Sentences with phrase «sphingosine kinase»

Resveratrol is also known to inhibit numerous pro-inflammatory actors, messengers and chemicals, including sphingosine kinase, COX - 2, NF - KappaB and phospholipase D (which is great news for acne).

Sphingosine kinase 2 (SK2) is an enzyme that synthesizes a fat - like molecule that regulates a variety of cellular properties.

The phospholipid is generated when sphingosine kinase 1, called SK1 for short, translocates to the plasma membrane and phosphorylates sphingosine, but the membrane recruitment step is not well - understood.

We further discovered that this bile acid signaling through S1PR2 and Sphingosine kinase 2 regulate lipid metabolism in hepatocytes (Nagahashi M et al, Hepatology 2015), thus play a role in development of Non-Alcoholic Fatty Liver Disease (Hylemon P et al, Hepatology 2016).

Nagahashi M, Takabe K, Liu R, Wang Y, Hait NC, Wang X, Allegood JC, Yamada A, Aoyagi T, Liang J, Pandak WM, Cooper P, Spiegel S, Hylemon PB, and Zhou H. Conjugated Bile Acid Activated S1P Receptor 2 Is a Key Regulator of Sphingosine Kinase 2 and Hepatic Gene Expression.

Intracellularly, we found that LPA1 upregulate sphingosine kinase 1 (Shida D et al, Cancer Research 2008) via ERK1 - dependent manner (Ramachandran S et al, FEBS Letter 2010), and S1P play an essential role in IL - 1 induced CXCL10 and CCL5 production (Harikumar KB et al, Nature Immunology 2014).

Sphingosine kinase 1 protects against renal ischemia — reperfusion injury in mice by sphingosine -1-phosphate1 receptor activation.

Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking.

They found that sickle cell disease significantly increases S1P and that S1P is generated by sphingosine kinase 1 (SphK1).

S1P is a signaling lipid mediator, which is generated inside the cells by sphingosine kinases, exported out of the cells, then bind and signal through five S1P specific G - protein coupled receptors (S1PR1 - 5), coined «inside - out signaling» (Takabe K et al, Pharmacological Reviews 2008, Takabe K et al, Journal of Lipid Research 2014).

Not exact matches

Astonishingly, sphingosine -1-phosphate is only released in the macrophages if — alongside with the binding of dimer - GR to the DNA — a pro-inflammatory signalling pathway is stimulated involving protein kinases p38 and MSK1.