Sentences with phrase «specific signaling molecules»

It activates specific signaling molecules, which leads to induction of genes that contribute to cell damage.

Long - lasting changes in brain connectivity require new gene expression, and Dr. Martin has discovered a role for specific signaling molecules that travel from stimulated synapses to the nucleus to change the transcription of DNA to RNA.

By culturing human stem cells in this manner and treating them with specific signaling molecules, the investigators were able to guide cells through key processes involved in the development of the human inner ear.

Using an animal model, they found that TIMP - 1 recruits immune cells by increasing the levels of a specific signaling molecule in the liver.

Not exact matches

In the direct reprogramming, the researchers exposed the adult skin cells to a specific mix of signaling molecules the scientists» past research had found would convert healthy skin cells directly into a type of brain cell called medium spiny neurons, without intermediate steps along the way.

Receptors are «molecular switches» — when a specific molecule binds to them, they change shape and send a signal to the cell to perform a certain function.

Using small - molecule inhibitors to eliminate the activity of the proteins produced by the bird - specific, median signaling zone in chicken embryos, the researchers were able to induce the ancestral molecular activity and the ancestral anatomy.

The rapidly proliferating cells, they found, also sported a specific cell - signaling molecule.

Zitvogel's team found that a specific immune signaling molecule, or cytokine, called IL12 that is released in response to A. muciniphila may help rally the T cells.

Remarkably, giving animals injections of lithium salts — which mimics WNT signaling by inhibiting the molecule GSK3 — or giving animals a more specific GSK inhibitor, the researchers were able to restore normal synapse and spine numbers and also improve some of the most significant psychiatric - like behavioral abnormalities in these mice.

That signal, he predicted, would come from cells pre-installed with receptors that lock onto specific molecules found on viruses,...

Notably, the molecule failed to improve metabolism in mice lacking either the glucagon receptor or which lack the thyroid hormone receptor in only the liver, demonstrating the liver - specific signal specificity of this new molecule.

«Our research revealed how small RNA molecules can work with other cell signals called transcription factors to generate specific types of neurons, in this case motor neurons.

When the researchers added a specific bone morphogenetic protein called BMP4, as well as another signaling molecule called retinoic acid, to human embryonic stem cells, they got a mixture of two types of sensory interneurons.

The team, led by Ashleigh Theberge, Assistant Professor, Department of Chemistry, will create new analytical chemistry and engineering tools that pull out key molecules from a mix of molecular noise in order to selectively «listen» to molecular signals produced by specific fungi, bacteria, or human cells.

Timothy Springer, with colleagues Michael L. Dustin and Charles A. Dinarello, identifies and characterizes adhesion molecules, a class of cell surface proteins that function in the interactions of immune cells with other cells, including antigen - specific recognition and cell trafficking: integrin LFA - 1 involved in cytoskeleton and signaling, and intracellular adhesion molecules (ICAMs), which are binding partners (ligands) for LFA - 1 and are increased in inflammatory and autoimmune disease.

He developed an innovative microdialysis approach that allows the in vivo sampling of lipid signaling molecules in the brain (including endocannabinoids) and has demonstrated that voluntary self - administration of ethanol, heroin, and cocaine produces distinct drug - and region - specific changes in brain endocannabinoid levels.

De novo rational design of molecular scaffolds mimicking protein interactions for specific interference in cell signaling processes: We apply molecular modelling and computer simulation techniques for designing molecules with pharmacological / biotechnological interest.

Specific identifying molecules, called antigens, found on or in offending cells signal the presence of danger.

«We're following up on this work by asking if there are specific [cellular] RNA molecules that stimulate the MDA5 signaling,» she adds.

Development of inhibitors of metabolic pathways to block oncogenes or signalling molecules in malignant processes and specific inflammatory processes, such as pulmonary artery hypertension or idiopathic pulmonary fibrosis.

Surprisingly, small molecule activators of PKA signaling increase expression of Oct4 protein, which in turn enhances expression of a specific subset of Oct4 target genes.

In well - designed FRET - based biosensors, the intensity of the FRET signal can be correlated to specific concentrations of biological molecules.

Finally, the strategy applied here for selective delivery of MK801 can be extended to other small molecules for use in brain tissue (Tian et al., 2012), allowing for an approach that combines chemistry, molecular genetics, and neurobiology to dissect cell signaling pathways in specific cell types in the central nervous system.

By utilizing the tools of cell and molecular biology, he studies the mechanisms by which chemical (for example, specific cell adhesion molecules) or mechanical signals (for example, cyclic strain) are sensed by cells and alter their proliferation and specialization to either promote tissue growth or destruction.