Not exact matches
We have developed pre-clinical
models to identify genes, both in the tumour cells and in the microenvironment that regulate the spread of cancer to
specific organs such as the liver, lungs and brain.
Pluripotent stem cells, from a slightly later stage, can give rise to any
specific tissue, but they fail to support more fundamental development such as growing
organs for transplantation or building new mouse
models.
Her group has developed pre-clinical
models of metastatic disease that are used to identify genes, both in the tumour cells and in the tumour micro-environment that regulate the process of metastasis to
specific organs such as bone, liver, lung and brain.
Griffith believes that the most immediate applications for this technology involve
modeling two to four
specific organs.