Sentences with phrase «specific tumors in»

Researchers at Rice University and the University of Texas MD Anderson Cancer Center have refined and, for the first time, run in vivo tests of a method that may allow nanotube - based probes to locate specific tumors in the body.

Rice University and MD Anderson researchers have developed a technique that uses fluorescent nanotube - based probes to locate specific tumors in the body.

Your veterinarian will be able to explain how the specific tumor in your animal is likely to respond to treatment and behave in the future.

Based on the specific diagnostic information that has been obtained for your pet, your veterinarian may be able to predict how the specific tumor in your animal is likely to respond to treatment and behave in the future.

Not exact matches

Furthermore, in cancer patients, the circulating DNA contains the genetic mutations which are specific to the tumor.

«To my great surprise, even injecting 10 million activated T cells specific to the P1A antigen did not affect tumor growth in this induced tumor model,» says Van den Eynde.

In the context of the collaboration between the Gates Center for Stem Cell Biology and the CU Cancer Center this was the second clinical trial we offered to our patients with the specific intent to eliminate the CSCs in their tumors.&raquIn the context of the collaboration between the Gates Center for Stem Cell Biology and the CU Cancer Center this was the second clinical trial we offered to our patients with the specific intent to eliminate the CSCs in their tumors.&raquin their tumors.»

Researchers used tissue and blood samples to show that the gammopathy (a precursor to myeloma) in both mice and patients with Gaucher disease is triggered by specific lipids, and that the antibodies made by tumor cells in nearly a third of myeloma patients are directed against such lipids.

«Shifting bacterial communities in the stomach may influence cancer risk: Microbe changes linked with specific conditions could explain differences in risk and type of tumor.»

«Just as normal cells with the same genome differentiate into many different cell types, a single tumor characterized by specific genetic mutations can contain many different types of cells — stem - like and more differentiated cells — with the difference being rooted in their epigenetic information.

Prostate cancer risk groups are assigned based on the prostate biopsy results, which include the Gleason score (GS)-- an indication of how aggressively the tumor cells may behave — and the prostate specific antigen (PSA) level in the patient's blood at the time of diagnosis.

But in May, the U.S. Food and Drug Administration for the first time allowed the use of an existing approved drug, Keytruda, to treat any solid tumor bearing a specific genetic marker.

«When most people think about cancer genetics, they think about single key mutations that foster tumor formation — very specific things like the BRCA genes,» said Joe R. Delaney, PhD, a fellow in the Clinical Translation program at UC San Diego Moores Cancer Center and lead author of the paper published February 15 in Nature Communications.

Published in the February 27 issue of Cell, the study found that tumor cells that reach the brain — and successfully grow into new tumors — hug capillaries and express specific proteins that overcome the brain's natural defense against metastatic invasion.

«If we could load these virus shells with a different cargo, say a drug, and target it to a particular place in the body, such as a tumor, it could then deliver the drug to just that specific location, making the drug more effective, or reducing side effects,» Lawrence said.

The scientists have shown that, in all cancers, a sort of «identity crisis» is observed in cancerous cells: in the organs or tissues in which a tumor develops, genes specific to other tissues or to other stages of the development of the organism express themselves in an aberrant manner.

Most cancer vaccines developed to date have been designed to recognize and attack a specific known molecule — such as a cell - surface receptor — that is likely to be found on cancerous cells in any patient with that type of tumor.

By focusing on these genes that are «awakened» in tumors, the researchers have shown that in almost all cancers, tens of specific genes in the germline and the placenta are aberrantly activated.

In principle, an attack by such T - cells on tumors should be particularly powerful as well as highly tumor - specific and thus sparing of healthy cells.

The opposing functions of TAMs in the development of tumors arise the question whether there are specific factors within the micro-environment of the tumor which dictate the phenotype of these TAMs.

Scientists now know that what matters most in determining the behavior of a particular cancer (and its response to specific therapy) are the molecular pathways that drive malignant cell growth instead of where the tumor begins in the body.

Indeed, tumors contain a lot of specific macrophages that play a decisive role in the formation of blood vessels.

The new test uses a highly sensitive gene mutation detection method that is based on the partitioning of DNA into droplets to detect specific circulating tumor DNA mutations and RNA variants in whole blood.

A total of 67 biochemical features discriminated cancer from benign tumors in these samples, but only four specific metabolites could be considered as biomarkers for cancer: creatinine riboside, tryptophan, Nε, Nε, Nε - trimethyllysine, and 3 - methylhistidine.

