Sentences with phrase «specific phenotypes of»

Visual exploratory behaviour in infancy and novelty seeking in adolescence: Two developmentally specific phenotypes of ADHD

I'll even use some specific phenotypes of mock guys.

Identifying the specific phenotype of the disorder is, therefore, an essential first step to providing effective care.

Not exact matches

«Phenocopy can be caused by other risk - modifying genes or exposure patterns that increase the probability of the specific phenotype manifesting itself,» says the study's first author Hildur Helgadottir, researcher at Karolinska Institutet's Department of Oncology - Pathology, Stockholm, Sweden.

The phenomenon whereby non-carriers of a specific mutation copy the phenotype (in this case melanoma) from their mutation - carrying relatives is known as phenocopy.

Alternatively, a breeder could, using individuals of differing phenotypes, create a new breed with specific characteristics.

The opposing functions of TAMs in the development of tumors arise the question whether there are specific factors within the micro-environment of the tumor which dictate the phenotype of these TAMs.

His current specific interest is the elucidation of novel mechanisms of drug resistance through the discovery / identification of novel gene function (s) and phenotypes using RNAi - mediated gene silencing or cDNA overexpression.

This requires the development of powerful bioinformatic approaches that allow prediction of haplotypes from numerous variants, and the classification of haplotypes into functionally related categories, in order to identify those specific sequence variants, or combinations of variants, associated with the disease phenotype.

«Metabolomics is now often used to accompany large genomic cohort studies from biobanks, to correlate genotype and genomic variants with specific phenotypes, to complement nutritional studies monitoring food components or endogenous metabolites, or to support measurements in epidemiology studies,» says Andreas Huhmer, director of proteomics and metabolomics marketing at Thermo Fisher Scientific, headquartered in Waltham, Massachusetts.

The means to enhance the production of cartilage - specific extracellular matrix is needed for cell - based tissue engineering applications, since cultured chondrocytes quickly lose their cartilage - specific phenotype.

Although the current study demonstrates that loss of IL - 15Rα promotes this phenotype, future studies are needed to determine the roles of specific IL - 15Rα isoforms in muscle, as well as the associations of additional IL15RA polymorphisms in muscle phenotypes in humans.

«It's one of the dream phenotypes — to have a defect that's regeneration - specific, where the neoblasts are working.

These observations were specific to the loss of IL - 15Rα, as knockout of IL - 15 and transgenic overexpression of IL - 15 did not result in altered exercise and muscle phenotypes.

Finally we aim at identifying phenotype specific transcriptional targets of mutant HTT (mut - HTT) or HTT loss of function in relevant neuronal / glial populations.

I have been fortunate to be able to identify an interesting phenotype (an exploratory behavior), explore the genetic architecture of the behavior, and ultimately identify and evaluate a specific genetic variant within the time span of a PhD.

Such alleles can also be referred to as «separation of function» alleles, because they allow dissection of the roles of multifunctional proteins in specific phenotypes.

We report a variety of biallelic effects on organismal phenotype attributable to combinations of recessive Xpd alleles, including the following: (i) the ability of homozygous lethal Xpd alleles to ameliorate a variety of disease symptoms when their essential basal transcription function is supplied by a different disease - causing allele, (ii) differential developmental and tissue - specific functions of distinct Xpd allele products, and (iii) interallelic complementation, a phenomenon rarely reported at clinically relevant loci in mammals.

Secondly, highlighting the potential relevance of current findings to all diploid organisms including humans was the observation that in one compound heterozygous animal, the Xpd allelic relationship could shift from Adominant arecessive to Arecessive adominant with respect to different phenotypes in a time - dependent and tissue - specific manner (see below and Table 2).

Reykjavik, ICELAND, 12 October 2011 — deCODE genetics today announced that it has entered into a research collaboration with Pfizer Inc., the objective of which is to discover sequence variants associated with specific clinical phenotypes related to Systemic Lupus Erythematosis by utilizing deCODE's expertise in gene discovery.

The severe vegetative phenotypes observed in PCZ - treated seedlings (e.g., dwarf and erect leaves) likely result from systematic inhibition of BR biosynthesis, as opposed to the inflorescence - specific loss affected by bsl1.

To analyse the extent of DNA damage response (DDR) in resistant phenotype, we treated spheroidal clonospheres with specific concentrations of Bleomycin.

Correspondingly, endothelial - specific deletion of Tie2 using Ve - cad - Cre driver mice, pursued in validating the Tie2fl / fl mice used in this study, essentially phenocopied the global Tie2 KO phenotype with embryonic lethality around E10.5 (Supplementary Fig. 13), confirming the key role of endothelial Tie2 during embryonic development.

More recent work by Aggarwal and Pittenger 82 supported the feasibility of MSC - transplantation showing that MSC altered the phenotypes of specific immune cell subtypes thereby creating a tolerogenic environment.

Interaction of human mesenchymal stem cells with cells involved in alloantigen - specific immune response favors the differentiation of CD4 + T - cell subsets expressing a regulatory / suppressive phenotype.

These analyses demonstrated very unique and specific features of the susceptible versus control mice, which include a hypoactive and anxious phenotype with reduced mobility, rearing, digging and sniffing as well as increased freezing and exploratory stretching behavior.

