Sentences with phrase «specific lymphocytes»

Hands - on experience with isolating, culturing, and expanding antigen - specific lymphocytes from human whole blood

Charles Janeway introduces the hypothesis that «components of the innate [immune] system, especially antigen - presenting cells such as DCs, required the microbial stimuli contained in [adjuvants] to become activated and acquire the capacity to induce productive responses from antigen - specific lymphocytes.

The immune responses will be evaluated in the different species by measuring influenza antigen - specific IgG / IgA and IgM, neutralising antibodies and antibodies inhibiting hemagglutination and antigen specific lymphocyte responses and cytokine secretion profiles by advanced flow cytometry.

Antigen specific lymphocyte responses and cytokine secretion profiles will be assessed by advanced flow cytometry.

Unlike NHL, which has many different subtypes, Hodgkin lymphoma is mostly distinguished by the presence of what's called Reed - Sternberg cells, or abnormal types of a specific lymphocyte.

These findings are also in line with other studies that have shown that chronic caregiver stress in the postpartum and early childhood period has been associated with persistent wheeze in early childhood4 as well as factors that may initiate or potentiate inflammation in the lung (eg, IgE expression, enhanced nonspecific and allergen - specific lymphocyte proliferation, differential cytokine expression).5, 7 Both persistent wheeze and atopy have been linked to reduced lung function in childhood.49 This cumulative stress model is particularly relevant given that maternal IPV may become a more direct stressor for toddlers who are witnessing violence against their mothers.50

Not exact matches

«Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages»

The team says their method could be applied to lymphocytes taken from bipolar patients» blood samples, to find out whether specific individuals would be good candidates for lithium therapy.

By characterizing memory lymphocytes from ZIKV - infected patients, we dissected ZIKV - specific and DENV — cross-reactive immune responses.

«That protection was probably caused by specific T - lymphocytes and antibody responses to the parasites in the liver,» Professor Peter Kremsner explained.

Thus, this cDNA derives from a gene (oct - 2) that specifies an octamer binding protein expressed preferentially in B lymphocytes, proving that, for at least one gene, a cell - specific transcription factor exists and its amount is controlled through messenger RNA availability.

LPA in turn acts on lymphocytes via a specific receptor (LPA2), enabling them to move around efficiently through the narrow spaces in lymph nodes, which are normally jammed with immune cells and stromal cells.

A new technique of direct binding of radioactive DNA was used to screen a complementary DNA expression library from the BJAB cell line in lambda gt11 phage to derive molecular cDNA clones representing a putative B lymphocyte - specific octamer binding protein.

LPA is produced by a specific type of stromal cells, which forms a scaffold for lymphocytes to crawl around within the node.

Depletion of neutrophils blocks the recruitment of antigen non-specific cells into the liver without affecting the antiviral activity of hepatitis B virus - specific cytotoxic T lymphocytes.

Adaptive immune responses are initiated by the clonal selection of naive T lymphocytes, which recognize their cognate ligands through antigen - specific T cell receptors.

Pierre Coulie and Thierry Boon, [i] and Thomas Wölfel [ii] show that human T lymphocytes recognize antigens caused by driver278 or passenger279 tumor - specific mutations.

[i] Romero P, Dunbar PR, Valmori D, Pittet M, Ogg GS, Rimoldi D, Chen JL, Lienard D, Cerottini JC, Cerundolo V. Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen - experienced tumor - specific cytolytic T lymphocytes.

Blocking chemokine responsive to -LCB- gamma -RCB--- 2 / interferon (IFN)- -LCB- gamma -RCB- inducible protein and monokine induced by IFN --LCB- gamma -RCB- activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus — specific cytotoxic T lymphocytes.

Improved proliferation of antigen - specific cytolytic T lymphocytes using a multimodal nanovaccine.

Hsiou - Chi Liou and colleagues find that c - Rel, a lymphoid - specific member of the NF - kappaB / Rel family of transcriptional factors, is essential for B lymphocyte survival and cell cycle progression, [i] and that it is important for inducible cytokine and cytokine receptor expression and a key regulator of early activation and proliferation in T cells.

The iPSCs eventually turned into fully active, cancer - specific T - lymphocytes - in other words, cells that target and destroy cancer cells.

However, lymphocytes isolated from recipients of either CD8 + T cells or CD8 − T cells produced significant in vitro apoptosis of donor - specific corneal endothelial cells.

In our laboratory we had the idea of localizing on tumor cells, with specific monoclonal antibodies, molecules, such as Major Histocompatibility Complexe (MHC), loaded with viral peptides, which can activate the T lymphocytes to attack the target tumor cells.

If sufficient 1,25 - dihydroxyvitamin D is produced, it may exert paracrine effects on surrounding T lymphocytes, thereby regulating the tissue - specific immune responses.10 Some support for this hypothesis comes from recent experiments showing that mice fed diets high in vitamin D had significantly fewer clinical and pathological signs of EAE than mice fed a vitamin D — deficient diet.37 Central nervous system levels of 1,25 - dihydroxyvitamin D, but not blood levels, were higher in supplemented mice than in vitamin D — deficient mice and correlated inversely with disease severity.

