Sentences with phrase «specific immune response»

A variety of plant compounds, vitamins and minerals have been shown to decrease specific immune responses in the gut related to food sensitivity.

If melanoma cells can be made to produce IL - 2, this should stimulate a strong, specific immune response against them.

Although this problem can, to some extent, be addressed by the use of reporter constructs (e.g. Diptericin - LacZ) that provide quantitative or visual read - outs from specific immune response genes, we still lack the ability to follow bacterial infections in real - time in the critical early stages of infection.

Dr. Khleif's research interest is in identifying new and improved strategies to enhance specific immune response against cancer for preventive and therapeutic intent.

«Adenosine deaminase may help the immune system fight HIV on its own: Adenosine deaminase enhances anti-HIV-1 specific immune responses by reducing the action of cells that impede HIV - specific defenses.»

The functional activity of the herpesvirus - specific immune response decreases in elderly donors, although the characteristic phenotypes of CMV - and EBV - specific memory populations are retained.

They are referred to as serotypes 1 - 4 because, following infection, individuals have distinct antibody profiles in their blood serum, resulting from specific immune responses to each of the four virus types.

This «is believed to be the safest way to derive an Aß - specific immune response in someone with Alzheimer's,» says William Bowers, a University of Rochester neurologist who helped develop the vaccine.

Memory T - cells are the cells that become primed to mount a specific immune response when an antigen from a pathogen or injured tissue appears a second time.

Given the public health emergency that Zika virus poses, scientists are seeking to understand the Zika - specific immune response.

Dr. Gnjatic's research focuses on human antigen - specific immune responses to tumor antigens, in an attempt to define new targets for the development of cancer immunotherapies, assess the efficacy of these immunotherapies, and learn why they may fail.

Researchers then use these neoantigens to initiate a tumor - specific immune response.

Animals treated on day 3 following infection showed no evidence of virus in the blood and did not generate any SIV - specific immune responses.

However, the treatment did significantly reduce the severity of the asthma by counteracting one aspect of the specific immune response in the lungs.

Most importantly, many of the T cells were able to recognize the tumor cells directly, demonstrating that the vaccine had triggered a tumor - specific immune response that could target the patient's tumor.

Using transplantable tumor models expressing antigen in an inducible manner or spontaneous tumor models expressing nominal antigens, we try to decipher whether the tumor is ignored or leads to deletion, anergy or class switch of the specific immune response or generate suppressor T cells.

The Unit aims at studying and modulating antigen (Ag)- specific immune responses, to develop efficient therapeutic approaches to (re) establish Ag - specific immune tolerance in allogeneic bone marrow and solid organ transplantation, autoimmune diseases, allergy, and gene therapy.

«Vaccines, which work by boosting a specific immune response against an infectious agent, are one of the most effective public health interventions and have saved millions of lives.

The researchers report that the physician did not develop Ebola and showed Ebola - specific immune responses, but warn that questions about safety and efficacy of the vaccine can not be answered from a single case.

Lupus makes the immune system unable to differentiate between antigens (a substance capable of inducing a specific immune response) and healthy tissue.

«We can also potentially identify other small molecules or recombinant proteins to reduce this interleukin 2 receptor gamma activity in the body — even eye - specific immune responses — that might reduce cell rejection,» said Lamba.

Our AST - VAC immunotherapy programs employ three common elements of dendritic cells, telomerase antigen, and the LAMP signal sequence to stimulate robust and specific immune responses to cancer cells (Figure 1).

Recent studies show that this property can be exploited for the delivery of fused antigens into the major histocompatibility complex class I - restricted presentation pathway, with the goal of eliciting a specific immune response.

We hope to use data from RV144 to determine the specific immune responses the body needs to protect itself from HIV.

In CMV seropositive donors, the magnitude of the EBV - specific immune response is stable with age, but in CMV seronegative donors, the response to EBV increases significantly with age.

He and his colleagues have discovered that specific immune responses are indirect but sensitive measures of viral persistence and replication potential within HIV tissue reservoirs.

DNA sequences designed to either stimulate a specific immune response or to down - regulate an undesirable response deliver superior performance when organized on nanoparticles to reach their intended cellular targets.

If ablating the patient's autologous tumor can stimulate a tumor - specific immune response that persists after the tumor is removed, then creating an ally is what we would be doing.

We believe DCs are the most important immune cells to target because they initiate the specific immune response that generates CTLs to kill the tumor.

When introduced into the bladder, TICE BCG elicits a specific immune response that fights the tumor.

Allergens provoke a specific immune response, and make you vulnerable to infections which need a different type of response.

However, these should never be used — they have no scientific basis and can not provoke the specific immune response that is needed to provide protection.

The goal of this proposal is to build on our previous work developing a cell - based vaccine that aims to stimulate potent tumor - specific immune responses that will kill lymphoma cancer cells.

In the current study, Dr. Mason will optimize her cell - based vaccine approach to induce functional, long lasting tumor - specific immune responses that will prevent relapse and prolong survival in dogs with NHL.

A range of approaches to vaccine development could be supported, from attenuated bacteria (bacteria whose virulence has been reduced) to DNA vaccines (in which an animal is injected with genetically engineered DNA to produce a specific immune response).