Sentences with phrase «specific immune pathways»

Identifying any Hymenoptera - specific immune pathways or effectors that may exist is also of key importance for understanding the biology of host - pathogen interactions that may be relevant for such challenges as colony collapse disorder [42]--[44].

The study examined specific immune pathways known to be activated during flu infections in both humans and mice, which makes the findings relevant to children.

Not exact matches

«Rather than using an immune method or targeting an enzyme, which have side effects, we want to target this specific pathway so that the brain can naturally clear amyloid - beta peptides when they're not trapped by heparan sulfate,» says Guojun Bu, a neuroscientist at Mayo Clinic in Jacksonville, Fla., and the study's lead author.

Although drugs to block the PD - 1 pathway have been developed for cancer patients, they affect all immune cells, not just HIV - specific ones.

This and other studies suggest that DDT and the other pesticides may alter not only specific genes but also pathways of genes that collectively control the immune system or other systems that can be altered by chemicals.

By blocking a specific cell signaling pathway in lab animals, researchers reversed signs of chronic immune activation, thereby boosting T - cell recovery and viral suppression.

In recent years, researchers have developed so - called «senolytic» drugs that wipe out senescent cells in aging mice and mouse models of age - related disease, exploiting the high dependence of these cells on specific biochemical survival pathways.9, 10 In these studies, senolytic drugs have restored exercise capacity9 and formation of new blood and immune precursor cells11 in aging mice to near youthful norms, and prevented or treated mouse models of diseases of aging like osteoarthritis, 12 fibrotic lung disease, 13 hair loss, 14 atherosclerosis, 15,16 and age - related diseases of the heart itself.9 UNITY Biotechnology is leading a growing charge toward the clinic, with human clinical trials expected to begin in 2019.

8.30 Hana Paculová CDK12 connects transcriptional regulation to DNA damage repair pathway 8.55 Karol Kaiser Wnt secretion during nervous system development 9.20 Simona Hankeová The role of Notch signaling in vasculogenesis 10.00 Coffee break 10.30 Tomáš Doležal Extracellular adenosine regulates complex host - pathogen interactions through the energy release for the immune response 10.55 Ondřej Bernatík and Igor Červenka Regulation of diverse function of Dvl by phosphorylation 11.20 Jan Ryneš Dissection of Axin interactome: rational approach for control of signaling cascades via intervention with specific protein - protein interactions 12.05 Targeting opportunities: discussion & sum - up 13.00 Lunch and departure

While not all genes with an immune function will necessarily be regulated by any specific infection, and thus an RNA - seq - based catalog of immune - related genes can not be expected to be complete, it has the significant advantage of being unbiased by assumptions about conservation of genes across species, and thus serves as a valuable starting point for comparative analysis of the evolution of immune pathways.

Therefore the group studies with sophisticated imaging technology in vitro and ex vivo: i) the molecular mechanism driving the migration of HIV through the intestinal epithelial barrier; ii) the cellular targets in the mucosa, in specific macrophages and DCs, to identify the possible pathways to invade the tissue and disseminate to other organs; iii) the involvement of DCs and their functional properties in mediating adaptive immune responses at mucosal level; and iv) the role of antibodies with different effector functions in changing the pathways of the virus.

Recent studies show that this property can be exploited for the delivery of fused antigens into the major histocompatibility complex class I - restricted presentation pathway, with the goal of eliciting a specific immune response.

• New human - specific biomarker identification and new drug discovery is possible using Organ - Chips, based on new insights into biological pathways of disease and immune system interaction.

As anticipated, since we are working with blood samples, the inflammatory and immune response categories with specific signaling pathway such as cytokines signaling between immune cells, IL - 6 and IL - 10 signaling were identified in our analysis.

Specific canonical pathways enriched with such genes included PPAR signalling, cytokine signaling between immune cells and G - protein coupled receptor signalling (Table S2).