Sentences with phrase «specific tumor suppressor genes»
«We reasoned that this retained synthetic essential gene might be required for cancer - promoting actions when the cancers lose specific tumor suppressor genes.»
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«Identifying targets essential to cell survival in tumor suppressor genes has long been an investigational goal with the aim of offering cancer - specific vulnerabilities for targeted therapy,» said Ronald DePinho, M.D., professor of Cancer Biology, MD Anderson president, and senior author for the Nature paper.
A new method has been found for identifying therapeutic targets in cancers lacking specific key tumor suppressor genes.
But the idea fell out of fashion as researchers began to discover that mutations in specific oncogenes and tumor - suppressor genes could set cancer in motion.
His group uses genome - wide and gene - specific DNA methylation analysis to identify aberrantly silenced tumor suppressor genes in B cell leukemias and lymphomas.
Other animal models either express oncogenes in a tissue - specific manner or shut down the expression of tumor suppressor genes in the whole tissue.
These rearrangements involved PGBD5 - specific signal (PSS) sequences at their breakpoints and recurrently inactivated tumor - suppressor genes.