Sentences with phrase «specific mechanism of action»

The specific mechanism of action has not been well documented though, as most studies have not drawn a clear line between blood levels of vitamin D and disease prevention.

A few devices are commercially available for this use, but the specific mechanism of action pertaining to those porous openings is contentious.

Not exact matches

Disconnected from the mother through a clean mechanism of molecular competition between anti-hormones and hormones, and catapulted toward the network of sewage system through the action of specific stimulators of the uterine myosins, the embryo ends its existence in an unspectacular fashion.

Jordi Mestres, coordinator of the IMIM and UPF research group on Systems Pharmacology at the Biomedical Informatics Program (GRIB) states «With this study we have contributed to complementing the detection of these quite unstable fragments, with information on the mechanism of action of the drug, based on three aspects: similarity to other medicines, prediction of their pharmacological profile, and interference with specific biological pathways.

The program works by connecting computer - generated drug profiles — including mechanisms of action, clinical efficacy, and side effects — with information about how a molecule may interact with human proteins in specific diseases, such as ovarian cancer.

The study, called «Molecular Determinants of Drug - Specific Sensitivity for Epidermal Growth Factor Receptor (EGFR) Exon 19 and 20 Mutants in Non-Small Cell Lung Cancer,» and published online in the journal Oncotarget, demonstrates how computer modeling of EGFR mutations found in lung cancer can elucidate their molecular mechanism of action and consequently optimize the selection of therapeutic agents to treat patients.

Quantitative proteomics can also be applied to identify major candidates of proteins targets and mechanism of action by specifically designed experiments using multiple drug / compounds in addition to that / those of interest and probing drug / compound - specific proteome responses to a treatment.

This model offers unique capabilities for preclinical assessment of thrombosis risk in a patient - specific manner, including efficacy testing of anti-thrombotic agents, elucidation of mechanism of action, and, potentially, biomarker identification, all providing a much - needed platform for drug discovery and development.

The comprehensive information presented for each cell therapy includes: an overview of the therapy, a list of therapeutic cells utilized in the specific treatment, mode and regimen of cell delivery, mechanism of action, formulation, in vitro data, animal models, preclinical data and related clinical trials.

Although they have distinct mechanisms of action, the lead agents from both platforms — CMB305 and G100 — where designed to convert «cold» tumors, or those without CTLs, to «hot» tumors, or those with CTLs specific for the antigens expressed by the tumor.

In order to validate that the observed cell death was specific to the action of amiodarone HCL, and possibly dissect the mechanism of action of this compound, we performed a gene expression analysis of NSCs and postmitotic neurons receiving amiodarone HCL.

Artichoke is one of the plants that have phytopharmaceuticals or active components, and some of its mechanisms identified, that have specific actions on the human body.

Topics include localization of brain function; general functions of specific brain areas; anatomy of the neuron; neurotransmission; mechanism of drug action on neurons; genetic, behavioral, and environmental influences on drug addiction; and addiction as a chronic disease.

This mechanism is worked into a lot of the game's puzzles as well; sometimes you'll need to alternate jumping between the pair, activate specific Mario and Luigi blocks with the appropriate Bro., or alternate actions between the two as some examples.

Proposed psychological and physiological mechanisms of action of MBRP and directions for future research are also examined with a specific focus on treating individuals recovering from alcohol use disorders.