Sentences with phrase «specific lipid»

Entry of Bluetongue Virus Capsid Requires the Late Endosome - specific Lipid Lysobisphosphatidic Acid.

Strikingly, no perilipin othologue has been identified in C. elegans, suggesting that nematode - specific lipid regulatory pathways might exist in this phylum and perhaps in others as well.

Because the two species have had about the same amount of time to rack up changes to their lipid profiles, the investigators expected them to have roughly the same number of species - specific lipid concentrations, explains computational biologist and study leader Kasia Bozek of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany.

Thus, distribution and mobility of specific lipid species at the plasma membrane appears to precisely regulated by membrane - associated proteins.

It's possible that emerging virus particles display nerve - specific lipid compounds.

Mainak Dutta and colleagues wanted to find out whether endometriosis has a specific lipid profile that might lead to a less invasive diagnostic test.

Future studies that follow dogs long term and look at specific lipid content in the blood may shed light on the mechanisms behind cholesterol's role in enhanced survival, Leeper said.

The importance of this issue is clear: it has the potential to provide new insights into the pathogenesis of T2D and has implications for the effect of specific lipid - altering therapies on the development of T2D.»

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

Using samples from the Dominantly Inherited Alzheimer Network (DIAN) study, the researchers found that people who carried the mutation responsible for this form of Alzheimer's also had altered levels of specific lipids in their blood plasma compared to the control group.

But on what specific lipids do these newly discovered outlier enzymes normally work?

These enzymes flip specific lipids between the inner and outer layers of the membrane.

Our strong expertise allows us study lipid - protein interaction based phenomena at different scales, from the organ and cellular systems down to minimal synthetic systems in which we can control the proteins as well as the lipid, for instance to monitor the allosteric effects of specific lipids on fundamental receptors such as the EGF receptor (Coskun et al (2011) PNAS) and the insulin receptor.

She is also using lipidomicsas another approach to inquire in an unbiased manner whether specific lipids are changed in HD.

The high levels of specific lipids such as pucinic acid that counter inflammation and reduce swelling.

Not exact matches

They are also designed to meet the nutritional needs of children: high energy input, high protein and essential amino acid requirements, specific requirements for vitamins, minerals, macro and micronutrients, appropriate lipid content and little salt.

Stage - specific transcripts are associated with immune defense during the colostral stage, up - regulation of the machinery needed for milk protein synthesis during the transitional stage, and the production of lipids during mature lactation.

«Specific bacteria in the small intestine are crucial for fat absorption: A high - fat diet promotes growth of the microbes that boost lipid digestion and absorption.»

«Although further studies are needed to examine whether specific pathways or lipid subtypes are implicated, our findings inform potential expected downstream consequences of interventions affecting lipid traits and provide cautionary evidence that therapeutics that lower LDL - C and TG levels may have dysglycemic [abnormal blood sugar levels] effects,» the authors write.

«If we fed the fish a specific type of fat, our technique allowed us to determine into what molecules these lipids were reassembled after they were broken down in the small intestine and in which organs and cells these molecules ended up,» Farber explained.

The research team, led by Robert Stahelin of Purdue University, found the specific parts of VP40 that bind with the lipid: a cationic patch on the end of an amino acid chain.

Comparative analyses of the range of fatty acids and lipids present in the infected roots of the wild - type and mutant hosts revealed that certain fungus - specific fatty acids are either missing or their levels are drastically reduced in the colonized roots of mutant L. japonicus strains.

That is, when compounds intended to influence a specific protein target also alter lipid bilayer properties, they may alter the function of numerous membrane proteins and thereby cause a cascade of usually unwanted off - target and side effects.

By varying the compositions of lipids, cues, and diffusible factors in the scaffolds, we engineered a very versatile and flexible platform that can be used to amplify specific T cell populations from blood samples, and that could be deployed in existing therapies such as CAR - T cell therapies,» said Mooney, Ph.D., a Core Faculty member at the Wyss Institute and leader of its Immunomaterials Platform.

Biology at the subcellular level can be likened to a dance: Proteins, lipids, sugars and other molecules follow specific steps to sustain the energy needs, respiration and reproduction of life.

«The finding that certain cell signaling lipids change the activity of an oncogenic Ras protein, suggests that we might be able to interfere with tumor progression by inhibiting the enzymes which make the specific cell signaling lipid in cells,» Buck said.

They traced the effect to increased production of a specific type of lipid that, surprisingly, prevented the formation of aggregate proteins.

But now a new study led by the lab Kristina Schoonjans at EPFL, suggests that a specific group of bile acids could directly burn away the lipids in our fat depots, effectively making it a new therapy against obesity.

