Sentences with phrase «specific immune cell»

The team used a specific mouse strain that is healthy but it is lacking in a specific immune cell receptor, which makes the mouse unable to reject transplanted foreign cells.

Cell markers are helpful tools used to identify a specific immune cell population.

More recent work by Aggarwal and Pittenger 82 supported the feasibility of MSC - transplantation showing that MSC altered the phenotypes of specific immune cell subtypes thereby creating a tolerogenic environment.

«Our data suggests that targeting specific immune cell subsets at defined stages of disease may represent a better approach to therapeutic immunomodulation to improve heart failure.»

Human milk is a bodily fluid which, apart from being an excellent nutritional source for the growing infant, also contains a variety of immune components such as antibodies, growth factors, cytokines, antimicrobial compounds, and specific immune cells [9].

The acceleration of the healing process occurs due to changes in the microenvironment in the wound, which change the behaviour of specific immune cells.

The most common type of skin lymphoma is caused by the fact that specific immune cells — CD4 - T - lymphocyttes — turn into cancer cells.

Davis will use his findings to figure out a way to match specific immune cells to vaccine response.

Specific immune cells have the ability to produce a healing factor that can promote wound repair in the intestine, a finding that could lead to new, potential therapeutic treatments for inflammatory bowel disease (IBD), according to a new research study.

The Leuven - based VIB researchers have revealed a mechanism that explains why the anti-tumor activity of specific immune cells called macrophages is suppressed during tumor growth.

The third approach turns up production of T regulatory cells, which prevent specific immune cells from copying themselves and can also suppress rejection by secreting biochemicals called cytokines that direct the immune orchestra to change its tune.

The researchers also analyzed specific immune cells called cytotoxic T cells isolated from the patients» blood and found increases in biomarkers indicative of immune activation.

Inhibitory control Other strategies being pursued to prevent the formation of inhibitors of clotting - factor therapy include immunosuppressants and drugs that deplete specific immune cells.

These cells, in turn, instruct factor - VIII — specific immune cells to become tolerant to the coagulation protein, resulting in suppression of misdirected antibody responses to the replacement therapy — all without affecting the rest of the immune system.

Results showed that antibodies were able to bind to the cancer cells and recruited specific immune cells called natural killer cells, resulting in shrinkage of the tumor, significantly improving survival.

In their work, the scientists were able to demonstrate that the transfer of just a few specific immune cells is sufficient to protect the recipient with the weakened immune system against infections.

«It's long been known that people with HIV infection have a lot of HIV - specific immune cells that one would think would be actively combating the virus,» Walker says.

Led by CU - Boulder Assistant Research Professor Peter Grace and Distinguished Professor Linda Watkins, the study showed that just a few days of morphine treatment caused chronic pain that went on for several months by exacerbating the release of pain signals from specific immune cells in the spinal cord.

New research into Amyotrophic Lateral Sclerosis (ALS)-- also known as motor neuron disease — shows that specific immune cells may help slow progression of the disease, an important step towards developing new therapies to treat patients.

These 45 variants are significantly enriched for protein - coding changes (n = 13), direct disruption of transcription - factor binding sites (n = 3), and tissue - specific epigenetic marks (n = 10), with the last category showing enrichment in specific immune cells among associations stronger in Crohn's disease and in gut mucosa among associations stronger in ulcerative colitis.

Exercise has been shown to decrease stress and increase specific immune cells in the body that are responsible for destroying viruses and bacteria.

Specific immune cells known as CD8 + T cells are needed to fight off the Epstein - Barr virus, however, some individuals may have a low baseline level of these types of immune cells.

Not exact matches

So research teams began souping up various types of immune cells and even targeting them to specific protein markers on tumors.

The treatment is a type of so - called CAR T - cell therapy — taking a patient's own immune cells, called T cells, genetically manipulating them to attack specific proteins on cancer, and infusing them back into the patient.

Those two companies, along with their larger competitor Novartis (nvs), are developing experimental chimeric antigen receptor T - cell (CAR - T) technology platforms, which are highly personalized treatments that involve extracting patients» immune cells, re-engineering them to target their specific cancers, and then pumping these sniper - cells back into the body.

According to a team of researchers led by Dr. Michael Julius, a specific protein in breast milk, CD14, helps jump start an infant's immune system and develop essential B cells, which are instrumental in the development of antibodies.

