Sentences with phrase «specific organ cells»

From these three cell populations different functional tissue cells arise, such as skin cells, muscle cells, and specific organ cells.

It exerts this control by regulating cell proliferation and transformation into specific organ cell types.

Not exact matches

RS: According to the hypothesis of formative causation, outlined in my book A New Science of Life, systems such as molecules, crystals, cells, organs and organisms are organized by specific morphogenetic fields, which give them their characteristic form and organization.

Specific maternal immune cells in the milk cross the wall of the baby's intestine to enter an immune organ called the thymus.

«If we fed the fish a specific type of fat, our technique allowed us to determine into what molecules these lipids were reassembled after they were broken down in the small intestine and in which organs and cells these molecules ended up,» Farber explained.

«We found the correct cell types homed in to specific regions in the organ matrix,» says Ott.

The scientists have shown that, in all cancers, a sort of «identity crisis» is observed in cancerous cells: in the organs or tissues in which a tumor develops, genes specific to other tissues or to other stages of the development of the organism express themselves in an aberrant manner.

To figure out what's really happening within an organism — or within a particular organ or cell — researchers are linking the genome with large - scale data about the output of those genes at specific times, in specific places, in response to specific environmental pressures.

Understanding exactly how stem cells form into specific organs and tissues is the holy grail of regenerative medicine.

Recent experiments, for instance, suggest that when an organ lacks LGR -5-positive cells, differentiated cells may be able to «dedifferentiate» and repair tissues — a radical change from the one - way street toward specific identities that stem cells were thought to travel.

A series of headline - grabbing results in the late 1990s and early this decade suggested that specific adult stem cells such as those from the blood seemed able to exceed expectations and transform themselves into other organs and tissues.

The method, which involves inserting genetic material that makes the cells» development run backwards, opens the door to stem cells specific to patients, which could be used to repair damaged organs or fight diseases such as Parkinson's and diabetes — crucially, all without the need to destroy human embryos.

During embryonic development, organ - specific cell types are formed from pluripotent stem cells, which can differentiate into all cell types of the human body.

Their goal is to learn how to coax stem cells to become specific tissues or organs.

Different types of tumors show a preference for specific organs and tissues; circulating breast cancer cells, for example, are likely to take root in bones, lungs, and the brain.

In this report, we found that CSCs (CD24 − / CD44 + / ESA +) isolated from metastatic breast cell lines are significantly more metastatic than non-CSC populations in an organ - specific manner.

Cells from each organ - specific line were plated onto two - chamber slides at a density of 1 × 105 cells / chamber and allowed to incubate overnCells from each organ - specific line were plated onto two - chamber slides at a density of 1 × 105 cells / chamber and allowed to incubate overncells / chamber and allowed to incubate overnight.

It is now possible to introduce mice strains (known as «knockout mice») in which specific genetic modifications can be activitated at specific times, or in specific cells or organs.

Durdu, a PhD student in Darren Gilmour's lab at EMBL, found this behaviour in specific groups of cells in the zebrafish: the cells that will develop into the animal's «lateral line», a series of ear - like organs along the fish's flank that allow it to sense changes in water pressure.

AHERF Neurosciences Grant (G9410 -020-Y01)- Co-PI; «Differential expression and sorting of the neuron - specific class III b - tubulin isotype in human neuronal and neuroendocrine tumor cell lines maintained in an organ culture system».

The Salk researchers stopped the cells from differentiating further, but each germ layer was theoretically capable of giving rise to specific tissues and organs.

«This data allows classification of all human protein - coding genes into those coding for house - hold functions (present in all cells) and those that are tissue - specific genes with highly specialized expression in particular organs and tissues, such as kidney, liver, brain, heart, pancreas.

His research contributions have enhanced an understanding of how these viruses enter into host cells and cause organ - specific disease.

In an application for a prestigious «Pioneer Award» from NIH this year, he proposed injecting human pluripotent stem cells into pig embryos whose genes for specific organs had been knocked out.

Pluripotent cells such as embryonic stem (ES) and induced pluripotent stem (iPS) cells are the starting point from which to generate organ specific cell types.

We can obtain iPS cells from an individual's skin or blood and program them into different tissue types to create patient - specific Organ - Chips.

We have developed pre-clinical models to identify genes, both in the tumour cells and in the microenvironment that regulate the spread of cancer to specific organs such as the liver, lungs and brain.

A better understanding of this master switch regulator may help to understand, how cells that have a common origin take on a specific fate in the body to build an organ and may also help to understand the development of certain leukemias.

Organ - specific stem cells are special because they can both develop into adult cells and replicate indefinitely.

Now researchers at UC San Francisco have taken the first step toward a comprehensive atlas of gene expression in cells across the developing human brain, making available new insights into how specific cells and gene networks contribute to building this most complex of organs, and serving as a resource for researchers around the world to study the interplay between these genetic programs and neurodevelopmental disorders such as autism, intellectual disability and schizophrenia.