In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spreaIn earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spreain direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.

The title of the paper is «Bioinformatic analysis reveals a pattern of STAT3 - associated gene expression specific to basal - like breast cancers in human tumors.»

In NSCLC there are specific genetic abnormalities within the tumor that can be exploited with drugs specific for the molecular abnormality.

Hoping to cash in on personalized cancer therapy, a new company called Foundation Medicine — founded in part by genome guru Eric Lander of the Broad Institute — plans to develop tests for genetic glitches in tumors that make them vulnerable to specific drugs, reports the United Kingdom's Times Online.

However, it was unclear at this stage in their research if this was a species - specific finding limited to animal tumor models or if this was a biologic phenomenon that may also be present in cancer patients.

«The finding that certain cell signaling lipids change the activity of an oncogenic Ras protein, suggests that we might be able to interfere with tumor progression by inhibiting the enzymes which make the specific cell signaling lipid in cells,» Buck said.

«This study provided a conceptual framework for the discovery of «traceable» targets in cancers harboring specific tumor suppressor deficiencies.»

Approximately 80 percent of DIPG tumors have a specific mutation in a histone gene.

«Identifying targets essential to cell survival in tumor suppressor genes has long been an investigational goal with the aim of offering cancer - specific vulnerabilities for targeted therapy,» said Ronald DePinho, M.D., professor of Cancer Biology, MD Anderson president, and senior author for the Nature paper.

Scientists identified the specific proteins secreted by the parasite Toxoplasma gondii that cause the immune system in mice to attack established ovarian tumors.

«We searched for genes that are occasionally deleted in some cancers but which are retained in cancers caused by specific tumor suppressing genes, such as PTEN,» said Di Zhao, Ph.D., Odyssey postdoctoral fellow in Cancer Biology and first author on the Nature paper.

A new method has been found for identifying therapeutic targets in cancers lacking specific key tumor suppressor genes.

She is investigating the role of glycosylated molecules in tumor progression and metastasis, tissue - and species - specific expression of lectin receptors that play a role in regulating host innate immune responses and inflammation, and the immunological mechanisms underlying chronic inflammation and cancer development.

They found that the levels of two specific tRNAs were significantly higher in metastatic cells and metastatic tumors than in primary tumors that did not metastasize or healthy samples.

A relatively new biomarker called prostate - specific membrane antigen (PSMA) is the bullseye for three new magnetic resonance imaging (MRI) agents that bind to the protein in not only prostate cancer, but a range of tumor types, according to research unveiled at the 2015 annual meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI).

«Knowing the mutations that are driving a tumor over time could help us predict the genetic course of the disease, so that we can intervene in a more specific fashion,» said the studies» senior author Dr. C. Ryan Miller, a member of UNC Lineberger and associate professor in the UNC School of Medicine.

For example, drugs that target a specific BRAF gene mutation commonly found in melanoma shrink tumors in about half of patients with the mutation.

For example, the shells could be functionalized to fluoresce in the presence of specific proteins or to target tumors.

One approach is to give patients specific antibodies that target the homing devices (essentially chemical receptors) in white blood cells, rendering the tumor cells immunologically visible.

Dr. Gnjatic's research focuses on human antigen - specific immune responses to tumor antigens, in an attempt to define new targets for the development of cancer immunotherapies, assess the efficacy of these immunotherapies, and learn why they may fail.

About half of melanoma patients harbor an identical tumor - specific mutation in the BRAF gene, which encodes a protein kinase that helps drive cell growth.

Monje's team identified a specific protein, called neuroligin - 3, which is largely responsible for the increase in tumor growth associated with neuronal activity in the cerebral cortex.

Over the past two years, investigators from the Perelman School of Medicine at the University of Pennsylvania have reported results from a human trial in GBM using chimeric antigen receptor (CAR) T cell therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.

The software allowed them to cluster genes into groups associated with specific molecular processes and see which processes in tumors and blood cells were associated with each other.

Testosterone treatment alone did not induce specific tumors at other sites, but compared with control rats, it caused a significant increase in the number of rats with malignant tumors at any site.

A newly devised tumor - specific fluorescent agent and imaging system guided surgeons in real time to remove additional tumors in ovarian cancer patients that were not visible without fluorescence or could not be felt during surgery, reports Alexander L. Vahrmeijer MD, PhD, head of the Image - guided Surgery group in the Department of Surgery at Leiden University Medical Center in the Netherlands.