Sentences with phrase «specific roles in disease»

Not exact matches

«Scientifically, she worked on a project that not only revealed an important role for a specific growth factor (VEGF) in the physiology of an ocular structure called the ciliary body but she also demonstrated that there might be unexpected and undesired side effects from a widely used treatment for a variety of ocular diseases.

Next steps for the team include identifying microbiota metabolites whose levels are either significantly elevated or depleted during diseases such as IBD or cancer, to find disease - specific markers and explore possible roles for these metabolites in disease progression.

Thus, based on the robust findings from the current study and until proven otherwise, WBRT may still have an important role for treatment of patients who are not in this specific disease category (i.e., 1 - 3 brain metastases).

Neuroscientists have discovered a specific enzyme that plays a critical role in spinal muscular atrophy, and that suppressing this enzyme's activity, could markedly reduce the disease's severity and improve patients» lifestyles.

The researchers predicted that the TRPC5 mechanism might play a similar role in other types of progressive kidney disease — even if, in those cases, the damaging feedback loop was kickstarted from chronic disorders such as high blood pressure, rather than a specific genetic mutation.

Using cells from mice and human livers, Toronto General Hospital Research Institute researchers demonstrated for the first time how under specific conditions, such as obesity, liver CD8 + T cells, white blood cells which play an important role in the control of viral infections, become highly activated and inflammatory, reprogramming themselves into disease - driving cells.

«While we are only just beginning to understand the complex roles microbes play in human biology, it is clear specific changes in microbial flora are associated with — and sometimes cause or cure — disease in the host,» said Pollard while explaining her research focus.

By pairing engineered cell lines containing disease - specific mutations with high throughput screening, we can investigate the role of given mutations in the biology of disease as well as identify potential druggable targets.

His uses genome engineering methods to test the role of specific genetic changes in induced pluripotent cell (iPSC)- derived models of disease.

The first of its kind, the study provided specific markers to distinguish different disease states in asthma and paved the way for investigating the role of epigenetic mechanisms in other immune - mediated disorders and infectious diseases.

Rapidly evolving approaches to the comprehensive profiling of patients» risk factors, such as whole - genome sequencing, will play an increasingly important role in overcoming neurological disease, in much the same way as these approaches are already used to match up certain cancer patients with specific drugs they stand to benefit from the most.

As one of the three initial cores established when the Buck Institute was founded, the Genomics Core has played a vital role in helping shape investigations in the basic molecular biology of aging, from assisting in the investigation of how specific drugs can extend lifespan in simple model organisms such as the nematode C. elegans, to facilitating studies in various animal models of age - related disease.

The foundations — which are often associated with specific diseases — have also played a very positive role in bringing together all these different groups and getting them to work effectively together.

We are currently employing our new genetic tools for mast cell - specific inactivation of loxP - flanked genes and for inducible ablation of mature mast cells in adult animals to clarify the roles mast cells play in neoplastic disease.

Candidate gene - a gene that might be relevant to a specific canine disease due to the gene's role in a similar disease in another animal or human.

In this way, natural and human climate influences can be separated, and as with disease and risk factors, the role of a specific factor in a specific outcome can be quantifieIn this way, natural and human climate influences can be separated, and as with disease and risk factors, the role of a specific factor in a specific outcome can be quantifiein a specific outcome can be quantified.