Sentences with phrase «specific transcription factors in»

Bivalent marking of loci encoding lineage specific transcription factors in ES cells is thought to prepare these genes for rapid activation of transcription once the pluripotency network is extinguished [4].

Not exact matches

However, each time a cell divides the specific binding pattern of the transcription factors is erased and has to be restored in both mother and daughter cells.

Glk1 is a transcription factor, meaning it binds to specific regions of DNA and activates genes involved in cell death and other plant immune responses.

Thus, this cDNA derives from a gene (oct - 2) that specifies an octamer binding protein expressed preferentially in B lymphocytes, proving that, for at least one gene, a cell - specific transcription factor exists and its amount is controlled through messenger RNA availability.

«Many thyroid diseases will be impacted by changing the expression levels of the thyroid - specific transcription factor, so we want to investigate FOXE1 more carefully in future work.»

It is situated just next to a thyroid - specific transcription factor, a protein that regulates the rate of gene expression in the thyroid.

Gray and cyan ribbons, Mtb RNAP; yellow and orange ribbons, transcription initiation factor sigma; red and pink ribbons, DNA (specific sequence elements in blue).

The predictors include «Online Mendelian Inheritance in Man» (OMIM, a list of genetically caused diseases), receptors, kinases, growth factors, transcription factors, tissue specific, plasma membrane localization, nuclear localization and conversation index.

The activity of each gene then was analyzed in an attempt to find the specific transcription factor responsible for regulating the conversion of sugar to starch in the above - ground portions of the plant, primarily the grains.

«Our research revealed how small RNA molecules can work with other cell signals called transcription factors to generate specific types of neurons, in this case motor neurons.

Previously, in the region that controls the function of the transcription factor that promotes differentiation from ES cells to a specific cell type, bivalent modifications of histones such as the accelerator and brake histone marks for transcription were thought to have coexisted.

«We know that transcription factors bind to specific sites in the genome and when they misfire they drive many diseases, including cancers,» explains lead study author Graham Erwin, a former graduate student in the lab of Aseem Ansari, a professor in the Department of Biochemistry and the Genome Center of Wisconsin.

What they found was that when they overexpress transcription factors that drive the specification of specific subtypes of neurons in other cells in C. elegans, these do not by themselves cause the cell to convert into neurons.

So what we think is that probably in many cells in this section, all cells, the chromatin is encountered in a specific state, and in order to render the cell is permissive to reprogramming, you have to overcome these certain epigenetic modifications that block, for example, the binding of Ascl1 to its target chains, or the binding of other transcription factors to its target chains, then this way interfere with the possibility of reprogramming.

For example, his group looked at specific signaling pathways and transcription factors expressed in their pre-HSCs.

Finally, I will show how we have combined our results to generate a model of hematopoietic differentiation where specific transcription factors control lineage regulatory regions; our model predicts many already known lineage - controlling factors as well as finds new potential regulators of hematopoietic differentiation such as ATF3 in monocytes and Tcf7l2 and Runx2 in NK cells.

This, in turn, because the scientists did not know which DNA sequences are functional, and bind to the specific proteins called transcription factors that regulate gene expression.

In response to signals from inside and outside cells, transcription factors attach to the DNA and cause specific genes to be more or less activated, producing more or less of the corresponding protein.

Using chromatin accessibility and gene expression measurements, we present clear evidence that lineage specific enhancer dynamics in hematopoiesis is the result of lineage specific transcription factor activity.

A famous example of how transcription factor expression can be used to alter a cell's identity is the creation of iPSCs, where adult cells were forced to express transcription factors normally expressed in ESCs, which made the adult cells express genes specific to ESCs, and consequently become nearly identical to ESCs.

These include molecular evolution of transcription factors or changes in transcriptional regulation (Enard et al., 2002; Konopka et al., 2009), accelerated evolution of small non-coding RNAs (Pollard et al., 2006), changes in the tissue - specificity of enhancer elements (McLean et al., 2011; Prabhakar et al., 2008), or changes in patterns of alternative splicing of specific genes (Calarco et al., 2007).

The GDDS laboratory was responsible for first identifying the transcription factor SOX10 as a key lineage - specific regulatory factor in melanocytes that is mutated congenitally in individuals with Waardenburg syndrome IV.

In contrast, many scientists consider that chromatin does not form an independent epigenetic layer of the genome and that chromatin modifiers do not operate independently of a DNA sequence specific targeting mechanism, such as transcription factors.

In addition, well - characterized expression profiles for melanoma cells have been identified that correlate highly proliferative cell states with increased expression for pathways regulated by the lineage - specific transcription factors SOX10 and MITF; conversely, migratory / invasive cell states have been correlated with TGFβ1 signaling pathways.

In particular, understanding how transcription factors (TFs) bind in a sequence specific manner to the DNA and how the alteration of transcriptional regulation contributes to canceIn particular, understanding how transcription factors (TFs) bind in a sequence specific manner to the DNA and how the alteration of transcriptional regulation contributes to cancein a sequence specific manner to the DNA and how the alteration of transcriptional regulation contributes to cancer.

Dmrt1 (Doublesex and mab - 3 related transcription factor 1) was a testis - specific positive control in chicken [82] and Bnd (Bindin) was a testis - specific positive control in the sea urchin [83].

The 1500 transcription factors (TFs) within the human genome perform a key role in determining the set of active genes within a specific cell, as well as the magnitude of activity.

Here we measure allele - specific transcription factor binding occupancy of three liver - specific transcription factors between crosses of two inbred mouse strains to elucidate the regulatory mechanisms underlying transcription factor binding variations in mammals.

These 45 variants are significantly enriched for protein - coding changes (n = 13), direct disruption of transcription - factor binding sites (n = 3), and tissue - specific epigenetic marks (n = 10), with the last category showing enrichment in specific immune cells among associations stronger in Crohn's disease and in gut mucosa among associations stronger in ulcerative colitis.

To be more specific, we searched for transcription factors that were changed in NSCs after exposure to amiodarone HCl but showed no change in differentiated cells after treatment with equivalent amounts of the drug.

The overall goal of the core is to provide support to investigators interested in characterizing the interactions of post-translational modifications of histones (epigenetic marks that define a chromatin state or Epigenome) or transcription factors at specific genomic loci or genome - wide (Cistrome).

The pluripotent population is characterized by a high degree of plasticity in chromatin structure [3], and lineage specific transcription factors show bivalent chromatin epigenetic marks characteristic of both suppression and inactivation [4].

Specifically, we have generated clusters of transcripts that behave the same way under the entire spectrum of the sixty - seven experimental conditions; we have assembled genes in groups according to their time of expression during successive days of ES cell differentiation; we have included expression profiles of specific gene classes such as transcription regulatory factors and Expressed Sequence Tags; transcripts have been arranged in «Expression Waves» and juxtaposed to genes with opposite or complementary expression patterns; we have designed search engines to display the expression profile of any transcript during ES cell differentiation; gene expression data have been organized in animated graphs of KEGG signaling and metabolic pathways; and finally, we have incorporated advanced functional annotations for individual genes or gene clusters of interest and links to microarray and genomic resources.