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Not exact matches
«Our
data suggests that targeting
specific immune cell
subsets at defined stages
of disease may represent a better approach to therapeutic immunomodulation to improve heart failure.»
Although similar numbers
of total splenic gp33 - LCMV —
specific T cells were observed between genotypes (Fig. 5B), the distribution
of gp33 - LCMV —
specific CD8 + T cell effector and memory
subsets were altered, such that there was a significantly lower percentage
of short - term effector T cells and reciprocal changes in memory precursor cells among gp33 - specifc CD8 + T cells in WT relative to DKO mice (Fig. 5C), with a trend in changes in absolute cell numbers, consistent with temporal
data from peripheral blood (Fig. 5A).