activated genetic switch could be used to turn genes on and off in gene therapies; to turn off gene expression in future cancer therapies; and to help track and understand gene function in specific locations in the human body.
Dr. Gnjatic's research focuses on human antigen - specific immune responses to tumor antigens, in an attempt to define new targets for the development of cancer immunotherapies, assess the efficacy of these immunotherapies, and learn why they may fail.
Over the past two years, investigators from the Perelman School of Medicine at the University of Pennsylvania have reported results from a human trial in GBM using chimeric antigen receptor (CAR) T cell therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.
«Identifying specific signatures of ribonucleotide incorporation in DNA may represent novel biomarkers for human diseases such as cancer, and other degenerative disorders.»
However, scientists at SFU, the University of British Columbia and the B.C. Cancer Agency have discovered that many non-coding RNAs are perturbed in cancerous human cells, including breast and lung, in a specific way.
«It's intriguing that we are now seeing evidence of evolutionary adaptation in these specific shark immunity genes, which just happen also to be involved in promoting cancer in humans.»
Daniel E. Speiser and coworkers demonstrate that human cancer - specific cytotoxic CD8 T cells are strongly activated after vaccination with peptides and CpG oligonucleotides, representing the currently most powerful synthetic cancer vaccine formulation.
Being both tumor - specific and widely expressed in human tumors, MAGE - A3 is an ideal cancer vaccine target and will be the focus of many clinical trials, including the largest clinical trial ever conducted in lung cancer, MAGRIT, launched by GlaxoSmithKline in 2007.
Specific association of human telomerase activity with immortal cells and cancer.
Species - specific homing mechanisms of human prostate cancer metastasis in tissue engineered bone.
Tags: Acute Myeloid Leukemia, Andrew Hsieh, Basic Sciences, Clinical Research, Harmit Malik, Human Biology, Jesse Bloom, Marie Bleakley, Prostate Cancer, Transplant and Immunotherapy, Tumor specific translational research, Vaccine development - Viral cancers
MD Anderson is working closely with Guardant to expand a highly specialized CLIA - accredited lab (CLIA labs comply with federal standards known as the Clinical Laboratory Improvement Amendments that regulate all clinical laboratory testing on humans), and pre-CLIA labs, where Guardant's digital sequencing technology will be used to create disease - specific assays that will be transferred for use in the CLIA - accredited lab to help detect cancers early and guide treatment.
Over the last 3 years, the partnership between the Salk Institute and Ipsen has delivered significant scientific advances in the cancer field such as the development of biological models mimicking human cancerous processes as well as identification of specific cells driving tumor growth.
This laid the groundwork for studies on the molecular causes of this specific cancer type that would be impossible in humans.
T cell exclusion, which also occurs in several types of human adenocarcinomas, causes antagonists of T cell checkpoints to be ineffective, despite the presence of cancer - specific CD8 + T cells.
Tags: Acute Myeloid Leukemia, Anne McTiernan, cancer prevention, Computational Biology, exercise, genetic mutation, Harlan Robins, Human Biology, Lung Cancer, national science foundation, obesity, Pancreatic Cancer, physical activity, Public Health Sciences, stand up to cancer, Tumor specific translational recancer prevention, Computational Biology, exercise, genetic mutation, Harlan Robins, Human Biology, Lung Cancer, national science foundation, obesity, Pancreatic Cancer, physical activity, Public Health Sciences, stand up to cancer, Tumor specific translational reCancer, national science foundation, obesity, Pancreatic Cancer, physical activity, Public Health Sciences, stand up to cancer, Tumor specific translational reCancer, physical activity, Public Health Sciences, stand up to cancer, Tumor specific translational recancer, Tumor specific translational research
Tags: aspirin, Bezos, bioengineering, Breast Cancer, Cameron Turtle, Cancer etiology - prevention - outcomes, CAR t - cell, Clinical Research, Colorectal Cancer, genome, hiv, hiv vaccine, hiv vaccine trials network, Human Biology, immunology, Jason Bielas, Lawrence Corey, Matthias Stephan, merkel cell carcinoma, metastasis, Molecular basis of cancer, mylotarg, Obliteride, Paul Nghiem, philanthropy, Polly A Newcomb, Public Health Sciences, RNA, Ruth Etzioni, Soheil Meshinchi, Steven Henikoff, Transplant and Immunotherapy, Tumor specific translational research, Vaccine and Infectious Disease, Vaccine development - Viral cCancer, Cameron Turtle, Cancer etiology - prevention - outcomes, CAR t - cell, Clinical Research, Colorectal Cancer, genome, hiv, hiv vaccine, hiv vaccine trials network, Human Biology, immunology, Jason Bielas, Lawrence