Sentences with phrase «specific type of mutation»

This study will test the hypothesis that much of the morphological variation between individuals is due to a specific type of mutation that involves repeated sequences in genes.

PKU is caused by a mutation that is located on chromosome 12, although the specific type of mutation may vary, which results in severity that is variable among those with the PKU disorder.

Not exact matches

In recent years, scientists have devised drugs to target specific mutations in one type of cancer.

«Just as normal cells with the same genome differentiate into many different cell types, a single tumor characterized by specific genetic mutations can contain many different types of cells — stem - like and more differentiated cells — with the difference being rooted in their epigenetic information.

Instead they search specific regions of the genome for a type of mutation known as a single nucleotide polymorphism, or SNP (pronounced «snip»).

The two - part approach netted a set of mutations seen only at relapse that enabled the team to sift and sort leukemic and normal stem cells using tools developed in the Dick lab a few years ago to zero in on specific cell types fated to relapse.

The researchers studied a form of the condition called Charcot - Marie - Tooth disease type 2A, which is caused by specific genetic mutations.

Though a range of developmental scenarios in multiple brain regions is surely at work in ASDs, the researchers said the ability to place these specific genetic mutations in one specific set of cells — among hundreds of cell types in the brain, and at a specific point in human development — is a critical step in beginning to understand how autism comes about.

Another research goal is to find out whether the mutation leads to specific types of tumours or cancers that are triggered at a particular time of life.

The researchers predicted that the TRPC5 mechanism might play a similar role in other types of progressive kidney disease — even if, in those cases, the damaging feedback loop was kickstarted from chronic disorders such as high blood pressure, rather than a specific genetic mutation.

Other environments do not have increased total mutations but we find that the proportions of 16 different types of mutation are all environment - specific.

Such similar global, spermatogenic - specific impacts of mutations in orthologs in divergent phyla is surprising and unprecedented, given the vastly different organization of testicular structure, type of spermatogenesis and differences in the contribution of hormonal control in mammals and insects.

They looked for correlations between specific mutations in the tumor cells and the composition of the tumor microbiome — the types of bacteria present in the tumor's immediate environment and their relative abundance — and found relationships between the two.

To study their role in such disorders, we generated knock - in mice with hematopoietic - specific expression of Sf3b1 - K700E, the commonest type of SF3B1 mutation in MDS.

There are two general types of resistance genes found in wheat: Race - specific genes confer a high - level of resistance to specific strains of leaf rust but can be easily overcome by genetic mutation in pathogen populations, while slow rusting (APR) resistance provides partial resistance to a broad spectrum of races, but is typically effective only at the adult stage of plant growth.

In fact, specific mutations in tumor cells were associated with the presence of specific types of bacteria in the microbiome.

Our researchers have made key discoveries of the specific gene mutations and proteins involved in both syndromic and non-syndromic congenital sideroblastic anemias, and we have an open research protocol that is helping us to reach our ultimate goal of understanding the genetic basis of all types of CSAs.

This provided the mechanism by which bacteria acquire immunity to specific viral infections, allowed introduction of specific mutations at desired sites, and provided the means to transfer efficient Cas9 - directed break, repair, and editing to any cell type.

The Cancer Gene Census (CGC) database contains 547 such gene across various cancer types.5 Remarkably, few driver genes having specific point mutations appear to be sufficient to rewire signalling networks in cancer, 1 which at the same time shows that — at least from the mutational side — cancer does not consist of an «infinite» number of different diseases, and in many cases treatment options targeted against driver genes might be transferred from one case to the next.

National Cancer Institute and ECOG - ACRIN announce the July 2015 opening of the NCI - MATCH / EAY131 trial, a multi-arm phase II precision medicine study that seeks to determine whether targeted therapies for people whose tumors have specific gene mutations will be effective regardless of cancer type.

The reason for all the types of mutations is variations in the specific genes passed on from each parent.

A specific type of Memetic Mutation, like the Memetic Badass but far, far worse for the character's...

A specific type of Memetic Mutation, like the Memetic Badass but far, far worse for the character's... Anal Sakura Instructions: Haruno Sakura loses a fight againt a fire creature, and has to give up her ass virginity.

The scientists are also continuing to investigate mutations that occur in the tumors themselves (somatic mutations) and are profiling the susceptibility of specific tumor types to various chemotherapy compounds, which may lead to improved therapy options.

While it is not yet known what causes the mutations to occur, research has suggested that a hormone imbalance involving testosterone may play a role in this specific type of cancer.