Sentences with phrase «specificity phosphatase»

Furthermore, one locus near dual specificity phosphatase 9 on the X chromosome is directly associated with higher T2DM risk (192).

PTEN, encoding a dual specificity phosphatase on 10q23.3, is being examined in Cowden and other hamartoma syndromes and isolated cancers.

Patterson, K. I., Brummer, T., O'Brien, P. M. & Daly, R. J. Dual - specificity phosphatases: critical regulators with diverse cellular targets.

Not exact matches

Recent studies such as ours, however, establish protein phosphatases as positive and essential regulators of signal transduction, with remarkable substrate specificity and coordinated activities.

The protein phosphatases were too long thought to just be the negative counterpart of protein kinases, with promiscuous activity and low intrinsic substrate specificity.

There have been a number of challenges with these new drugs, and they haven't really made it to phase three clinical trials, and so the reason is that it's very difficult to develop very specific inhibitors, because there is a large family of these phosphatases and it's difficult to ensure a specificity of your drug.