The experiments have shown that the inhibition of endosomal acidification prevents the activation of P45 - IKKα and
specifically inhibits the growth of cancer cells with mutant BRAF, both in vitro and in vivo.
Not exact matches
Specifically, my research proposal addresses the mechanisms by which the kinase 3 - phosphoinoside dependent protein kinase - 1 (PDK1) mediates resistance to
cell cycle related CDK4 / 6 inhibition in ER + breast
cancer and explores the in vivo effects
of inhibiting PDK1 in combination with CDK4 / 6 inhibitors toward ER + breast
cancer growth.
that
specifically inhibit tumor
growth by targeting the Hedgehog pathway have been approved by the FDA to treat basal
cell carcinoma, giving patients with advanced cases
of this type
of skin
cancer a better chance
of survival.
Since 2012, two drugs that
specifically inhibit tumor
growth by targeting the Hedgehog pathway have been approved by the FDA to treat basal
cell carcinoma, giving patients with advanced cases
of this type
of skin
cancer a better chance
of survival.