Hiroshi Kawamoto and team created cancer - specific killer T - lymphocytes from iPSCs.

This project will determine whether specific populations of lymphocytes are required for RGC death in glaucoma.

They started off with mature T - lymphocytes which were specific for a type of skin cancer and reprogrammed them into iPSCs with the help of «Yamanaka factors».

The laboratory of Vincenzo Cerundolo is the first group to report the use of tetrameric soluble class I / peptide complexes (tetramers) for the identification of tumor - specific cytotoxic T lymphocytes (CTLs), and subsequently shows that these novel reagents allow rapid and accurate analysis of human CTL responses.

(PMID: 9802976) Download PDF [ii] Ogg GS, Rod Dunbar P, Romero P, Chen JL, Cerundolo V. High frequency of skin - homing melanocyte - specific cytotoxic T lymphocytes in autoimmune vitiligo.

Depletion of neutrophils blocks the recruitment of antigen - nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus - specific cytotoxic T lymphocytes.

Gamze Gunal (Jessberger, TUD)-- «Stage - specific binding profile of cohesin in resting and switch - activated B lymphocytes» (2013)

The main mechanism includes phagocytosis of macrophages which play a critical role in nonspecific defense (innate immunity) and, moreover; they have a role as antigen presenters which also help initiate specific defense mechanisms (adaptive immunity) by recruiting other immune cells such as lymphocytes.

Once the body recognizes an invader, lymphocytes produce antibodies, special chemicals tailored to fight a specific kind of invading microbe or material.

These approaches are designed to generate strong, tumor - specific cytotoxic T lymphocytes (CTLs) and attempt to overcome shortcomings of other approaches.

ILCs are a broad class of lymphocytes that lack diverse, rearranged antigen - specific receptors [9, 10].

We hypothesize that both the quality and timing of DENV - specific antibody and T lymphocyte responses influence whether their overall effect is beneficial (controlling DENV replication and reducing the severity of illness) or harmful (creating a «cytokine storm» leading to plasma leakage).

Accumulation of MCMV - specific CD8 + T lymphocytes was seen in all organs tested and was associated with continuous activation of specific CD8 + T lymphocytes, primarily within lymph nodes.

These groups of B lymphocytes produce antibodies specially designed to fight the specific invader or turn into antibody - secreting cells and memory B cells that give long - term protection and help protect the next time the same pathogen is encountered.

They do, however, play a key role in helping to boost the anti-tumor immune response by: (1) expanding the number and improving the function of existing CTLs that are specific to the same tumor antigen; and (2) providing help to other immune cells, including B lymphocytes that are precursors to antibodies and natural killer (NK) cells that are also important in the overall anti-tumor immune response.

Stage - specific binding profiles of cohesin in resting and activated B lymphocytes suggest a role for cohesin in immunoglobulin class switching and maturation.

We demonstrate a novel outcome of S1P - mediated regulation of lymphocyte trafficking, whereby deletion of Spns2, either globally or in a lymphatic endothelial - specific manner, creates a circulating lymphopenia and a higher percentage of effector T cells and natural killer (NK) cells present in the lung.

Non-Hodgkin lymphoma — sometimes also called non-Hodgkin's lymphoma or just NHL — covers a number of different cancers that start in a specific type of white blood cells called lymphocytes.

T - 11 cell lymphocytes supply a fundamental antibody capability to keep the specific defense system strong.

These cells, along with dendritic cells, recognize the incoming undigested food particles, toxic agents, and bacterial components as foreign invaders, and present them to cells of the adaptive immune system called T and B lymphocytes, leading to clonal expansion (proliferation or multiplication of specific subsets of T and B cells) and recruitment of more pro-inflammatory immune cells to the gut through a process called leukocyte homing.

Glutamine is an important fuel for some immune cells, such as lymphocytes and macrophages, that may have specific immunostimulatory effects.24, 25

Abnormalities that are commonly seen in Cushing's patients are: Elevated liver enzymes (Alk Phos, + / - ALT), + / - increased blood glucose, unconcentrated urine (specific gravity less that 1.025), protein in urine, Alterations in blood cell counts (increased neutrophils, decreased lymphocytes and eosinophils), and + / - nucleated red blood cells.

It prevents a certain specific group of lymphocytes (immune system cells) the helper T - lymphocytes, from transmitting chemical messages (calcineurin / interleukins) that result in histamine release from your dog's skin mast cells.

Pet lymphoma originates in cells known as lymphocytes, which are a specific type of white blood cell of the immune system.

When lymphocytes and plasma cells are the predominant cell types the most likely underlying causes are sensitivities to dietary components (wheat gluten is one example), parasites, bacterial toxins, cancers, heritable tendencies (occurs in Basenjis and wheaten terriers), and again a big group of dogs where a specific underlying cause isn't identifiable, or the idiopathic cases.