Pluripotent stem cells, from a slightly later stage, can give rise to any specific tissue, but they fail to support more fundamental development such as growing organs for transplantation or building new mouse models.

Following the delineation of some of the basic principles behind bud formation, the researchers then whether they could extend this strategy beyond the liver, and create other organ buds using tissue specific cell types.

Perhaps a universal role for localized BR biosynthesis adjacent to boundaries of developing organs is to fine - tune cellular growth response in coordination with other cell - specific growth promoting or repressing factors.

Now, in a new study in Cell Stem Cell, the group have begun to delineate the mechanisms controlling organ bud formation, and from these findings they have been able to describe a general methodology for the formation of large vascularized, complex organ buds from diverse organs using specific stem cell combinations Cell Stem Cell, the group have begun to delineate the mechanisms controlling organ bud formation, and from these findings they have been able to describe a general methodology for the formation of large vascularized, complex organ buds from diverse organs using specific stem cell combinations Cell, the group have begun to delineate the mechanisms controlling organ bud formation, and from these findings they have been able to describe a general methodology for the formation of large vascularized, complex organ buds from diverse organs using specific stem cell combinations cell combinations [4].

Her group has developed pre-clinical models of metastatic disease that are used to identify genes, both in the tumour cells and in the tumour micro-environment that regulate the process of metastasis to specific organs such as bone, liver, lung and brain.

This two - volume reference integrates this exciting area of biology, combining the prerequisites for a general understanding of adult and embryonic stem cells, the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations, as well as a presentation by the world's experts of what is currently known about each specific organ system.

By introducing organ - specific cells, researchers can emulate different organs, such as the lung, liver, intestine, or brain.

We use what are called conditional knockout mice, in which a gene is deleted only in a specific organ or group of cells.

Engraftment of bioengineered vascular networks Juan Melero - Martin, Boston Children's Hospital Organ specific vascular niche - derived angiocrine factors induce specification and self - renewal of stem cells Shahin Rafii, Weill Medical College at Cornell A perfused Blood - Brain Barrier on a chip Christopher C.W. Hughes, University of California, Irvine

These can then be made into any organ cell type specific to the individual.

Complete phenotyping of the mouse immune system by polychromatic and mass cytometry (CYTOF), thanks to a set of standardised protocols enabling isolation of viable cells from lymphoid and non-lymphoid organs (lung, skin, intestine,...) for labelling using complex ranges of antibodies whose compatibility allows the simultaneous registration of 50 quantitative parameters at least (size, structure, specific antibodies and cell viability).

Organoids — miniature versions of organs grown in vitro from tissue - specific progenitor cells — were first produced in 2013.

Other cells are multipotent, meaning they can generate a few different cell types, generally in a specific tissue or organ.

In two studies published in Science and Cell Stem Cell, the team of scientists, who were led by Gladstone senior investigator Sheng Ding, PhD, and are part of the Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, used chemical cocktails to gradually coax skin cells to change into organ - specific stem cell - like cells and, ultimately, into heart or brain ceCell Stem Cell, the team of scientists, who were led by Gladstone senior investigator Sheng Ding, PhD, and are part of the Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, used chemical cocktails to gradually coax skin cells to change into organ - specific stem cell - like cells and, ultimately, into heart or brain ceCell, the team of scientists, who were led by Gladstone senior investigator Sheng Ding, PhD, and are part of the Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, used chemical cocktails to gradually coax skin cells to change into organ - specific stem cell - like cells and, ultimately, into heart or brain ceCell Biology and Medicine at Gladstone, used chemical cocktails to gradually coax skin cells to change into organ - specific stem cell - like cells and, ultimately, into heart or brain cecell - like cells and, ultimately, into heart or brain cells.

The role of invariant NKT cells in organ - specific autoimmunity.

• Personalized drug safety can be addressed with patient - derived cells in Organ - Chips, enabling a patient - specific approach for assessing the safety and efficacy of new candidates while taking into account patient variability and the unique biology of individual patients.

The work at the ESRF will help CRELUX / WuXi AppTec to support their clients in the discovery and development of novel and more specific drugs that can influence AMPK activity in the cell and, as a result, adjust the energy balance in disease affected organs.

Nanomedicines, for example, often encapsulate drugs in molecular packages decorated with segments of molecules that enable them to target specific organs and diseases, and, once there, convince those cells to ingest the medication.

The thymus is the small organ in the lymphatic system that makes T - cells, [29] which are highly specialized immune cells that target specific types and strains of microbes, like viruses.

It is important that proper diagnosis through the use of testing for autoantibodies — immune proteins that attack specific cells or organs in the body — has been done to confirm an autoimmune diagnosis.