Sentences with phrase «splice forms»
"Splice forms" refers to different versions or variations of a specific gene or protein that are created through a process called splicing. Splicing involves rearranging the building blocks of genetic information to create different forms with slightly different functions or properties. Full definition
The DGCr3 currently includes clones chosen to replace clones with truncated ORFs, clones for genes that are not currently represented in the DGC, plus clones that represent putative alternative splicing forms.
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The study demonstrates the importance of using complementary digestion schemes in research where identifying different splice forms of proteins is a priority.
In myotonic dystrophic patients, titration of MBNL protein by RNA containing expanded CUG repeats leads to expression of a fetal splicing form of the cardiac sodium channel, SCN5A, inappropriate to adult heart physiology, ultimately resulting in cardiac conduction delay and heart arrhythmias, which are two key features of myotonic dystrophy.
Alternative splicing has been shown to occur in up to 94 percent of human genes, resulting in expression of different splice forms for each gene.
It is estimated that of the approximately 25,000 genes in the human genome, approximately 90 % have alternative splice forms.
This gene was confirmed as the Nasonia ortholog of doublesex based on protein domains, expression pattern, sex specific splice forms, and experimental demonstration that splice forms are associated with sex in a gynandromorph producing line [18].