The amount
of sphingomyelin changes over time, and is largely dependent on your diet.
This project will examine the signalling pathways that link phenotypic modulation to exosome secretion focussing on the cytoskeleton, extracellular matrix (ECM) as well
as sphingomyelin / ceramide pathway mediators.
The following tidbit will give you an idea of how these nutrients come into play: by analyzing the composition of veins, Dr. Kummerow showed that people undergoing a heart bypass typically have 40 to 60 percent of something
called sphingomyelin in their arteries.
«When half the artery was
now sphingomyelin, the salt in the blood causes it to have a negative charge; the calcium in the arteries has a positive charge.
CerDase, ceramidase; CerS, ceramide synthase; GalCeramidase, galactosylceramidase; GalCer sulfotransferase, galactosyl sulfotransferase; Gal - T1, galactosyltransferase; GluCeramidase, glucosylceramidase; GluCer synthase, glucosylceramide synthase; Sial - T1, lactosylceramide synthase; SM synthase,
sphingomyelin synthase; SMase, sphingomyelinase.
Schematic diagram of transient binding
of sphingomyelin to various forms of CD59, which was clarified in this study.
Emerging science findings indicate that milk fat contains several components such as conjugated linoleic acid (CLA),
sphingomyelin, butyric acid and myristic acid, which may potentially protect against major chronic disease.
This segregation is achieved in a number of ways, including the formation of domains based on particular lipids such as cholesterol or
sphingomyelin (SM).
Bottom: Schematic model showing the transient recruitment of
sphingomyelins to various raft domains in the time scale of 10 to 50 milliseconds.
The sphingomyelin analog molecule was associated with a signaling raft domain from frame 4 to 9 (orange arrows).
Top: Typical image sequences (every 33 milliseconds) of a raft domain undergoing signaling (green) and
a sphingomyelin analog (red).
(Figure 3) Schematic diagram of transient binding of
sphingomyelin to various forms of CD59, which was clarified in this study.
Oxidized fats promote the creation of
sphingomyelin.