Sentences with phrase «specific therapeutic target»

To do that, large compounds libraries are tested on a biological model showing a specific therapeutic target.

Therefore identifying the essential, tissue - specific effectors of Hh has the potential to lead to the identification of more specific therapeutic targets.

Despite this clinical importance, the exact pathologic process of tumor metastasis is as yet poorly understood, and deciphering the exact molecular mechanism of this process is of paramount importance to identify specific therapeutic targets for this devastating disease.

The patterns of these polymorphic genes and their expression profiles comprise the molecular signatures of unique pathophenotypes, offering the promise of diagnostic, prognostic, and therapeutic specificity; the definition of disease becomes «personalized», as does its specific therapeutic targets.

This work will provide valuable insight into the role of microglia within canine DM disease progression and could identify key areas for the development of microglia - specific therapeutic targets that could slow or halt further disease progression.

Not exact matches

And what that means, says Joe Panetta, CEO of the biotech association Biocom, is that those same startups will be able to develop diagnostic tools and therapeutic drugs that target those specific mutations.

Abnormal BMIPP identifies specific myocardial injury which could be an effective therapeutic target for preventing sudden cardiac death.»

The continuation of this line of research is opening new avenues to identify what specific signals are used to promote this increased neurogenic response, with views focused in targeting neurogenesis as a therapeutic approach to promote the regeneration of lost neurons.»

«If they can develop a family of specific particles to target the major toxin families specifically, then this approach would have real value as a therapeutic.»

«Our data suggests that targeting specific immune cell subsets at defined stages of disease may represent a better approach to therapeutic immunomodulation to improve heart failure.»

«Clinicians lack specific guidance to target their therapeutic interventions to maximize impact on outcome.

A new method has been found for identifying therapeutic targets in cancers lacking specific key tumor suppressor genes.

The computational protocol, which was validated by assembling physical peptides in the chemistry lab and comparing them to the computer models, may one day enable drug developers to craft novel, therapeutic peptides that precisely target specific disease - causing molecules within the body.

«These findings could lead to a new therapeutic strategy for patients with AML and potentially other diseases by targeting patients whose leukemia cells display activation of a specific survival pathway.»

But, these squishy packages are hard targets for potential therapeutic and diagnostic applications that exploit nanomaterials, from quantum dots that light up specific tissues to nanocages carrying drug payloads.

«A better understanding of the brain region and cell type - specific binding targets of Hnrnph1 will tell us more about the function of this gene and possibly identify new therapeutic strategies for minimizing risk and treating psychostimulant addiction — a disorder for which there is currently no FDA - approved drug,» explained corresponding author Camron Bryant, PhD, assistant professor of Pharmacology and Experimental Therapeutics & Psychiatry at BUSM.

Targeted gene therapies, however, had to wait for (1) the identification of the genes to target, (2) the cloning and / or sequencing of the relevant genes and in some cases, the specific disease - causing variant, (3) a full understanding of the normal gene function and regulation, and (4) the development of efficient ways to deliver genes to the relevant tissues at therapeutic levels.

By inducing a stable, complete knockout of specific genes, CRISPR - Cas9 may offer a superior means of identifying genes representing attractive therapeutic targets.

Scientists at the University of York have identified a therapeutic target which could lead to the development of new treatments for specific blood cancers.

The advancement of the Cas9 - based platform for screening and validation will help further the development of new therapeutic products, and Caribou's CRISPR - Cas9 technology can utilize guide RNAs specific for unique sequences and target a gene at numerous sites and therefore provide enhanced specificity.

These findings highlight the potential of Nav1.1 and inhibitory interneurons as a therapeutic target in AD and that disease - specific molecular optimization of cell transplants may be required to ensure therapeutic benefits in different conditions.

Understanding these pathways helps identify therapeutic targets and is critical for the design of tumor - specific, less toxic therapies.

Our group has 3 major goals: Develop novel therapeutic approaches based on centrosomal clustering To further develop our first prototype inhibitors of centrosomal clustering preclinically and to establish a robust and specific high throughput small molecule screen Discover key events in myeloma pathogenesis To investigate the pivotal transition from the pre-malignant, asymptomatic to malignant, symptomatic stages of plasma cell dyscrasias in order to understand the pathophysiology and thereby identify novel targets Translate small molecule therapeutics from bench to clinical trials To evaluate novel agents in the preclinical setting and to initiate early phase clinical trials in hematologic malignancies with focus on multiple myeloma

In this protein, the binding domain of botulinum toxin is replaced to broaden the toxin's therapeutic potential and allow drug development to be targeted towards a specific disease.

These mutant kinases are attractive therapeutic targets, as demonstrated by the efficacy of imatinib in BCR - ABL — positive chronic myelogenous leukemia (CML), 5 as well as in MPD associated with activating alleles involving PDGFRA or PDGFRB.2, 6,7 In addition, activating mutations in the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknown.

The therapeutic target goal is a constant preoccupation which translates into the organisation of teams focused on specific aims and time lines.

Because viruses have evolved such effective methods for finding their target and utilizing the host cells» own molecular machinery, scientists are modifying viruses into long - lasting therapeutic vehicles that can deliver drugs to specific cells or tissues or selectively target and destroy tumors.

This research was effectuated to create a theranostic bioconjugate with an optimal effective therapeutic index, achieved by biomarker - specific targeting.

Provenge and other therapeutic vaccines involve personalized therapy that targets the patient's specific tumor.

Treatment will usually include manual therapy to restore healthy joint and soft tissue range of motion, therapeutic exercises to target particular areas of weakness identified in your evaluation, and dance - specific training to help you refine your technique in ways that can reduce pain and support your growth as a dancer.

I have been experimenting with personalised fasting protocols lately, allowing for what I feel could be a theoretically viable symbiotic relationship of periodic, habitual therapeutic fasting + complimentary dose specific supplementation of fish oils + salt preparations + magnesium chloride supplementation as a specific, targeted, individualistic approach.

In this course, we will learn the anatomy of the digestive tract, targeted interventions for specific conditions, as well as therapeutic foods and supplements that can be used to heal the gut.

So, as modern science discovers more about the therapeutic benefits of camel milk, specific components could be used in a more targeted ways to combat illness.

• Determine types of therapies required for each child and develop specific therapeutic treatment plans to meet his or her individual needs • Handle assessments by interviewing and observing children and creating psychological profiles • Create new programs, move targets forward and make procedural changes in existing care / educational programs • Lead special education trainings and plan and implement staff development and patient education autism programs • Confer and communicate with staff members to gauge the effectiveness of special education programs

In addition, the patient - centric focus emphasises customised therapeutic approaches to target patients» specific needs.36 In designing this current intervention, we infused elements of cognitive — behavioural therapy and supportive therapy.

Direct therapeutic intervention, such as one - on - one therapy sessions or therapeutic playgroups conducted by a licensed or certified mental health professional, is designed to provide targeted assistance to a specific child experiencing mental health issues.

The KITS Follow - Up study was a longitudinal study of the effects of an intervention that targeted specific school - related skills during the summer and early fall preceding school entry via three mechanisms: (1) a therapeutic playgroup; (2) caregiver psychoeducational support groups; and (3) behavioral consultation in the home, school, and community settings.