Specific maternal immune cells in the milk cross the wall of the baby's intestine to enter an immune organ called the thymus.

We found that when it comes to cutaneous immunity — specific to skin — the immune system was being obstructed by skin cells that were too prone to producing inflammation responses.

The scientists hope understanding how immune cells adapt as they enter different tissues will spur the design of better, more specific, medicines.

Previously, Derek Danahy of the University of Iowa and colleagues showed that sepsis disrupts the immune system by reducing the amount and function of memory T cells that circulate throughout the body, recognizing and attacking specific bacteria, viruses, or cancer cells.

Taking a closer look, the team found that the onset of sepsis disrupts the normal activity of specific interferons, signaling proteins used for communication between immune system cells.

Chronic HIV infection results in exhaustion of the immune system, a phenomenon characterized by dysfunctional HIV - specific killer T cells.

With our human gut - on - a-chip, we can not only culture the normal gut microbiome for extended times, but we can also analyze contributions of pathogens, immune cells, and vascular and lymphatic endothelium, as well as model specific diseases to understand complex pathophysiological responses of the intestinal tract.»

This drug (vedolizumab) blocks a specific adhesion molecule on the surface of the T - cell and thereby inhibits immune cells from binding themselves to receptors present in the intestine, preventing the T - cells from penetrating the blood vessels in the intestinal tissue.

The sex - specific differences — the smaller hippocampus, the presence of fewer nerve cells, the existence of immune system macrophages in places they shouldn't be — were also found in adulthood.

In reaction to infection or inflammation, immune system cells known as effector T cells (Teffs) undergo rapid changes - arming themselves and diversifying into groups that target specific diseased cells.

We are not just talking about the T cells and B cells that are specific for HIV or SIV, we are talking about the vast majority of all immune cells in the body.

In a paper published in the current online issue of the journal Small, titled «Immune Cell - Mediated Biodegradable Theranostic Nanoparticles for Melanoma Targeting,» the researchers report the use of a novel biodegradable and photoluminescent poly (lactic acid) nanoparticle, loaded with melanoma - specific drugs with immune cells as the nanoparticle carriers.

When the researchers added a little of this bacterial byproduct to the mix, Fel d 1 activated a specific immune receptor on cells, called Toll - like receptor 4 (TLR4).

Lu's team will extract immune cells called T cells from the blood of the enrolled patients, and then use CRISPR — Cas9 technology — which pairs a molecular guide able to identify specific genetic sequences on a chromosome with an enzyme that can snip the chromosome at that spot — to knock out a gene in the cells.

Researchers at Penn State have combined the two approaches by taking biodegradable polymer nanoparticles encapsulated with cancer - fighting drugs and incorporating them into immune cells to create a smart, targeted system to attack cancers of specific types.

Although Coley couldn't explain precisely why or how his toxins worked, modern immunotherapy treatments help T - cells in the immune system to recognize specific cancer cells and attack them.

Essentially, it mimics the disease so that the immune cells recognize it, and the body stocks up on the immune cells with a barcode specific for that disease.

In this study, the researchers found that a specific population of immune cells called macrophages have the ability to secrete or produce a protective or healing factor known as Interleukin - 10 (IL - 10), which can interact with receptors on intestinal epithelial cells to promote wound healing.

While the individual effects of the drugs on virus - specific CTL differ somewhat depending on specific assays, schedules, and doses, treatment with any of the three HDAC inhibitors impaired the ability of CTL to kill HIV - infected immune cells.

To better understand how this abnormal distribution of B cell types in people with uncontrolled HIV affected their immune response to the virus, researchers compared HIV - specific antibodies derived from both TLM and RM B cells.

«Unlike previous studies we isolated different immune cell types from the actual site of disease to determine whether specific subsets of immune cells (specific T cell groups) have equal sensitivity to vitamin D.»

T cells, along with B cells and others, comprise the adaptive arm of the immune system, the body's second line of defense which quickly attacks and «remembers» specific pathogens.

The National Cancer Institute is now funding a study to determine what specific characteristics led to that trial's success, comparing two sets of modified immune cells in patients.

Patients who develop this specific fungal infection are overwhelmingly adults who are immunocompromised, Kumar explains, including those with diabetes, transplant recipients, patients with cancer and those who have abnormally low concentrations of immune cells called neutrophils in their blood.