Sentences with phrase «specific laboratory models»
Realistic stem cell therapies to replace diseased or damaged tissue may still be years away, but researchers have uncovered a promising new use for these undifferentiated cells: they can be programmed to become patient - specific laboratory models of inherited liver disease.
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A study combining tumor cells from patients with breast cancer with a laboratory model of blood vessel lining provides the most compelling evidence so far that a specific trio of cells is required for the spread of breast cancer.
In a previous study, investigators at the Cancer Institute showed that using a vaccine treatment for bladder and breast cancer tumors in laboratory models resulted in a reversal of the traditional immune blockade, as well as the development of tumor specific immunity throughout the body.
This unique research model brings together four laboratories, each with a specific skill, to work together to discover new biomarkers.
«Originally, we wanted to establish a disease model for FOP that might help us understand how specific gene mutations affect bone formation,» said first author Yohei Hayashi, PhD, a former postdoctoral scholar in Yamanaka's laboratory.
«Originally, we wanted to establish a disease model for FOP that might help us understand how specific gene mutations affect bone formation,» said first author Yohei Hayashi, PhD, a former postdoctoral scholar with Yamanaka's laboratory.
Previously, he worked in the laboratories of Dr. Paul Greengard and Dr. Myriam Heiman, utilizing similar cutting - edge cell - type specific techniques to investigate pathology of Huntington's disease model in mice.
Dr. Jason Yustein's research laboratory is utilizing tissue - specific expression of an oncogenic p53 mutant to form novel, applicable transgenic mouse models of metastatic osteosarcoma and rhabdomyosarcoma, both conditions that have particularly poor patient outcmes.
Making use of cell and animal models, my laboratory group addresses some of the fundamental questions of how ethanol exposure injures the liver, with a goal ofidentifying the individual targets of ethanol - induced injury and the specific responses of the key cell types within the liver, as well as the integrated, organismal response to this ethanol - induced injury.