Sentences with phrase «specific ubiquitin»

Not exact matches

The new research has found that this attachment of ubiquitin by BRCA1, its «ubiquitin ligase activity», is needed for a specific type of DNA repair that is «error - free», known as homologous recombination.

He predicts that the discovery will help researchers develop very specific anti-inflammatory drugs that can subtly tweak the body's immune responses by targeting distinct ubiquitin ligases and similar enzymes involved in cellular garbage disposal.

If — as in the eukaryotic ubiquitin - based system — the access to the protease depends on a specific tag that must be carried by the substrate, then the important decision who and when should be eliminated boils down to the timely and selective attachment of tags.

In humans, there are about 100 proteins associated with ubiquitination, the process by which a protein labelled with ubiquitin is removed from the cell by specific cell machinery known as the proteosome.

One enzyme in particular, BRCC36, removes a specific type of ubiquitin that is central to DNA damage repair as well as inflammatory responses.

Most importantly, though, we can manipulate individual residues of ubiquitin to force specific chains to form in the cell.»

Although some approved cancer drugs and others in development interfere with the same protein cleanup process, known as the ubiquitin - proteasome system, disulfiram targets only a specific molecular complex within this machinery.

After induction of interferon - stimulated genes (ISGs), the ubiquitin - specific protease USP18 docks to the receptor complex via STAT2, thus interfering with receptor dimerization and STAT phosphorylation.

Control of virus - specific CD8 + T - cell exhaustion and immune - mediated pathology by E3 ubiquitin ligase Cbl - b during chronic viral infection.

For example, whereas the p53 / p63 / p73 tumour suppressor family is holozoan - specific31, the HIPK kinase that phosphorylates p53 in the presence of DNA breaks is metazoan - specific, and the MDM2 ubiquitin ligase that regulates p53 appears as a eumetazoan feature.

Ubiquitination of Oct4 by a specific E3 ubiquitin ligase, with resultant proteasomal degradation, has previously been described [24].

«Skeletal muscle from animals randomized to PMI 5011 was demonstrated to have decreased 20S proteasome activity and reduced gene expression of specific proteins as part of the ubiquitin — proteasome system in skeletal muscle», they write.

This second set of experiments in cultured muscle cells showed that HMB attenuated a specific pathway involving caspase 3 and 8, PKR (RNA dependent protein kinase), and reactive oxygen species (ROS) known to activate the ubiquitin - protease pathway.