Sentences with phrase «specific isoform»

We thus confirmed that the predominant expression of Boule during reproductive development is in the adult testis, including a testis - specific isoform, and also identified previously unreported low levels of Boule RNA in mouse ovaries.

Pancreatic cyst fluid is tested for a biomarker, a specific isoform of vascular endothelial growth factor A, or VEGF - A.

Oocytes contain a high concentration of an oocyte - specific isoform of p63 which plays a key role as a quality control factor in causing infertility.

The demand for splicing is high in retinal cells, which have lots of tissue - specific isoforms.

The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL - 6 corepressor.

Not exact matches

In those cells the Esrp1 and Esrp2 proteins enforce epithelial - specific splicing isoforms for hundreds of different genes, as Carstens and his team have shown in studies since 2009.

We are one of the most referenced companies in the industry and continue to collaborate to develop products such as isoform - specific AKT antibodies, green fluorescent protein (GFP) and red fluorescent protein (RFP) antibodies, and fluorochrome - conjugated secondary antibodies.

Although the current study demonstrates that loss of IL - 15Rα promotes this phenotype, future studies are needed to determine the roles of specific IL - 15Rα isoforms in muscle, as well as the associations of additional IL15RA polymorphisms in muscle phenotypes in humans.

Buy human recombinant laminins from BioLamina - culture stem cells, differentiate to neurons, RPE cells, cardiomyocytes and other cells on their specific laminin isoform.

Laminin - 521 induce fast migration of the cells and laminin isoform specific activation of PI3K / Akt pathway through interaction with α6β1 integrin.

Isoform - Specific PKA Dynamics Revealed by Dye - Triggered Aggregation and DAKAP1 [alpha]- Mediated Localization in Living Cells.

Here we use a chemical genetics approach using knock - in mice in which either p38alpha or p38beta kinase has been rendered resistant to the effects of specific inhibitors along with p38beta knock - out mice to dissect the biological function of these specific kinase isoforms.

Thus, although NMHC II - A can substitute for NMHC II - B to maintain integrity of the spinal canal, NMHC II - B plays an isoform - specific role during cytokinesis in cardiac myocytes and in migration of the facial and pontine neurons.

More than half of mammalian genes generate multiple messenger RNA isoforms that differ in their 3 ′ untranslated regions (3 ′ UTRs) and therefore in regulatory sequences, often associated with cell proliferation and cancer; however, the mechanisms coordinating alternative 3 ′ - UTR processing for specific mRNA populations remain poorly defined.

There are a total of 12 possible isoforms, which are distributed in the human body in a tissue - specific manner.

Wong, H., Levenga, J., Cain, P., Rothermel, B., Klann, E., and Hoeffer, C. (2015) Isoform - specific RCAN1 overxpression promotes age - dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer's disease.

ESRP1 is central to intestinal barrier integrity in mice and humans and alterations in ESRP1 function or expression contribute to intestinal pathology, partly through modified expression of ESRP1 - specific GPR137 isoforms.