Sentences with phrase «specific marker in»

By using immunoprecipitation and mass spectrometry, we identified autoantibodies anti-Adenylate kinase 5 (AK5 - Abs) as specific marker in 10 patients with LE.

The expression patterns of cell class - specific markers in mosaic retinas appeared the same in host and donor derived regions suggesting that donor cells generated all retinal cell classes in approximately normal ratios (Figures 5K — 5N and S2).

Not exact matches

For one, it would give them three specific biological markers to hone in on: The buildup of beta amyloid and tau proteins, which cause brain plaques associated with Alzheimer's, and brain nerve cell death.

Zoom in to see all of the schools in a specific area and click on the marker to find out more information about the school.

In a description of a sleep disorder known as RBD, in which patients enact their dreams through movement, he notes that a deficiency of dopamine (a specific brain neurotransmitter) is one key marker of Parkinson's diseasIn a description of a sleep disorder known as RBD, in which patients enact their dreams through movement, he notes that a deficiency of dopamine (a specific brain neurotransmitter) is one key marker of Parkinson's diseasin which patients enact their dreams through movement, he notes that a deficiency of dopamine (a specific brain neurotransmitter) is one key marker of Parkinson's disease.

On this usage, if undifferentiated societies fight wars, religion is in fact involved in those wars precisely as a marker of societal identity, whether specific references to beliefs are invoked or not.

This latest study builds on Dr Sathe's previous work in developing a bank of marker proteins for a variety of nuts, although that research did not allow for investigation of specific nut allergens.

Some teams use zonal and have specific man marker for a dangerous player... shearer, Carroll etc who did or can excel at putting the ball in the back of the net from a corner.

Not only is the sample size bigger than Hamer's, but there are now far more genetic markers available, allowing Sanders to zero in on specific genes much faster.

The company wanted to use it as a diagnostic marker for disease: If synthetic versions of antibodies could be tagged with aequorin in the lab, then whenever they matched up with an antigen (or surface protein) of a specific pathogen in blood or tissue, the sample would glow.

Abiraterone's ability to lower levels of prostate - specific antigen, a surrogate marker for prostate cancer, was slightly greater for patients in the low - dose with food group when measured at 12 weeks.

In contrast, mitochondrial DNA (mtDNA) markers tend to mutate more slowly than microsatellites, often including variation specific to a particular species rather than an individual or population.

But in May, the U.S. Food and Drug Administration for the first time allowed the use of an existing approved drug, Keytruda, to treat any solid tumor bearing a specific genetic marker.

The analysis checked the tissue samples for specific genetic markers found in brown or beige fat.

Eggen and his collaborators investigated the impact of high - and low - fat diets on inflammation and microglial markers in a specific brain region — the hypothalamus — of 6 - month - old mice.

University Professor of Applied Physics Stephen Arnold and his team at the New York University Tandon School of Engineering have made a discovery that could lead to Star Trek - like biosensor devices capable of flagging the barest presence in blood of a specific virus or antibody, or protein marker for a specific cancer; or sniffing out airborne chemical warfare agents while they are still far below toxic levels.

«One can imagine that a SLIM - based tissue imager will scan biopsies in a clinic and, paired with software that is intelligent enough to look for these specific markers, will provide the pathologist with valuable new information.

«Our findings show that a specific genetic marker (known as allele * 2 of the HS1, 2 A enhancer region) influences not just disease activity in RA patients, but also response to therapy in the early stages of their disease,» said lead investigator Dr Gabriele Di Sante of the Institute of Rheumatology and Related Sciences, Catholic University of the Sacred Heart, Rome, Italy.

The results showed that, when applied, a long - term inhibition of Rho - kinase signaling increased the expressions of chondrocyte - specific genes and differentiation markers in human chondrosarcoma 2/8 cells.

A specific genetic marker influences response to therapy in the early stages of RA; a link thought to be due to the gene activating a cell - signalling protein involved in the inflammatory disease process.

