Sentences with phrase «specific markers expression»

Not exact matches

One of their goals at the conference was to pinpoint specific markers of these expressions, and then use them to identify the emergence of humans within the paleoanthropological record.

The results showed that, when applied, a long - term inhibition of Rho - kinase signaling increased the expressions of chondrocyte - specific genes and differentiation markers in human chondrosarcoma 2/8 cells.

The use of cell surface markers to isolate specific cell populations is one common method for separating cells; however, isolating live cells based on their RNA expression is a powerful new way enabling the study of small cell niches in nongenetically modified animal models and human tissue.

«There are indeed gene expression markers that predict drug - specific response,» said Dr. Porter.

Expanding from their previous studies with mice, the researchers first established that under specific conditions, culturing human embryonic stem cells with fibroblast growth factor 2 (FGF2) leads to neural differentiation particular to the midbrain / hindbrain region — the location of the cerebellum — within three weeks, and the expression of markers for the cerebellar plate neuroepithelium — the part of the developing nervous system specific for the cerebellum — within five.

Quantitative RT - PCR was used to measure the relative expression of macrophage markers (Emr1, Csf1r, Cd68) and an adipocyte - specific gene (Acrp30).

A short - term inhibition of Rho - kinase failed to induce extracellular matrix production in fibroblasts or in HCS - 2 / 8 cells, while its long - term exposure increased the expressions of chondrocyte - specific genes and differentiation markers, and also promoted the synthesis of sulfated glycosaminoglycans by chondrocytic cells.

The expression patterns of cell class - specific markers in mosaic retinas appeared the same in host and donor derived regions suggesting that donor cells generated all retinal cell classes in approximately normal ratios (Figures 5K — 5N and S2).

Normal anatomical structure and the expression of cell class - specific markers does not demonstrate normal cellular function and connectivity.

Control and gesicle - treated hiPS cells were assessed for AcGFP1 expression (green), labeled with an antibody specific to pluripotency marker Oct ‑ 4, visualized with a fluorescent - labeled secondary antibody (red), and nuclear - labeled with DAPI (blue).

Using this cell line we show that apparently undifferentiated ES cell cultures consist of at least three cell types defined by this lineage - specific low - level transcription and the expression of the ES cell markers Oct4 and Nanog.

ES cells can be described based on a characteristic morphology, the presence of cell surface markers such as SSEA - 1 and Pecam1, or the expression of the key transcription factors such as Oct4, Sox2, Nanog, and a number of ES cell - specific transcripts (ECATs)[4]--[6].

The lack of co-expression of pluripotency markers and lineage specific markers at the protein level despite robust co-expression of transcripts of both classes of gene suggests a role for post-translational regulation of expression, perhaps by small RNAs.

Although the secure vs. insecure attachment distinction has some predictive validity, disorganized attachment has far better documented links with specific types of psychopathology than do other types of insecurity.4, 9 Still, much less is understood about the mechanisms through which disorganized attachment affects the expression of psychopathology in the child, and whether it is a specific contributor or a more general marker for psychopathology in general.