This increased incidence was driven by
specific primary immunodeficiency disorders predisposing to specific cancers, particularly lymphoma.
Not exact matches
When Roswell Park Cancer Institute (RPCI) researchers evaluated the overall and site -
specific incidence of cancer among patients registered in the United States Immune Deficiency Network (USIDNET), they found increased cancer incidence rates among patients with
primary immunodeficiency diseases — and, in particular, a significant increase in lymphoma cases.
By means of a non-obese diabetic / severe combined
immunodeficiency disease (NOD / SCID) xenotransplant assay in combination with
specific cell surface markers (CD44 + CD24 - / low), CSCs were enriched from metastatic and
primary breast tumors and were shown to have the ability to reestablish tumor heterogeneity after transplantation [1].