For severe cases of atopic dermatitis that don't respond well to treatment, allergy injections, (called hyposensitization or allergen -
specific immunotherapy) are another — albeit more expensive — option.
Allergen -
specific Immunotherapy is the only allergy treatment that treats the cause of allergy, rather than merely manages the symptoms.
Specialized diagnostic and treatment services include: intradermal allergy testing and allergen -
specific immunotherapy, biopsy and dermatohistopathology, video otoscopy, myringotomy, and deep ear canal cleaning to name a few.
A review of allergen -
specific immunotherapy in human and veterinary medicine.
Intradermal allergy testing for dogs, cats, and horses is available to select allergen
specific immunotherapy unique for that patient's allergies.
Treatment could include allergy shots to desensitize your cat to the problem (allergen
specific immunotherapy), and the use of medications such as cyclosporin, glucocorticoids, antihistamines.
Allergen
Specific Immunotherapy: This involves giving an allergy vaccine injection that is made up specifically for your pet, usually for the lifetime of the animal.
Allergen -
specific immunotherapy involves injecting tiny amounts of the material causing your companion's reaction to create resistance to the substance.
Allergen -
specific immunotherapy makes dogs less sensitive to their allergens and 60 - 80 % of patients improve on immunotherapy.
Therapy for canine atopic dermatitis involves topical antipruritic therapies, parasiticides, antihistamines, fatty acids, glucocorticosteroids, allergen
specific immunotherapy and cyclosporin.
Other names for allergy injections include desensitization, hyposensitization, allergy vaccine, or allergen -
specific immunotherapy.
Cimetidine can alter skin testing for allergen
specific immunotherapy.
MVS offers advanced diagnostics and treatments such as intradermal (skin) allergy testing and formulation of allergen
specific immunotherapy.
Recent advancements have been made in sublingual versions of this allergen -
specific immunotherapy and trials appear promising.
Once the allergen (s) are known,
specific immunotherapy is used.
Appalachian Animal Clinic takes their treatment options one step further by offering allergen
specific immunotherapy.
«Sequential transcriptional changes dictate safe and effective antigen -
specific immunotherapy» [open access] by Bronwen R. Burton, Graham J. Britton, Hai Fang, Johan Verhagen, Ben Smithers Catherine A. Sabatos - Peyton, Laura J. Carney, Julian Gough, Stephan Strobel and David C. Wraith in Nature Communications.
Schulten V, Tripple V, Sidney J, Greenbaum J, Frazier A, Alam R, Broide D, Peters B, Sette A. Association between specific timothy grass antigens and changes in TH1 - and TH2 - cell responses following
specific immunotherapy.
Overview of melanoma vaccines: active
specific immunotherapy for melanoma patients.
It's hoped this latest insight will lead to the widespread use of antigen -
specific immunotherapy as a treatment for many autoimmune disorders, including multiple sclerosis (MS), type 1 diabetes, Graves» disease and systemic lupus erythematosus (SLE).
Professor David Wraith, who led the research, said: «Insight into the molecular basis of antigen -
specific immunotherapy opens up exciting new opportunities to enhance the selectivity of the approach while providing valuable markers with which to measure effective treatment.
Schumacher was the first to develop a technology for high - throughput analysis of immune cell reactivity to cancer neoantigens, which has allowed researchers to better observe the effects of immunotherapy in patients and has made it possible to develop personalized, patient -
specific immunotherapies.
Not exact matches
One
specific area of healthcare that has strong growth potential is
immunotherapy for cancer.
Our work suggests that targeting a
specific stem cell phenotype, for example with
immunotherapies, could be beneficial in patients with oligodendroglioma.»
Although Coley couldn't explain precisely why or how his toxins worked, modern
immunotherapy treatments help T - cells in the immune system to recognize
specific cancer cells and attack them.
Using advanced laboratory techniques, the scientists tracked changes in peanut -
specific T cells in five participants during the first 18 months of peanut
immunotherapy.
Immunotherapy caused an increase in peanut -
specific T cells, accompanied by a change in the distribution of T - cell subtypes over time.
In 2011, he established the Immunotherapeutics Clinical Core, a specialized phase 1 outpatient unit at MSK that is focused on the conduct of novel
immunotherapy trials, with a
specific emphasis on pharmacodynamic biomarker identification.
