Sentences with phrase «specific killer cells»

Other immune cells, the specific killer cells, which are also known as CD8 + T cells and multiply prodigiously and mature in response to an infection, can also exhibit stress symptoms and thereby potentially end up on the NK cells» hit list.

Not exact matches

Chronic HIV infection results in exhaustion of the immune system, a phenomenon characterized by dysfunctional HIV - specific killer T cells.

In the women about one in 68,000 killer T cells were specific for H - Y.

A bigger surprise came when the scientists surveyed the blood samples for killer T cells specific to other foreign peptides.

That meant a sizeable number of their H - Y - specific killer T cells had escaped deletion.

Results showed that antibodies were able to bind to the cancer cells and recruited specific immune cells called natural killer cells, resulting in shrinkage of the tumor, significantly improving survival.

Here, we show that in germ - free (GF) mice, invariant natural killer T (iNKT) cells accumulate in the colonic lamina propria and lung, resulting in increased morbidity in models of IBD and allergic asthma as compared with that of specific pathogen - free mice.

Vincenzo Cerundolo and colleagues demonstrate that co-injection of invariant natural killer T (iNKT) cell agonists together with antigenic proteins enhances antigen - specific CD4 and CD8 T cell responses.

Without this specific region in Foxp3, Treg cells are much more likely to lose their identity and defect into killer T cells when faced with inflammation and infection, says Zheng.

Coukos, who is currently leading an ovarian cancer clinical trial sponsored by CRI's Clinical Accelerator, sought to understand why PD - 1 / PD - L1 immunotherapies are often ineffective for these patients, even though ovarian tumors are often infiltrated by «killer» T cells that recognize tumor - specific neoantigens and express high levels of PD - 1.

CAR - T cells are human killer T cells artificially engineered to target specific proteins (antigens) associated with a cancer.

Previous research from the laboratory of Dan S. Kaufman at the Stem Cell Institute, University of Minnesota, USA has demonstrated that large numbers of Natural Killer (NK) immune cells with potent anti-HIV activity [1] can be derived from hESCs and iPSCs [2, 3], although they lack antigen specific recognition receptors [4, 5].

They do, however, play a key role in helping to boost the anti-tumor immune response by: (1) expanding the number and improving the function of existing CTLs that are specific to the same tumor antigen; and (2) providing help to other immune cells, including B lymphocytes that are precursors to antibodies and natural killer (NK) cells that are also important in the overall anti-tumor immune response.

Natural killer (NK) cells, the «rapid response» cells of the innate immune system, can kill virally infected cells and thereby slow down an infection until antigen - specific and clonally - expanded cytotoxic T cells can be recruited to finish the job.

We demonstrate a novel outcome of S1P - mediated regulation of lymphocyte trafficking, whereby deletion of Spns2, either globally or in a lymphatic endothelial - specific manner, creates a circulating lymphopenia and a higher percentage of effector T cells and natural killer (NK) cells present in the lung.

by specific direct stimulation of immune system's Natural Killer Cells.

Shinrin - yoku trails in Japan are only certified as such after blood sampling shows a specific increase in natural killer cells.

These immune cells that include macrophages, dendritic cells, and natural killer cells, directly attack invading microbes by various means depending on their specific function.