Sentences with phrase «specific nucleotide»

Both the modification and the restriction enzymes become activated on a short specific nucleotide sequence, the recognition sequence, which is the substrate for methylation.

The goal of this project is to identify the specific nucleotide sequences and / or single nucleotide polymorphisms that are correlated with expression of virulence and disease via comparative genomic analysis between B. pseudomallei strains as well as between various bacteriophages harbored within B. pseudomallei.

In the presence of a donor DNA molecule with homology to the target region, the CRISPR system can also be used to introduce specific nucleotide modifications into a sequence of interest.

Moreover, the revelation of the braking system finally solves the decades - old mystery of why a single, specific nucleotide stimulates telomerase activity.

Particularly indispensable is the methylation of DNA, in which methyl groups are attached to specific nucleotides of double - stranded DNA.

Not exact matches

The specific sequence of nucleotides determines the various kinds of life that appear in evolution.

It is the specific arrangement of nucleotides along the chain of DNA which determines what that gene will do; it is the specific shape in three dimensions of a protein molecule which determines what sort of enzyme activity it will exhibit, and there are many other examples.

Microspheres are then able to use proteinoids as templates to make polynucleotides, which are themselves nonrandom because specific three - nucleotide sequences bind preferentially to specific amino acids.

Every tissue in an organism contains a variety of messenger RNA molecules, single - stranded nucleotide sequences bearing instructions for the making of specific proteins.

Instead they search specific regions of the genome for a type of mutation known as a single nucleotide polymorphism, or SNP (pronounced «snip»).

It is based on the design of a small RNA (RNAsg) that is complementary and specific to a 20 nucleotide DNA region.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

DNA is made of four substances — the nucleotide bases adenine, guanine, thymine, and cytosine — that will combine only in specific configurations and sequences.

Johnson's team borrowed a technique from cancer biology, called the systematic evolution of ligands by exponential enrichment (SELEX), which creates a huge library of random, short chains of nucleotides, called aptamers, and then incubates them with a target of choice, such a specific breast cancer cell.

When a Y chromosome is passed from father to son, the chance that a specific single nucleotide will change from, say, T (thymine) to A (adenine) is on the order of one in a few tens of millions.

To do that, Harvard's Alison Cloutier and the rest of the little bush moa team (which declined to talk about the work before its formal publication) took their 900 million nucleotides, scattered across millions of DNA pieces, and tried to match them to specific locations on the genome of the emu, a close relative of all nine moa species.

Extensive research has already examined the function of microRNAs, a category of small evolutionarily conserved noncoding RNAs about 22 to 24 nucleotides in length that target protein - coding genes in a sequence - specific manner.

During development, chromosomes are subject to chemical changes that don't affect the nucleotide sequence but can turn genes on or off; the best known example is methylation, in which a methyl group is attached to specific DNA regions.

These actions are specific for the sympathetic and parasympathetic neurotransmitters and for the two cyclic nucleotides, as phenylephrine, tyramine, choline, adenosine 5» - monophosphate and guanosine 5» - monophosphate do not inodify lysosomal enzyme release.

DNA mismatch correction is a strand - specific process involving recognition of noncomplementary Watson - Crick nucleotide pairs and participation of widely separated DNA sites.

Time - lapse crystallography was used by National Institute of Environmental Health Sciences (NIEHS) researchers to determine that DNA polymerase, the enzyme responsible for assembling the nucleotides or building blocks of DNA, incorporates nucleotides with a specific kind of damage into the DNA strand.

Two specific long - range interactions clamp the two halves of the domain together: a two - Mg2 + - coordinated adenosine - rich corkscrew plugs into the minor groove of a helix, and a GAAA hairpin loop binds to a conserved 11 - nucleotide internal loop.

To make the match more specific, Cas9 requires an additional sequence flanking the targeted 20 nucleotides: N - G - G, in which «N» can be any nucleotide.

For example, centenarians not only have retarded biological ages, they're also more likely to carry specific gene variations (called single nucleotide polymorphisms, or SNPs) that protect against disease.

piRNAs are small RNA molecules (26 - 31 nucleotides in length) that bind to a class of germline - specific proteins called PIWIs.

Each nucleotide on one long side of the ladder must pair with a specific one on the other side.

Moderna has developed a broad intellectual property estate, including more than 144 patent applications with more than 6,910 claims ranging from novel nucleotide chemistries to specific drug compositions.

Determinants of specific RNA interference - mediated silencing of human β - globin alleles differing by a single nucleotide polymorphism.

In this study, we have developed a new sensitive and specific one step rRT - PCR for detection of ZIKV in serum and cell culture supernatants using a Taqman probe containing locked nucleotides, in the NS5 region of ZIKV genome using sequences of ZIKV strains circulating in Africa and Asia.

Silence's specific siRNA molecules exhibit unique structural features which, irrespective of their individual nucleotide sequence, bar third parties from commercialising this type of molecule.

Allele - specific PCR, molecular cytogenetic studies, microsatellite PCR, Affymetrix single nucleotide polymorphism array analyses, and colony assays were undertaken on subgroups of patients.

A single DNA sequence is formed from a chain of four nucleotide bases and if some individuals in a population do not carry the same nucleotide at a specific position in the sequence, the variation is classified as an SNP.

Studying a specific type of genetic variation in the DNA sequences of wolves and domestic dogs - called Single Nucleotide Polymorphisms (SNPs)- the scientists identified the transfer of dog gene variants into wolf genomes.

In DNA, each protein is encoded by a gene (a specific sequence of DNA nucleotides that specify how a single protein is to be made).

Therefore, each tRNA has a specific three - nucleotide sequence called an anti-codon that matches up with the appropriate mRNA codon, like a lock and key.