Another possibility that Irvine's lab is working on is developing treatments that could be used against tumors even when scientists don't know of
a specific vaccine target for that type of tumor.
Not exact matches
The results from the study could be used to help public health officials to plan a more effective response to future pandemics, such as rolling out
vaccines at a much earlier time and
targeting specific types of
vaccines at different age groups.
Unlike most other bioterror agents, H5N1 can be fought with
vaccines and drugs, and can not be
targeted to a
specific population.
To develop subunit
vaccines for other diseases, scientists have tried
targeting them to lymph nodes using nanoparticles to deliver them, or tagging them with antibodies
specific to immune cells in the lymph nodes.
Future candidate
vaccines are therefore likely to include this glycan cluster among their
specific viral
targets in order to maximize the chances of stimulating an effective antibody response.
They think that the old
vaccine could be useful for
specific target groups, such as the elderly.
Whereas earlier, unsuccessful cancer
vaccines usually
targeted a single distinctive cancer protein shared among patients, these new ones contain multiple mutated proteins, or «neoantigens,» that are
specific to an individual patient's tumor.
Most importantly, many of the T cells were able to recognize the tumor cells directly, demonstrating that the
vaccine had triggered a tumor -
specific immune response that could
target the patient's tumor.
A study led by St. Jude Children's Research Hospital identifies new path to a universal influenza
vaccine emphasizing production of broadly
specific antibodies that
target multiple flu viruses
A personal cancer treatment
vaccine that
targets distinctive «neoantigens» on tumor cells has been shown to stimulate a potent, safe, and highly
specific immune anti-tumor response in melanoma patients, report scientists from Dana - Farber Cancer Institute and the Broad Institute of MIT and Harvard.
These technologies are particularly powerful when looking for changes in concentrations of multiple
targets under
specific conditions, such as following a
vaccine administration, infection, or a drug treatment.
Being both tumor -
specific and widely expressed in human tumors, MAGE - A3 is an ideal cancer
vaccine target and will be the focus of many clinical trials, including the largest clinical trial ever conducted in lung cancer, MAGRIT, launched by GlaxoSmithKline in 2007.
Researchers are studying how to use tumour -
specific neoantigens in
vaccines to help the body mount an immune response
targeted at the cancer.
«Each patient is different, so we're developing a personalized
vaccine based on
specific targets we identify on a patient's tumor,» Overman says.
Bhardwaj, a CRI Clip Investigator and Clinical Team Leader who is also involved in CRI's Tumor neoantigEn SeLection Alliance (TESLA), first discussed the computational pipeline that her team is using to identify patient -
specific neoantigens to
target via
vaccines.
At first, analyzing a patient's surgically removed tumor and developing a
vaccine against 10
specific targets on the tumor took nine months, says Greg Lizée, Ph.D., associate professor of Melanoma Medical Oncology, whose research focuses on the immune system.
These are more
specific therapies such as monoclonal antibodies and cancer
vaccines, which
target specific tumor antigens.
Using gene -
targeted mice and human cells that lack
specific components of the immune system, a better understanding of the immune response to DENV and ZIKV is critical for developing much - needed
vaccines and antivirals.
Provenge and other therapeutic
vaccines involve personalized therapy that
targets the patient's
specific tumor.