Sentences with phrase «specific ion channels»

Professor Asif Ahmed, Pro-Vice-Chancellor for Health and Professor of Vascular Biology at Aston University, said: «Our latest research highlights that compounds that deliver low levels of carbon monoxide can block specific ion channels in the heart muscle to allow the muscle time to contract properly and forcefully in a coordinated fashion.

For example, cardiologists would be delighted to have human cardiomyocytes in culture bearing mutations in specific ion channels.

Not exact matches

To avoid death, cells must remove fluoride that has accumulated inside them, a process accomplished via ion channels - protein tunnels through the cell membrane that only allow specific substances to pass through.

By placing lysine at specific locations, the voltage sensor can be stabilized in different conformations, which enables a dissection of voltage sensor movements and their relation to ion channel opening.

Ion channels are generally selective for certain ions, allowing specific types of ions to flow through at very high rates, while hindering the flow of others.

Ion channels are proteins found in a cell's membrane, which create tiny openings in the membrane that regulate the movement of specific ions.

For example, the identification of highly specific and potent CFTR inhibitors has led to a number of studies examining the role of CFTR ion channel function in basic physiological processes.

Among the most interesting ones identified were those associated with 1) the large category of transport, and the more specific categories of carbohydrate transport and cation: amino acid symport; 2) several related to calcium, including calcium ion binding, calmodulin binding, and voltage gated calcium channel activity; 3) DNA damage response and signal transduction; 4) response to oxidative stress; and 5) oxygen and reactive oxygen species metabolism.

Future therapies will have to be based on strategies that act by reducing or increasing the number or activity of specific subtypes of pre - and postsynaptic receptors, transporters, and ion channels, or other membrane molecules at the synapse, and by strategies that exploit the new possibilities offered by stem cell technology and targeted repair.

In the case of the modified fruit fly, when infrared light impinges on a specific region, the temperature at this point is raised to 30 Celsius from ambient temperature, which alters the engineered thermo - sensitive ion channels and so infrared light.

These broad associations with complexity are evidently superimposed on notable lineage - specific variation as seen in Fig. 4 (for example, serine protease gene loss in C. elegans, and voltage-gated ion channel expansion in Paramecium).

Amiodarone is known to specifically block ion channels, which suggests that the effect seen in the drug treated samples is specific to amiodarone HCL activity.

To elucidate functional roles of specific neuronal populations, signaling mechanisms and ion channel types, in active neuronal networks, and in the brain of behaving animals.

Cell type - specific pharmacology for activating genetically engineered ion channels has been described (Slimko et al., 2002; Magnus et al., 2011), and here we demonstrate rapid cell type - specific blockade of a native ion channel with a small molecule.