The Australian researchers isolated a specific DNA marker for femininity in the lizard before exposing three additional clutches of eggs to varying temperatures.

The tumour has completely disappeared in the two patients after three to four treatments and can no longer be detected neither by PET / CT imaging nor by the tumour marker PSA (Prostate - specific antigen), whose blood level is often elevated in men with prostate cancer.

The use of cell surface markers to isolate specific cell populations is one common method for separating cells; however, isolating live cells based on their RNA expression is a powerful new way enabling the study of small cell niches in nongenetically modified animal models and human tissue.

By analyzing genetic markers specific to sweet potatoes in both modern samples of the plant and older herbarium specimens, the researchers discovered significant differences between varieties found in the western Pacific versus the eastern Pacific.

Next steps for the team include identifying microbiota metabolites whose levels are either significantly elevated or depleted during diseases such as IBD or cancer, to find disease - specific markers and explore possible roles for these metabolites in disease progression.

Researchers at Karolinska Institutet have identified cell surface markers specific for the very earliest stem cells in the human embryo.

A newly published International Osteoporosis Foundation (IOF) and European Calcified Tissue Society (ECTS) Working Group position paper [1] proposes measuring specific bone turnover markers (BTMs) in patients who have initiated use of oral bisphosphonates for postmenopausal osteoporosis as a clinically feasible and practical way to identify low adherence.

To target the virus to GABAergic neurons, the researchers used a genetically engineered mouse line that expresses a marker protein in these specific neurons only.

The cancer cell marker that Johnson and her team identified was a specific change in protein glycosylation, that is, a unique pattern of sugars decorating a protein found on the cell surface.

For the first time, researchers report identifying a biological marker: the over-production of specific genes that could be a diagnostic indicator of mental illness in female psychiatric patients.

In a paper published in the journal Nanotechnology [«Static micro-array isolation, dynamic time series classification, capture and enumeration of spiked breast cancer cells in blood: the nanotube - CTC chip»], Panchapakesan's team, which includes graduate students Farhad Khosravi, the paper's lead author, and researchers at the University of Louisville and Thomas Jefferson University, describe a study in which antibodies specific for two markers of metastatic breast cancer, EpCam and Her2, were attached to the carbon nanotubes in the chiIn a paper published in the journal Nanotechnology [«Static micro-array isolation, dynamic time series classification, capture and enumeration of spiked breast cancer cells in blood: the nanotube - CTC chip»], Panchapakesan's team, which includes graduate students Farhad Khosravi, the paper's lead author, and researchers at the University of Louisville and Thomas Jefferson University, describe a study in which antibodies specific for two markers of metastatic breast cancer, EpCam and Her2, were attached to the carbon nanotubes in the chiin the journal Nanotechnology [«Static micro-array isolation, dynamic time series classification, capture and enumeration of spiked breast cancer cells in blood: the nanotube - CTC chip»], Panchapakesan's team, which includes graduate students Farhad Khosravi, the paper's lead author, and researchers at the University of Louisville and Thomas Jefferson University, describe a study in which antibodies specific for two markers of metastatic breast cancer, EpCam and Her2, were attached to the carbon nanotubes in the chiin blood: the nanotube - CTC chip»], Panchapakesan's team, which includes graduate students Farhad Khosravi, the paper's lead author, and researchers at the University of Louisville and Thomas Jefferson University, describe a study in which antibodies specific for two markers of metastatic breast cancer, EpCam and Her2, were attached to the carbon nanotubes in the chiin which antibodies specific for two markers of metastatic breast cancer, EpCam and Her2, were attached to the carbon nanotubes in the chiin the chip.

The circuit, which will only activate a therapeutic response when it detects two specific cancer markers, is described in a paper published in the journal Cell.

Similarly, disease - specific fluorescence markers are finding their way back into basic research in high content screening applications.