Corey, Matthias Stephan, merkel cell carcinoma, metastasis, Molecular basis of cancer, mylotarg, Obliteride, Paul Nghiem, philanthropy, Polly A Newcomb, Public Health Sciences, RNA, Ruth Etzioni, Soheil Meshinchi, Steven Henikoff, Transplant and Immunotherapy, Tumor specific translational research, Vaccine and Infectious Disease, Vaccine development - Viral cCancer etiology - prevention - outcomes, CAR t - cell, Clinical Research, Colorectal Cancer, genome, hiv, hiv vaccine, hiv vaccine trials network, Human Biology, immunology, Jason Bielas, Lawrence Corey, Matthias Stephan, merkel cell carcinoma, metastasis, Molecular basis of cancer, mylotarg, Obliteride, Paul Nghiem, philanthropy, Polly A Newcomb, Public Health Sciences, RNA, Ruth Etzioni, Soheil Meshinchi, Steven Henikoff, Transplant and Immunotherapy, Tumor specific translational research, Vaccine and Infectious Disease, Vaccine development - Viral cCancer, genome, hiv, hiv vaccine, hiv vaccine trials network, Human Biology, immunology, Jason Bielas, Lawrence Corey, Matthias Stephan, merkel cell carcinoma, metastasis, Molecular basis of cancer, mylotarg, Obliteride, Paul Nghiem, philanthropy, Polly A Newcomb, Public Health Sciences, RNA, Ruth Etzioni, Soheil Meshinchi, Steven Henikoff, Transplant and Immunotherapy, Tumor specific translational research, Vaccine and Infectious Disease, Vaccine development - Viral ccancer, mylotarg, Obliteride, Paul Nghiem, philanthropy, Polly A Newcomb, Public Health Sciences, RNA, Ruth Etzioni, Soheil Meshinchi, Steven Henikoff, Transplant and Immunotherapy, Tumor specific translational research, Vaccine and Infectious Disease, Vaccine development - Viral cancers
He later combined it with studies on chromatin, tissue specific gene expression and mouse models for human diseases including Type II diabetes, polycystic kidney disease as well as cancer.
He and his colleagues were the first to demonstrate that human antigen - specific T cell clones could be isolated and expanded in vitro and then re-infused into patients to prevent or treat viral infections and to mediate therapeutic responses in patients with cancer.
CAR - T cells are human killer T cells artificially engineered to target specific proteins (antigens) associated with a cancer.
Matsuzaki J, Gnjatic S, Mhawech - Fauceglia P, Beck A, Miller A, Tsuji T, Eppolito C, Qian F, Lele S, Shrikant P, Old LJ, Odunsi K. (2010) NY - ESO - 1 specific tumor infiltrating CD8 + T cells in human ovarian cancer: negative regulation by LAG - 3 and PD - 1.
We can envision that DAXX can serve as a precise prognostic marker in PCa and that tissue - specific shRNA delivery targeted against DAXX can be employed in the treatment of metastatic prostate cancer in patients, in particular if we discover, through additional studies, that DAXX is a marker for lethal PCa in humans.
The project focuses on the study of human breast cancer cells, particularly if and how CNPs can target and deliver medication to specific cells.
Tags: cancer genomics, Carla Grandori, Christopher J Kemp, Clinical Research, Eddie Mendez, Good News, head neck cancers, Human Biology, Jerald P Radich, personalized treatment, precision medicine, Tumor specific translational research, Vijayakrishna Gadi
Activity of the APOBEC enzymes has been linked to specific mutational processes in human cancer genomes.
Azacytidine and Decitabine induce gene - specific and non-random DNA demethylation in human cancer cell lines
Although no specific dosage for humans has been determined yet, it seems that maintaining a minimal amount of apigenin in the bloodstream is beneficial for delaying the onset of breast cancer which progresses as a result of progestins like MPA.
In addition, several case - control studies have shown that specific forms of the gene that encodes glutathione S - transferase, which is the enzyme that metabolizes and helps eliminate isothiocyanates from the body, may influence the association between cruciferous vegetable intake and human lung and colorectal cancer risk (21 - 23).
There are other extremely specific — and extremely spoiler - y — details from the other books that make up the spine of film: for instance, that the psychologist Dr. Ventriss (Leigh) is dying of cancer; that she's actually the director of the Southern Reach; that this whole Area X business possibly started when a comet hit the lighthouse; and that there are aliens that can create human clones that they send out into the world.
Samples from canine patients will not only allow the researchers to identify genes responsible for breed - specific susceptibilities (such as hemangiosarcoma in Clumber spaniels and osteosarcoma in Greyhounds), but also to translate these discoveries into new and more precise diagnostics and therapeutics for both canine and human cancer patients.
The purpose of these trials is to learn more about the specific type of treatment (that may be of value to humans and other pets with cancer), as well as hopefully providing a benefit to your pe
In humans, there is an antibody specific to prostate cancer that can be measured in the blood.