The membranes of the cells in our bodies are only approximately 4 to 5 nanometers thick and consist of a complex mixture of lipids and specific membrane proteins, which also include channel proteins.

As a result, blocking FASN increases the amounts of a specific type of lipids in mitochondria, reducing the degradation of neurons.»

«RNAi therapies are a unique approach to cancer treatment as they have the potential to «turn off» the genes» coding for proteins involved in cancer cell division,» said Ramesh K. Ramanathan, M.D., medical director of the Virginia G. Piper Cancer Center Clinical Trials Program at Scottsdale Healthcare and deputy director of the Clinical Translational Research Division of the Translational Genomics Research Institute (TGen) in Phoenix, Ariz. «Using a lipid nanoparticle, the RNAi drug can be delivered to a cancer cell to block the expression of specific proteins involved in tumor growth.»

The CARS systems allow visualization of lipids of specific categories by tuning into symmetric CH2 vibrations of specific fat composing molecules (Zumbusch, Langbein & Borri, 2013).

Synthesized from a combination of modified versions of the amino acid glycine, the new film is flexible, allows greater control over desired interactions through introduction of specific side chains, and is far more thermally and chemically stable than those assembled from natural polypeptides or lipids.

He developed an innovative microdialysis approach that allows the in vivo sampling of lipid signaling molecules in the brain (including endocannabinoids) and has demonstrated that voluntary self - administration of ethanol, heroin, and cocaine produces distinct drug - and region - specific changes in brain endocannabinoid levels.

Moreover, the new comprehensive dataset describing lipid accumulation in Y. lipolytica will enable more detailed experiments to provide specific genetic targets for future metabolic engineering efforts.

Genes involved in lipid metabolism and glycolysis were associated with female - specific genes, whereas hepatic metabolism, detoxification, and secretion were associated with male - specific genes.

Even though transient and weak it is becoming more and more obvious that lipid protein interactions are the key for many regulatory processes in which specific protein complexes have to be formed for example upon stimuli during cell signaling.

Endocrine disruptors mostly travel with lipids and accumulate in adipocytes causing reactive changes in adipokine levels, which happen in a sex - and disruptor - specific way.

Based on these observations, sex - specific body shape and lipid accumulation could already be determined in utero, especially in insulin sensitive locations varying by fetal sex.

S1P is a signaling lipid mediator, which is generated inside the cells by sphingosine kinases, exported out of the cells, then bind and signal through five S1P specific G - protein coupled receptors (S1PR1 - 5), coined «inside - out signaling» (Takabe K et al, Pharmacological Reviews 2008, Takabe K et al, Journal of Lipid Research 2lipid mediator, which is generated inside the cells by sphingosine kinases, exported out of the cells, then bind and signal through five S1P specific G - protein coupled receptors (S1PR1 - 5), coined «inside - out signaling» (Takabe K et al, Pharmacological Reviews 2008, Takabe K et al, Journal of Lipid Research 2Lipid Research 2014).

While our work is already showing that combinations of genetics, specific neuronal proteins, lipids and inflammation are key factors in neurodegenerative diseases, much more work is needed.

The report, published online in the Proceedings of the National Academy of Sciences, suggests that it may be possible to prevent the vision loss observed in wet AMD by increasing the expression of specific bioactive lipid metabolites in the retina.

A study in the Journal of Lipid Research looks at the life stages of a microorganism that causes a blinding eye infection, aiming to find a target for a species - specific drug.

Tim has also used remote homology tools to identify a new family of lipid transfer proteins anchored at contact sites, and highlighted the power of these tools through specific examples and a «How - To» guide.

Antigen - specific enhancement of natural human IgG antibodies to phosphatidylcholine, phosphatidylglycerol, phosphatidylinositol -4-phosphate, cholesterol, and lipid A by a liposomal vaccine Containing lipid A.Vaccine.

This result indicates that FatM and RAM2 may play specific roles in the biosynthesis of 16:0 βMAG, and further highlights the importance of this particular lipid for AM symbiosis.

For lipid visualization, a lipid - specific stain boron - dipyrromethene (BODIPY 493/503; Invitrogen D - 3922) was used.

Numerous studies have linked cases of specific cancers, heart attacks and increased lipid levels to improper use of supposedly «safe» dietary supplements, such as Vitamins, A, D, E and K and calcium.

Beyond needing a small amount of very specific fats, our body is capable of synthesizing its own lipids (saturated fat, n9 fatty acids, and cholesterol, to name a few).

Those proteins will often be anchored in specific regions called «lipid rafts,» which are enriched in saturated fatty acids to provide the stability needed to keep those proteins from floating away from their proper position.