Dr. Gnjatic's research focuses on human antigen -
specific immune responses to tumor antigens, in an attempt to define new targets for the development of cancer
immunotherapies, assess the efficacy of these
immunotherapies, and learn why they may fail.
Therefore, «this finding may represent a future therapeutic strategic to combine with other strategies, such as
immunotherapy, chemotherapy or inhibitors against
specific signalling routes of the tumour cells.»
«Cancers evade
immunotherapy by «discarding the evidence» of tumor -
specific mutations: Discovery could explain widespread acquired resistance among patients treated with immune checkpoint blockade drugs.»
The researchers are collaborating with investigators at the University of Pennsylvania that have found that turning on a very
specific type of estrogen receptor on melanoma makes it vulnerable to
immunotherapy.
Currently, investigators around the world are experimenting with restoring the immune cells responsible for keeping CMV in check by transplanting those
specific anti-viral cells from healthy donors — a type of
immunotherapy.
In an accompanying editorial, Stanley Jordan, MD (Cedars - Sinai Medical Center) noted that if the findings are supported by additional studies, they could be of great help in counseling patients and possibly avoiding costly
immunotherapy to reduce what appear to be largely benign donor -
specific HLA antibodies.
While the finding does not directly lead to a test for
immunotherapy response yet, Choueiri said, «We intend to look at these
specific genomic alterations in larger, randomized controlled trials, and we hope that one day these findings will be the impetus for prospective clinical trials based on these alterations.»
Unlike active
immunotherapy with mimotopes, a passive
immunotherapy with
specific anti-tumour antigens has been clinically used for quite some time.
However, despite this success, the use of
immunotherapy remains limited by the scarcity of tumor -
specific antigens — substances that can trigger an immune system response to a particular type of cancer.
But the addition of rapamycin to
immunotherapy even for a short while also allowed the rodents to develop tumor -
specific memory CD8 + T cells that remember the
specific «signature» of the glioma tumor cells and attacked them swiftly when a tumor was introduced into the brain again.
«The next step is to perform preclinical studies with
specific inhibitors of HDAC11 alone and in tandem with other existing
immunotherapies, such as anti-PD1 / anti-PDL1 antibodies, in order to find the most potent combination.
Dr. June: It's been a very exciting time to see the change from the skepticism that we've all had to go through in the past, to now where there are
immunotherapies being FDA approved because they can activate cancer -
specific T cells.
Many tumours lack the
specific characteristics needed in order for the
immunotherapy to recognise and attack the cancer cells as enemies.
(PMID: 9545200) Dunbar PR, Chen JL, Chao D, Rust N, Teisserenc H, Ogg GS, Romero P, Weynants P, Cerundolo V. Cutting edge: rapid cloning of tumor -
specific CTL suitable for adoptive
immunotherapy of melanoma.
Tags: Acute Myeloid Leukemia, Andrew Hsieh, Basic Sciences, Clinical Research, Harmit Malik, Human Biology, Jesse Bloom, Marie Bleakley, Prostate Cancer, Transplant and
Immunotherapy, Tumor
specific translational research, Vaccine development - Viral cancers
Ana Cunha (Rieber, TUD)-- «Evaluation of D - TMPP for use in diagnosis and
specific cellular
immunotherapy of prostate cancer» (2007)
Coukos, who is currently leading an ovarian cancer clinical trial sponsored by CRI's Clinical Accelerator, sought to understand why PD - 1 / PD - L1
immunotherapies are often ineffective for these patients, even though ovarian tumors are often infiltrated by «killer» T cells that recognize tumor -
specific neoantigens and express high levels of PD - 1.
Through her CLIP Grant, she is analyzing patient samples to determine how Poly ICLC (a TLR agonist) affects the tumor environment and immune responses against
specific mutations, to identify how Poly ICLC could complement existing
immunotherapies.
CAR - T
immunotherapy involves genetically outfitting a patient's immune cells with a new artificial gene, a chimeric antigen receptor (CAR), which allows the cells to recognize and attack
specific cancer cells.
New treatments designed to direct the immune system against
specific cancer cells — called
immunotherapy — are also under study.
Researchers at Penn State found that melanoma patients who received
immunotherapy while taking a
specific type of beta blocker lived longer than patients who received
immunotherapy alone.
While mutational burden has important implications for treatment with
immunotherapy, the presence of
specific driver mutations is also of major therapeutic relevance (Table 3).