The prognosis for pets diagnosed with intestinal tumors will depend on a variety of factors, including
the specific tumor type, the stage of the disease and whether the cancer has spread to other organs.
A specific tumor type can be suspected from its appearance on a CT or MRI, but can only be definitively identified by taking a sample of the tumor, either at surgery or by biopsy.
A small sample of the tumor is removed to determine
the specific tumor type.
By exploiting these differences, scientists have developed therapies that target
specific tumor types, and these targeted therapies have proven useful against most breast cancers.
Primary treatment for
specific tumor types Indications for the use of external beam radiation therapy for the primary treatment of tumors has expanded significantly with the emergence of SRS for pets.
Indications for radiation therapy (RT) include the primary treatment of
specific tumor types, such as nasal tumors and brain tumors, adjuvant treatment of incompletely excised tumors, and palliation to improve quality of life for patients with non-resectable or advanced cancers.
The scientists are also continuing to investigate mutations that occur in the tumors themselves (somatic mutations) and are profiling the susceptibility of
specific tumor types to various chemotherapy compounds, which may lead to improved therapy options.
Not exact matches
So research teams began souping up various
types of immune cells and even targeting them to
specific protein markers on
tumors.
«Shifting bacterial communities in the stomach may influence cancer risk: Microbe changes linked with
specific conditions could explain differences in risk and
type of
tumor.»
«Just as normal cells with the same genome differentiate into many different cell
types, a single
tumor characterized by
specific genetic mutations can contain many different
types of cells — stem - like and more differentiated cells — with the difference being rooted in their epigenetic information.
Most cancer vaccines developed to date have been designed to recognize and attack a
specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that
type of
tumor.
«Each
tumor type may acquire a unique set of capabilities that may provide
tumor -
specific growth and survival advantages, which may need to be determined for each kind of cancer.
In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three
specific cells are in direct contact: an endothelial cell (a
type of cell that lines the blood vessels), a perivascular macrophage (a
type of immune cell found near blood vessels), and a
tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.
This is important because
tumors are not all alike and some
types of
tumor cells may respond differently to a
specific drug than others, Skala pointed out.
Some cell
types were not killed by treatment with PAL, suggesting it could be used as a
specific tumor therapy.
«Not only did we find that LIGHT expression promoted
tumor regression, upon further study we also identified the
specific type of T - cell — CD8 — that was responsible for shrinking the
tumor,» Maker said.
A relatively new biomarker called prostate -
specific membrane antigen (PSMA) is the bullseye for three new magnetic resonance imaging (MRI) agents that bind to the protein in not only prostate cancer, but a range of
tumor types, according to research unveiled at the 2015 annual meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI).
Another possibility that Irvine's lab is working on is developing treatments that could be used against
tumors even when scientists don't know of a
specific vaccine target for that
type of
tumor.
The response was not
specific to
tumor type.
Different
types of
tumors show a preference for
specific organs and tissues; circulating breast cancer cells, for example, are likely to take root in bones, lungs, and the brain.
Confirmation of the biomarkers in other cancer
types will facilitate further characterization and validation to provide mechanistic understanding of how and why these
specific gene - targets become modulated to accentuate or inhibit
tumor metastasis.
However, despite this success, the use of immunotherapy remains limited by the scarcity of
tumor -
specific antigens — substances that can trigger an immune system response to a particular
type of cancer.
Baltimore, Md. (Embargoed until 12:30 pm EDT on Monday, June 8)-- A relatively new biomarker called prostate -
specific membrane antigen (PSMA) is the bullseye for three new magnetic resonance imaging (MRI) agents that bind to the protein in not only prostate cancer, but a range of
tumor types, according to research unveiled at the 2015 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI).
The MIT team is now testing this approach to treat
tumors in mice and is also working on ways to deliver the antibodies to
specific types of cells.
«Our results clearly demonstrate a significant, although unexpected, role for
specific gut bacteria in enhancing the immune system's response to melanoma and possibly many other
tumor types,» said study director Thomas Gajewski, MD, PhD, professor of medicine and pathology at the University of Chicago.
