Sentences with phrase «specific immune mechanisms»
Immune abnormalities in patients with psychosis have been recognized for over a century, but it has been only relatively recently that scientists have identified specific immune mechanisms that seem to directly produce symptoms of psychosis, including hallucinations and delusions.
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Based on a defense mechanism in the immune system of bacteria that hunts and destroys invading viruses, CRISPR can locate and replace specific genes.
The Leuven - based VIB researchers have revealed a mechanism that explains why the anti-tumor activity of specific immune cells called macrophages is suppressed during tumor growth.
He also studies the mechanisms of antigen presentation to T cells, the impact of immunoregulation on tumor antigen - specific responses, and characterization of the tumor - immune microenvironment.
She is investigating the role of glycosylated molecules in tumor progression and metastasis, tissue - and species - specific expression of lectin receptors that play a role in regulating host innate immune responses and inflammation, and the immunological mechanisms underlying chronic inflammation and cancer development.
In the last few years, scientists in Southampton have been at the forefront of research into the role of the immune system in Alzheimer's, so it is encouraging to see this study taking these ideas forward by identifying a specific mechanism that could be a target for future treatments.
The main mechanism includes phagocytosis of macrophages which play a critical role in nonspecific defense (innate immunity) and, moreover; they have a role as antigen presenters which also help initiate specific defense mechanisms (adaptive immunity) by recruiting other immune cells such as lymphocytes.
The first of its kind, the study provided specific markers to distinguish different disease states in asthma and paved the way for investigating the role of epigenetic mechanisms in other immune - mediated disorders and infectious diseases.
Properly engineered immune cells could enable scientists to direct highly specific, long - lasting immune response mechanisms against a disease.
Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.
Through long - established collaborations in Durban and Kimberley, these studies in particular seek to define: the immune responses that are effective in control of HIV infection; the impact of HLA - mediated selection pressure on HIV at the individual and population level; the mechanisms of HIV non-pathogenicity; the nature and consequences of ontogeny of the virus - specific immune response; and finally the prospects for interventions including antiretroviral therapy, alone or in combination with broadly neutralising antibodies and / or T - cell vaccines, to achieve HIV eradication.
Little research has been performed to understand the specific rules and mechanisms of minimal residual disease, including clonal evolution at the metastatic site, epigenetic programs, interaction with organ defense and immune systems, mechanisms of dormancy and re-awakening, and last but not least, mechanisms of therapy resistance in specific niches.
These tests will suggest the specific immune and genetic causes of ITP, so targeted drugs can be developed that suppress just these mechanisms, not the whole immune system.
However in most cases it is not possible to indicate a specific cause and» the condition is referred as chronic idiopathic hepatitis, in which a immune - mediated mechanism is supposed, at least in part, to be involved in the pathogenesis.