She has discovered several novel disease specific cellular phenotypes in their in vitro models, many of them involved in accurate performance of the neural progenitors.

PHENOMIN - ICS offers to generate genetically modified mouse models on a high - throughput and large scale basis, and then to provide a first phenotyping characterisation, either standardised or more specific, for a better understanding of disease mechanisms and for the development of new therapeutic treatments.

Summary: A two day meeting to review current IMPC progress and discuss future developments such as CRISPR - Cas9 implementation and a mouse ageing pipeline, including several Infrafrontier IPAD - MD sponsored expert group meetings on specific areas of mouse phenotyping Attended by: IMPC members, funders, corporate sponsors, IMPC Panel of Scientific Consultants & invited external researchers Hosted / funded by: Korea Mouse Phenotyping Consortium / Inphenotyping Attended by: IMPC members, funders, corporate sponsors, IMPC Panel of Scientific Consultants & invited external researchers Hosted / funded by: Korea Mouse Phenotyping Consortium / InPhenotyping Consortium / Infrafrontier

CCP covers a full spectrum of genetic engineering services, strain cryopreservation and archiving services, advanced phenotyping and imaging services, as well as specific pathogen free (SPF) animal housing and husbandry.

To characterize activation of immune cells, measurement of intracellular signaling using phospho - specific antibodies combined with immune phenotyping using surface markers is ideal.

The successful candidate will leverage the extensive mouse - specific resources of The Jackson Laboratory in combination with classic mouse genetics, current ocular phenotyping and molecular biological techniques, and advanced technologies, such as CRISPR and single - cell RNA - Seq, to address his or her scientific questions.

Although much is known regarding the specificity and efficacy of antibody responses, our knowledge of the function, phenotype, and specificity of the antigen - specific B cells that are responsible for antibody production, as well as for long - term humoral memory, is inadequate.

The SMDC has allowed Gladstone scientists to design molecules to modulate the functions of proteins or specific cellular phenotypes and, most significantly, screen for drugs that could be used as therapies for disease.

Complete phenotyping of the mouse immune system by polychromatic and mass cytometry (CYTOF), thanks to a set of standardised protocols enabling isolation of viable cells from lymphoid and non-lymphoid organs (lung, skin, intestine,...) for labelling using complex ranges of antibodies whose compatibility allows the simultaneous registration of 50 quantitative parameters at least (size, structure, specific antibodies and cell viability).

Baseline medical conditions, such as previous myocardial infarction, stroke, hypertension, diabetes, and hypercholesterolemia, were defined as a history of physician diagnosis, measured phenotypes that met clinical thresholds for a specific condition, or, when appropriate, the combination of both methods.

CD8 T cells specific for the noninflationary M45 epitope displayed a classic central memory phenotype, re-expressing the lymph node homing receptor CD62L and homeostatic cytokine receptors for IL - 7 and IL - 15, and produced low levels of IL - 2.

Furthermore, CMV - specific CTL have a highly polarized membrane phenotype that is typical of effector memory cells (CD28 -LRB--), CD57 (+), CCR7 -LRB--)-RRB-.

Although the genes implicated in these disorders are involved in a variety of pathways, most of them share a molecular phenotype: high (and often transcript ‐ specific) expression in retinal tissue.

Furthermore, loss of function of mammalian Boule resulted in male - specific infertility and a global arrest of sperm development remarkably similar to the phenotype in an insect boule mutation.

The functional activity of the herpesvirus - specific immune response decreases in elderly donors, although the characteristic phenotypes of CMV - and EBV - specific memory populations are retained.

To define the phenotype and function of specific cellular populations involved in the cross-talk between cancer and immune cells we make use of both flow - cytometry and mass - cytometry.

Reykjavik, ICELAND, 12 October 2011 — deCODE genetics today announced that it has entered into a research collaboration with Pfizer Inc., the objective of which is to discover sequence variants associated with specific clinical phenotypes related to Systemic Lupus...

This observation suggests that activation of the JAK - STAT pathway and the RAS — mitogen - activated protein kinase (MAPK) pathway can cooperate in CMML, and suggests that the possibility that additional mutations in JAK2V617F mutant hematopoietic progenitors may direct the eventual disease phenotype in specific patients.

A thorough longitudinal analysis of the CMV - specific T cells in nonagenarians showed a stable pattern with respect to frequency, phenotype, and clonal composition.

Genome - wide patterns of isolation do not provide direct information regarding the mechanisms or phenotypes that contribute to reproductive barriers, underscoring both the power of this population genetic approach because it is not constrained by choice of a specific phenotype, but also its limitations.

We found using unbiased genetic screening that different miRNAs could elicit specific morphological phenotypes that often closely resemble deregulation of known developmental regulators or signaling pathways.

Objective: We carried out de novo recruitment of a population - based cohort (MANOLIS study) and describe the specific population, which displays interesting characteristics in terms of diet and health in old age, through deep phenotyping.

For each mouse line, Lexicon provided not only the mouse strain itself, but also detailed, objective data on the impact of the specific gene deletion on the mouse's phenotype, which includes appearance, health, fitness, behavior, ability to reproduce, and radiological and microscopic data.

Topics of interest include gene - environment interactions, genetic associations with asthma - associated phenotypes such as allergies and lung function, and the role of tissue - specific gene expression.