Although scientists have examined insulin action in
tumors for years, the ability to knock out the insulin receptor in
specific types of
tumor cells adds a level of sophistication to these investigations, Rask - Madsen emphasizes.
«But we know that
tumors generally develop from a single cell or a small number of cells of a
specific cell
type, which is one of the major determinants of the characteristics of
tumor cells,» explains postdoctoral researcher and co-author Dinorah Friedmann - Morvinski.
So, the researchers forced expression of a dominant - negative TGF - β receptor
type 2 (DNRII) onto LMP -
specific T cells (DNRII - LSTs) that were specially designed to seek out and destroy proteins derived from the Epstein - Barr virus expressed by the
tumor cells.
To get there, researchers will need to resolve certain obstacles associated with CAR - T, including further customization of the technology to recognize
specific / other
tumor types, and predicting and limiting cross-reactivity, where CAR - T immune cells start attacking healthy cells as well.
The median time to response was 1.8 months, and responses occurred regardless of
tumor type, patient age, or
specific TRK fusion characteristics.
Inclusion Criteria: • Availability of
tumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients • Tumor type specific exclusion cri
tumor tissue for mesothelin expression testing • Histologically - confirmed, mesothelin - expressing metastatic or advanced non-metastatic disease (tumour
type specific inclusion criteria) • At least one measurable lesion according to either Response Evaluation Criteria in Solid
Tumors (RECIST) 1.1 or International Thymic Malignancy Interest Group (ITMIG) modified RECIST 1.1 as applicable • Adequate bone marrow, liver, renal and coagulation function • Left ventricular ejection fraction (LVEF) ≥ 50 % of the lower limit of normal (LLN) according to local institutional ranges • Eastern Cooperative Oncology Group (ECOG) 0 or 1 Exclusion Criteria: • More than one prior anti - tubulin / microtubule agent • Corneal epitheliopathy or any eye disorder that may predispose the patients to this condition • Symptomatic Central nervous system (CNS) metastases and / or carcinomatous meningitis • Contraindication to both CT and MRI contrast agents • Active hepatitis B or C infection • Pregnant or breast - feeding patients •
Tumor type specific exclusion cri
Tumor type specific exclusion criteria
Miroslav Machala, head of the Department of Chemistry and Toxicology at the Veterinary Research Institute in the Czech Republic, said in an emailed response that, while these
specific compounds lack data, these
types of PCBs could potentially promote
tumor growth as well.
Biopsy, samples removed from the
tumor and examined to confirm diagnosis of a
specific type of
tumor
The resulting DNA copy number variation and patterns of chromosome loss and gain are
tumor -
type specific, suggesting differential selective pressures on the two
tumor cell
types.
They looked for correlations between
specific mutations in the
tumor cells and the composition of the
tumor microbiome — the
types of bacteria present in the
tumor's immediate environment and their relative abundance — and found relationships between the two.
This confirmed that the gene regulatory switch is highly
specific to one cell
type, monocytes and that
tumor cell invasion in the absence of this population had nothing to do with deregulated macrophage activity.
In fact,
specific mutations in
tumor cells were associated with the presence of
specific types of bacteria in the microbiome.
National Cancer Institute and ECOG - ACRIN announce the July 2015 opening of the NCI - MATCH / EAY131 trial, a multi-arm phase II precision medicine study that seeks to determine whether targeted therapies for people whose
tumors have
specific gene mutations will be effective regardless of cancer
type.
Different
types of
tumors are formed by
specific kinds of microbes.
Cryotherapy which involves freezing the skin
tumors can be successful for
specific types of carcinomas.
The drug represents a new class of treatments that are made to attack a
specific type of
tumor.
The histopathology report will give your veterinarian the diagnosis of the
specific type of
tumor, and that helps to indicate how it is likely to behave.
See below for information on
specific types of cancer such as anal sac and colorectal
tumors.
Information on
specific types of
tumors can be found below.
In rare cases a
tumor called fibrosarcoma may develop at the injection site, however, this has been found to develop in only
specific individuals who are genetically predisposed to form these
tumors secondary to any
type of infection or inflammation.
One of the confusing issues with
tumor submission is that
specific diagnosis of the
tumor type and submitting a sample to the repository are two different submissions.