These cells also showed early markers that are specific to developing Purkinje cells, granule cells, or deep cerebellar projection neurons — all types of neurons only found in the cerebellum.

A short - term inhibition of Rho - kinase failed to induce extracellular matrix production in fibroblasts or in HCS - 2 / 8 cells, while its long - term exposure increased the expressions of chondrocyte - specific genes and differentiation markers, and also promoted the synthesis of sulfated glycosaminoglycans by chondrocytic cells.

Median mouse - specific IgE levels — an immune system allergy marker — were 13 and 10 kilounits per liter in the IPM plus education and education only groups, respectively.

Pluripotent cells were cultured in mouse Noggin protein for 5 d and immunocytochemistry was used to detect retinal specific markers.

Discovery of novel disease - specific and membrane - associated candidate markers in a mouse model of multiple sclerosis.

Thus, as the inflammatory cascade progresses from nonatrophic gastritis through the atrophic gastritis — intestinal metaplasia — neoplastic spectrum, it was found that these 5 specific markers were statistically significant in predicting precancerous lesions in comparison to traditional risk factors (receiver operating characteristic, 0.803 vs 0.580).70 As discussed previously, intestinal - type gastric cancer is more strongly associated with the atrophic gastritis and intestinal metaplasia cascade, thus explaining the closer correlation with intestinal - type gastric cancer and the serologic biopsy than diffuse - type gastric cancer.

Oil droplets, outer, and inner segments were observed in cells expressing photoreceptor specific markers (Figure 7B and 7C).

In the present case, the diagnosis of BPDCN was challenging due to the absence of traditional lineage - specific markers and typical cutaneous presentation.

This molecular slingshot could «shoot» and deliver drugs at precise locations in the human body once triggered by specific disease markers.

Stage - specific embryonic antigen - 4 is not a marker for chondrogenic and osteogenic potential in cultured chondrocytes and mesenchymal progenitor cells.

Since different antibodies are markers of different diseases, this could become a very specific weapon in the clinician's hands.»

In this regard, known markers such as NT5E (CD73), ENG (endoglin; CD105), THY1 (CD90) are shared by both in vitro and in vivo MSCs, however other annotated markers such as STRO - 1, D7 - FIB, MSCA - 1 (W8B2), NGFR (CD271) appear to be rather specific to in vivo MSCIn this regard, known markers such as NT5E (CD73), ENG (endoglin; CD105), THY1 (CD90) are shared by both in vitro and in vivo MSCs, however other annotated markers such as STRO - 1, D7 - FIB, MSCA - 1 (W8B2), NGFR (CD271) appear to be rather specific to in vivo MSCin vitro and in vivo MSCs, however other annotated markers such as STRO - 1, D7 - FIB, MSCA - 1 (W8B2), NGFR (CD271) appear to be rather specific to in vivo MSCin vivo MSCs, however other annotated markers such as STRO - 1, D7 - FIB, MSCA - 1 (W8B2), NGFR (CD271) appear to be rather specific to in vivo MSCin vivo MSCs.

To determine pluripotency and AcGFP1 knockout efficiency in gesicle - treated cells, cells were labeled with a fluorescently labeled antibody specific to the pluripotency marker SSEA - 4.

In addition, the presenter will provide guidance on experimental design for multiplexed antibody panels combining phenotypic markers with phospho - specific intracellular targets, and discuss the use of fix and perm kits.

«It tells you about the ecosystem of the tumour», Simona says, «using fluorescent markers, we can label many specific cell types and structures within the brain in the vicinity of the tumour, and look not just at the tumour cells but how they interact with their surroundings.

Gender - specific alterations in fibrin structure function in type 2 diabetes: associations with cardiometabolic and vascular markers

Luckily, different cell types tend to have different things on their surfaces, which play particular parts in their specialized roles in the tissue, so it is a matter of identifying and targeting cell - surface markers that are specific to these abnormal cell types.